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View article: High-Intensity Focused Ultrasound in Dermatology: A Review with Emphasis on Skin Cancer Management and Prevention
High-Intensity Focused Ultrasound in Dermatology: A Review with Emphasis on Skin Cancer Management and Prevention Open
High-intensity focused ultrasound (HIFU) has recently emerged as a novel non-invasive treatment modality in dermatology, offering precise ablation of cutaneous lesions with minimal damage to surrounding tissue. Originally developed for dee…
View article: High-Intensity Focused Ultrasound (HIFU) Treatment of Vulvar Lichen Sclerosus
High-Intensity Focused Ultrasound (HIFU) Treatment of Vulvar Lichen Sclerosus Open
Vulvar lichen sclerosus (VLS) is a chronic, recurrent dermatosis predominantly affecting postmenopausal women. It is characterized by atrophic and sclerotic changes in the vulvar skin, often causing severe discomfort and functional impairm…
View article: Treatment of Sebaceous Hyperplasia by High-Frequency Focused Ultrasound (HIFU): A Comprehensive Exploration with Clinical Insights
Treatment of Sebaceous Hyperplasia by High-Frequency Focused Ultrasound (HIFU): A Comprehensive Exploration with Clinical Insights Open
Background: Sebaceous hyperplasia (SH) is a common benign condition characterized by enlarged sebaceous glands, often requiring treatment for cosmetic or symptomatic reasons. Conventional therapies include laser ablation, electrosurgery, a…
View article: The Influence of Environmental Exposure to Xenoestrogens on the Risk of Cancer Development
The Influence of Environmental Exposure to Xenoestrogens on the Risk of Cancer Development Open
Xenoestrogens (XEs) are a group of exogenous substances that may interfere with the functioning of the endocrine system. They may mimic the function of estrogens, and their sources are plants, water or dust, plastic, chemical agents, and s…
View article: Avelumab reduces STAT3 expression with effects on IL-17RA and CD15
Avelumab reduces STAT3 expression with effects on IL-17RA and CD15 Open
Our study suggests that the targeting of PD-L1 with avelumab alters the expression of CD15 and IL-17RA, which play an important prognostic and therapeutic role in novel anticancer therapy.
View article: Correlating dermatoscopic features with immunohistochemical markers in basal cell carcinoma: a comprehensive analysis of 100 cases in Caucasian population
Correlating dermatoscopic features with immunohistochemical markers in basal cell carcinoma: a comprehensive analysis of 100 cases in Caucasian population Open
Background Basal Cell Carcinoma (BCC) is the most common form of skin cancer, characterized by its low metastatic potential yet considerable diversity in clinical and dermatoscopic presentation. Advances in dermatoscopy have significantly …
View article: Case report: Sequential treatment strategy for advanced basal cell carcinoma in Gorlin-Goltz syndrome: integration of vismodegib, radiotherapy, surgery, and high-intensity focused ultrasound
Case report: Sequential treatment strategy for advanced basal cell carcinoma in Gorlin-Goltz syndrome: integration of vismodegib, radiotherapy, surgery, and high-intensity focused ultrasound Open
Managing advanced basal cell carcinoma (BCC) in patients with Gorlin-Goltz syndrome presents unique clinical challenges due to the tumor’s aggressive nature and potential for widespread metastasis. This case study details a sequential trea…
View article: Novel Approach: Diphenhydramine and Lidocaine Combination Therapy for Alleviating Inflammatory and Allergic Skin Conditions with Coexisting Itch
Novel Approach: Diphenhydramine and Lidocaine Combination Therapy for Alleviating Inflammatory and Allergic Skin Conditions with Coexisting Itch Open
Skin inflammatory and allergic conditions often result in symptoms such as erythema, edema, and pruritus, significantly impacting patients' quality of life. Traditional treatment approaches target either the inflammatory or allergic compon…
View article: Pilot Study on High-Intensity Focused Ultrasound (HIFU) for Basal Cell Carcinoma: Effectiveness and Safety
Pilot Study on High-Intensity Focused Ultrasound (HIFU) for Basal Cell Carcinoma: Effectiveness and Safety Open
Background: The rising incidence of Basal Cell Carcinoma (BCC), especially among individuals with significant sun exposure, underscores the need for effective and minimally invasive treatment alternatives. Traditional surgical approaches, …
