Natalia Koerich Laureano
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View article: Editorial: Early diagnosis in head and neck cancer: advances, techniques, and challenges
Editorial: Early diagnosis in head and neck cancer: advances, techniques, and challenges Open
View article: Bone quality assessment around dental implants in cone-beam CT images: effect of rotation mode and metal artefact reduction tool
Bone quality assessment around dental implants in cone-beam CT images: effect of rotation mode and metal artefact reduction tool Open
Objectives The purpose of this study was to evaluate how artefacts caused by titanium and zirconia dental implants affect the bone quality assessment in CBCT images. The effect of scan mode and the use of metal artefact reduction (MAR) alg…
View article: The Role of SOX2 and SOX9 in Radioresistance and Tumor Recurrence
The Role of SOX2 and SOX9 in Radioresistance and Tumor Recurrence Open
Head and neck squamous cell carcinoma (HNSCC) exhibits considerable variability in patient outcome. It has been reported that SOX2 plays a role in proliferation, tumor growth, drug resistance, and metastasis in a variety of cancer types. A…
View article: Temporal epidemiological profile of oral potentially malignant disorders in southern Brazil
Temporal epidemiological profile of oral potentially malignant disorders in southern Brazil Open
The study aimed to investigate oral potentially malignant disorders (OPMDs) diagnosed in an Oral Pathology service in southern Brazil over a span of 56 years and to assess the factors influencing their severity and outcomes. A retrospectiv…
View article: Chemoprevention in oral leukoplakia: challenges and current landscape
Chemoprevention in oral leukoplakia: challenges and current landscape Open
Oral potentially malignant disorders have the potential to transform into oral cancer. Oral leukoplakia is a prevalent OPMD with a 9.8% malignant transformation rate. The standard management for OL involves surgical excision, but its effic…
View article: Heat Shock Protein Family a (Hsp70) Member 5 (HSPA5) Levels Increases in Head and Neck Carcinogenesis and its Modulation by Docosahexaenoic Acid Can Delay Cancer Development
Heat Shock Protein Family a (Hsp70) Member 5 (HSPA5) Levels Increases in Head and Neck Carcinogenesis and its Modulation by Docosahexaenoic Acid Can Delay Cancer Development Open
View article: Organotypic Co-Cultures as a Novel 3D Model for Head and Neck Squamous Cell Carcinoma
Organotypic Co-Cultures as a Novel 3D Model for Head and Neck Squamous Cell Carcinoma Open
Background: Head and neck squamous cell carcinomas (HNSCC) are phenotypically and molecularly heterogeneous and frequently develop therapy resistance. Reliable patient-derived 3D tumor models are urgently needed to further study the comple…
View article: Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer
Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer Open
Genomic sequencing projects unraveled the mutational landscape of head and neck squamous cell carcinoma (HNSCC) and provided a comprehensive catalog of somatic mutations. However, the limited number of significant cancer‐related genes obta…
View article: Tumor cell plasticity in the pathogenesis and prognosis of head and neck cancer
Tumor cell plasticity in the pathogenesis and prognosis of head and neck cancer Open
Experimental and clinical studies support a model in which a distinct subpopulation of invasive and therapy resistant cancer cells drives treatment failure in head and neck cancer (HNC). Common features of this subpopulation are a high deg…
View article: Plastizität von Tumorzellen bei der Pathogenese und Prognose von Kopf- und Halstumoren
Plastizität von Tumorzellen bei der Pathogenese und Prognose von Kopf- und Halstumoren Open
Experimentelle und klinische Studien belegen ein Modell, in dem eine Subpopulation von invasiven und resistenten Tumorzellen für das Therapieversagen bei Kopf- und Halstumoren (HNC) verantwortlich ist. Eigenschaften dieser Tumorzellen sind…
View article: Low SOX2 expression marks a distinct subset of adenoid cystic carcinoma of the head and neck and is associated with an advanced tumor stage
Low SOX2 expression marks a distinct subset of adenoid cystic carcinoma of the head and neck and is associated with an advanced tumor stage Open
The absence of SOX2 was predominantly found in solid HNACC, which are characterized by a more aggressive phenotype in ACC. However, the underlying molecular mechanisms of SOX2 regulation and function in distinct HNACC subgroups remain to b…
View article: Cell proliferation markers at the invasive tumor front of oral squamous cell carcinoma: comparative analysis in relation to clinicopathological parameters of patients
Cell proliferation markers at the invasive tumor front of oral squamous cell carcinoma: comparative analysis in relation to clinicopathological parameters of patients Open
Our results suggest that proliferation markers as AgNOR and Ki-67 are not prognostic markers at the tumor invasive front of carcinoma of oral squamous cell.
View article: Expression of E-cadherin and involucrin in leukoplakia and oral cancer: an immunocytochemical and immunohistochemical study
Expression of E-cadherin and involucrin in leukoplakia and oral cancer: an immunocytochemical and immunohistochemical study Open
To assess the immunocytochemical and immunohistochemical correlation of adhesion (E-cadherin) and cell differentiation (involucrin) molecules in oral leukoplakia and oral squamous cell carcinoma. Cytological samples and biopsies were obtai…
View article: Estudo da variação da velocidade de proliferação das células da mucosa bucal : acompanhamento de 24 meses
Estudo da variação da velocidade de proliferação das células da mucosa bucal : acompanhamento de 24 meses Open
View article: Estudo do efeito do tabagismo e seu abandono sobre a velocidade de proliferação das células da mucosa bucal : avaliação longitudinal
Estudo do efeito do tabagismo e seu abandono sobre a velocidade de proliferação das células da mucosa bucal : avaliação longitudinal Open
OBJETIVO: avaliar através da citopatologia, associada a técnica AgNOR, o reflexo da cessação do fumo sobre a velocidade de proliferação das células epiteliais descamadas de borda de língua (BL) e assoalho de boca (AB), ao longo do tempo. M…