Natalia Koralewska
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View article: The Network of National COVID-19 Data Portals: public health equity through collaboration
The Network of National COVID-19 Data Portals: public health equity through collaboration Open
The network of the national COVID-19 Data Portals was developed and linked to the COVID-19 Data Portal (https://www.covid19dataportal.org/) in response to the need for rapid data sharing and analysis during the 2020-2022 SARS-CoV-2 pandemi…
View article: The landscape of the COVID-19 pandemic in Poland emerging from epidemiological and genomic data
The landscape of the COVID-19 pandemic in Poland emerging from epidemiological and genomic data Open
The COVID-19 pandemic has profoundly affected all aspects of our lives. Through real-time monitoring and rapid vaccine implementation, we succeeded in suppressing the spread of the disease and mitigating its consequences. Finally, conclusi…
View article: Short 2′-<i>O</i>-methyl/LNA oligomers as highly-selective inhibitors of miRNA production <i>in vitro</i> and <i>in vivo</i>
Short 2′-<i>O</i>-methyl/LNA oligomers as highly-selective inhibitors of miRNA production <i>in vitro</i> and <i>in vivo</i> Open
MicroRNAs (miRNAs) that share identical or near-identical sequences constitute miRNA families and are predicted to act redundantly. Yet recent evidence suggests that members of the same miRNA family with high sequence similarity might have…
View article: A survey into the contribution of regional/national pathogen data platforms and on the resources needed to develop and maintain them
A survey into the contribution of regional/national pathogen data platforms and on the resources needed to develop and maintain them Open
Background Regional/national SARS-CoV-2 genomic data platforms (DP) have played a key role during the Covid-19 pandemic to centralize data, curate, process and re-share them in a consistent form and pseudonymized/anonymized to internationa…
View article: Short 2′-O-methyl/LNA oligomers as highly-selective inhibitors of miRNA production<i>in vitro</i>and<i>in vivo</i>
Short 2′-O-methyl/LNA oligomers as highly-selective inhibitors of miRNA production<i>in vitro</i>and<i>in vivo</i> Open
MicroRNAs (miRNAs) that share identical or near-identical sequences constitute miRNA families and are predicted to act redundantly. Yet recent evidence suggests that members of the same miRNA family with high sequence similarity might have…
View article: Pacjent post-COVID-owy Co już wiemy, a co przed nami? / A post-COVID patient What we know and what is ahead of us?
Pacjent post-COVID-owy Co już wiemy, a co przed nami? / A post-COVID patient What we know and what is ahead of us? Open
Pacjent post-COVID-owy Co już wiemy, a co przed nami? II Konferencja naukowa Warszawa/online 14–15 listopada 2022 A post-COVID patient What we know and what is ahead of us? 2nd Research Conference Warsaw/…
View article: RNA and DNA G-quadruplexes bind to human dicer and inhibit its activity
RNA and DNA G-quadruplexes bind to human dicer and inhibit its activity Open
View article: RNA and DNA G-quadruplexes bind to human Dicer and inhibit its activity
RNA and DNA G-quadruplexes bind to human Dicer and inhibit its activity Open
Guanine (G)-rich single-stranded nucleic acids can adopt G-quadruplex structures. Accumulating evidence indicates that G-quadruplexes serve important regulatory roles in fundamental biological processes such as DNA replication, transcripti…
View article: RNA and DNA G-quadruplexes bind to human Dicer and inhibit its activity;
RNA and DNA G-quadruplexes bind to human Dicer and inhibit its activity; Open
Guanine (G)-rich single-stranded nucleic acids can adopt G-quadruplex structures. Accumulating evidence indicates that G-quadruplexes serve important regulatory roles in fundamental biological processes such as DNA replication, transcripti…
View article: Ludzka rybonukleaza Dicer – struktura i funkcje biologiczne
Ludzka rybonukleaza Dicer – struktura i funkcje biologiczne Open
Rybonukleaza Dicer jest znana przede wszystkim z kluczowej roli, jaką odgrywa w procesie biogenezy krótkich regulatorowych RNA: miRNA oraz siRNA. Badania prowadzone w ostatnich latach znacząco wzbogaciły wiedzę dotyczącą funkcji pełnionyc…
View article: How short RNAs impact the human ribonuclease Dicer activity: putative regulatory feedback-loops and other RNA-mediated mechanisms controlling microRNA processing
How short RNAs impact the human ribonuclease Dicer activity: putative regulatory feedback-loops and other RNA-mediated mechanisms controlling microRNA processing Open
Ribonuclease Dicer plays a pivotal role in RNA interference pathways by processing long double-stranded RNAs and single-stranded hairpin RNA precursors into small interfering RNAs (siRNAs) and microRNAs (miRNAs), respectively. While detail…
View article: Revealing a new activity of the human Dicer DUF283 domain in vitro
Revealing a new activity of the human Dicer DUF283 domain in vitro Open
The ribonuclease Dicer is a multidomain enzyme that plays a fundamental role in the biogenesis of small regulatory RNAs (srRNAs), which control gene expression by targeting complementary transcripts and inducing their cleavage or repressin…
View article: Six Medicago truncatula Dicer-like protein genes are expressed in plant cells and upregulated in nodules
Six Medicago truncatula Dicer-like protein genes are expressed in plant cells and upregulated in nodules Open
View article: RNA oligomers as microRNA production process regulators
RNA oligomers as microRNA production process regulators Open
The present invention relates to an RNA oligomer, methods for regulating’a microRNA (miRNA) production process and RNA oligomers used as miRNA production process regulators. More precisely, the present invention relates to use of RNA oligo…
View article: The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities
The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities Open
There is increasing evidence indicating that the production of small regulatory RNAs is not the only process in which ribonuclease Dicer can participate. For example, it has been demonstrated that this enzyme is also involved in chromatin …