View article: Pulsed electric field induces exocytosis and overexpression of MAGE antigens in melanoma
Pulsed electric field induces exocytosis and overexpression of MAGE antigens in melanoma Open
Nanosecond pulsed electric field (nsPEF) has emerged as a promising approach for inducing cell death in melanoma, either as a standalone treatment or in combination with chemotherapeutics. However, to date, there has been a shortage of stu…
View article: High Intensity Focused Ultrasound (20 MHz) and Cryotherapy as Therapeutic Options for Granuloma Annulare and Other Inflammatory Skin Conditions
High Intensity Focused Ultrasound (20 MHz) and Cryotherapy as Therapeutic Options for Granuloma Annulare and Other Inflammatory Skin Conditions Open
Hyperthermic immunological activation of 20 MHz HIFU shows promise for treating inflammatory skin conditions as exemplified by GA. Numerical models demonstrate minimal skin necrosis compared to cryotherapy. Suggested optimal HIFU parameter…
View article: Impact of Bisphosphonate Therapy on Oral Health in Patients with Breast and Prostate Cancer and Bone Metastases: A Comprehensive Study
Impact of Bisphosphonate Therapy on Oral Health in Patients with Breast and Prostate Cancer and Bone Metastases: A Comprehensive Study Open
This study investigates the impact of bisphosphonate therapy on the stomatognathic system in 80 patients with cancer of the breast and prostate with bone metastases. Bisphosphonates are integral for managing skeletal complications in these…
View article: Healing Process after High-Intensity Focused Ultrasound Treatment of Benign Skin Lesions: Dermoscopic Analysis and Treatment Guidelines
Healing Process after High-Intensity Focused Ultrasound Treatment of Benign Skin Lesions: Dermoscopic Analysis and Treatment Guidelines Open
Background: High-Intensity Focused Ultrasound (HIFU) has emerged as a precise and non-invasive modality for tissue ablation and healing. This study presents a detailed dermoscopic analysis of skin healing post-High-Intensity Focused Ultras…
View article: Case report: Exceptional disease progression in a 70-year-old patient: generalized melanosis and melanuria in the course of metastatic melanoma - a case study
Case report: Exceptional disease progression in a 70-year-old patient: generalized melanosis and melanuria in the course of metastatic melanoma - a case study Open
This case study documents an extraordinary disease progression in a 70-year-old patient diagnosed with metastatic melanoma. The patient’s condition advanced to an unusual manifestation characterized by generalized melanosis and melanuria, …
View article: Assessing Excessive Keratinization in Acral Areas through Dermatoscopy with Cross-Polarization and Parallel-Polarization: A Dermatoscopic Keratinization Scale
Assessing Excessive Keratinization in Acral Areas through Dermatoscopy with Cross-Polarization and Parallel-Polarization: A Dermatoscopic Keratinization Scale Open
Excessive epidermal hyperkeratosis in acral areas is a common occurrence in dermatology practice, with a notable prevalence of approximately 65% in the elderly, especially in plantar lesions. Hyperkeratosis, characterized by thickening of …
View article: Effects of Nanosecond Pulsed Electric Field on Immune Checkpoint Receptors in Melanoma Cells
Effects of Nanosecond Pulsed Electric Field on Immune Checkpoint Receptors in Melanoma Cells Open
Checkpoint molecules such as PD-1, LAG-3, and TIM-3 are currently under extensive investigation for their roles in the attenuation of the immune response in cancer. Various methods have been applied to overcome the challenges in this field…
View article: Prognostic Role of Prolactin-Induced Protein (PIP) in Breast Cancer
Prognostic Role of Prolactin-Induced Protein (PIP) in Breast Cancer Open
Prolactin-inducible protein (PIP), also referred to as gross cystic disease fluid protein 15 (GCDFP-15), has been a trending topic in recent years due to its potential role as a specific marker in breast cancer. PIP binds to aquaporin-5 (A…
View article: Over the Counter Pain Medications Used by Adults: A Need for Pharmacist Intervention
Over the Counter Pain Medications Used by Adults: A Need for Pharmacist Intervention Open
Background: The safety of pharmacotherapy for geriatric patients is an essential aspect of the demographic perspective in view of the increasing size of this population. Non-opioid analgesics (NOAs) are among the most popular and often ove…
View article: In vitro dissolution test of ketoprofene: development and evaluation of release from soft and hard gelatine capsules
In vitro dissolution test of ketoprofene: development and evaluation of release from soft and hard gelatine capsules Open
Ketoprofen belongs to a group of widely used non-steroidal anti-inflammatory drugs (NSAIDs). It is found in several doses and various forms of medications. Therapeutic efficacy is related to the rate of release of the active substances, wh…
View article: Nanosecond Pulsed Electric Field Suppresses Growth and Reduces Multi-drug Resistance Effect in Pancreatic Cancer
Nanosecond Pulsed Electric Field Suppresses Growth and Reduces Multi-drug Resistance Effect in Pancreatic Cancer Open
Nanosecond pulsed electric fields (nsPEF) have been shown to exert anticancer effects; however, little is known about the mechanisms triggered in cancer cells by nanosecond-length pulses, especially when low, sub-permeabilization voltage i…
View article: The multiple uses of azelaic acid in dermatology: mechanism of action, preparations, and potential therapeutic applications
The multiple uses of azelaic acid in dermatology: mechanism of action, preparations, and potential therapeutic applications Open
Azelaic acid (AZA) is a naturally occurring saturated dicarboxylic acid whose topical application has found multiple uses in dermatology. Its anti-inflammatory, antioxidant and antimicrobial properties against Propionibacterium acne are cu…
View article: Exposure to non-opioid analgesics during pregnancy and the risk of adverse drug reactions
Exposure to non-opioid analgesics during pregnancy and the risk of adverse drug reactions Open
Therapeutic options are limited during pregnancy due to the safety of the foetus. Non-opioid analgesics (NOA) are among the most commonly prescribed medicaments by physicians. Many of them are available over-the-counter (OTC) without presc…
View article: Betulin and Its Derivatives Reduce Inflammation and COX-2 Activity in Macrophages
Betulin and Its Derivatives Reduce Inflammation and COX-2 Activity in Macrophages Open
Betulin is a heavily studied natural compound for its use as an anticancer or pro-regenerative agent. The structural similarity between betulin to steroids gives rise to the idea that the substance may as well act as an anti-inflammatory d…
View article: Electroporation in Clinical Applications—The Potential of Gene Electrotransfer and Electrochemotherapy
Electroporation in Clinical Applications—The Potential of Gene Electrotransfer and Electrochemotherapy Open
Electroporation (EP) allows for the transport of molecules into the cytoplasm with significant effectiveness by forming transient pores in the cell membrane using electric pulses. This can be used for cellular transport (RE—reversible elec…
View article: Betulin and its Derivatives Reduce Inflammation and COX-2 Activity in Macrophages
Betulin and its Derivatives Reduce Inflammation and COX-2 Activity in Macrophages Open
Betulin is a heavily studied natural compound for its use as an anticancer or pro-regenerative agent. The structural similarity of betulin to steroids gives rise to the idea, that the substance may as well act as an anti-inflammatory drug.…
View article: Boosting the Immune Response—Combining Local and Immune Therapy for Prostate Cancer Treatment
Boosting the Immune Response—Combining Local and Immune Therapy for Prostate Cancer Treatment Open
Due to its slow progression and susceptibility to radical forms of treatment, low-grade PC is associated with high overall survival (OS). With the clinical progression of PC, the therapy is becoming more complex. The immunosuppressive tumo…
View article: LAG-3 as a Potent Target for Novel Anticancer Therapies of a Wide Range of Tumors
LAG-3 as a Potent Target for Novel Anticancer Therapies of a Wide Range of Tumors Open
LAG-3 (Lymphocyte activation gene 3) protein is a checkpoint receptor that interacts with LSEC-tin, Galectin-3 and FGL1. This interaction leads to reduced production of IL-2 and IFN-γ. LAG-3 is widely expressed in different tumor types and…
View article: Targeting CD38 in Neoplasms and Non-Cancer Diseases
Targeting CD38 in Neoplasms and Non-Cancer Diseases Open
CD38 is a myeloid antigen present both on the cell membrane and in the intracellular compartment of the cell. Its occurrence is often enhanced in cancer cells, thus making it a potential target in anticancer therapy. Daratumumab and isatux…