Natalia Stepanova
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Real-world outcomes of glofitamab therapy in CAR-T naive patients with relapsed/refractory B-cell lymphoma Open
Background The bispecific antibody (BsAb) glofitamab (G) has demonstrated high efficacy and acceptable feasibility in patients with aggressive relapsed/refractory (r/r) B-cell lymphoma in clinical trials. However, real-world evidence on it…
Serum Magnesium and Risk of Arteriovenous Fistula Thrombosis in Hemodialysis: A Retrospective Cohort Study Open
Background Arteriovenous fistula (AVF) thrombosis is a major cause of vascular access failure in patients undergoing maintenance hemodialysis (HD). Although magnesium has established vascular protective properties, its relationship with AV…
Magnesium status and clinical outcomes in kidney transplant recipients: Systematic review and meta-analysis Open
Kidney transplant recipients (KTRs) remain at risk for metabolic, cardiovascular, and infectious complications. Magnesium abnormalities are common but their prognostic significance remains unclear. Objectives. To systematically review and …
Modular Strategies for Nephron Replacement and Clinical Translation Open
End-stage chronic kidney disease remains a global challenge, with dialysis and transplantation offering only partial or limited solutions. Recent advances in bioengineering have introduced modular strategies that aim to restore kidney func…
Balancing Stone Prevention and Kidney Function: A Therapeutic Dilemma Open
Managing nephrolithiasis in chronic kidney disease (CKD) poses a therapeutic challenge: preventing stone recurrence while preserving kidney function. Standard urological interventions and preventive strategies, such as high fluid intake, t…
Retrospective analysis of statin use and arteriovenous fistula thrombosis in hemodialysis: Is there a dose-dependent effect? Open
Arteriovenous fistula (AVF) thrombosis is a major vascular access complication in hemodialysis (HD) patients, contributing to increased morbidity. Statins, known for their pleiotropic effects, may reduce AVF thrombosis risk, but evidence o…
Association between serum total indoxyl sulfate, intraperitoneal inflammation, and peritoneal dialysis technique failure: a 3-year prospective cohort study Open
Our findings are the first to demonstrate a link between elevated tIS levels, peritoneal inflammation, and an increased risk of PD technique failure. Monitoring tIS levels in PD patients could be clinically relevant for risk assessment and…
Probiotic interventions in peritoneal dialysis: A review of underlying mechanisms and therapeutic potentials Open
Peritoneal dialysis (PD) is a commonly used modality for kidney replacement therapy for patients with end-stage kidney disease (ESKD). PD offers many benefits, including home-based care, greater flexibility, and preservation of residual ki…
Dyslipidemia in Peritoneal Dialysis: Implications for Peritoneal Membrane Function and Patient Outcomes Open
Dyslipidemia is a common metabolic complication in patients undergoing peritoneal dialysis (PD) and has traditionally been viewed primarily in terms of cardiovascular risk. Current guidelines do not recommend initiating lipid-lowering ther…
Pre-Infection Nutritional Status, Oxidative Stress, and One-Year-Long COVID Persistence in Patients Undergoing Hemodialysis: A Prospective Cohort Study Open
Background: Nutritional status’s role in long COVID is evident in the general population, yet unexplored in patients undergoing hemodialysis (HD), posing a research gap. We hypothesized that pre-infection undernutrition in HD patients migh…
#612 Serum citrulline level is associated with oxidative stress and chronic kidney disease progression Open
Background and Aims Citrulline, an α-amino acid crucial for the urea cycle and nitric oxide production, plays a protective role against free radicals and is indirectly related to protein metabolism. It is synthesized in the intestine and e…
Pre-infection Nutritional Status, Oxidative Stress, and One-Year Long COVID Persistence in Patients Undergoing Hemodialysis: A Prospective Cohort Study Open
Background: Nutritional status and oxidative stress have been implicated in the pathogenesis and persistence of long COVID, but data in patients undergoing hemodialysis (HD) are limited. The present study aimed to investigate the associati…
WCN24-1324 DYSLIPIDEMIA AND ULTRAFILTRATION CAPACITY IN PERITONEAL DIALYSIS: A CROSS-SECTIONAL ASSESSMENT Open
Ultrafiltration failure (UFF) and dyslipidemia are critical concerns in peritoneal dialysis (PD) associated with adverse clinical outcomes. Recent findings have linked a reduced apolipoprotein A to high-density lipoprotein cholesterol (HDL…
Hemodialysis dose and long-term COVID-19 outcomes – a retrospective cohort study Open
Introduction and aim. Long-term outcomes of COVID-19 pose a global challenge, particularly impacting individuals with un derlying health conditions, including those who have undergone hemodialysis (HD). The study aimed to investigate the r…
Association between serum total indoxyl sulfate, intraperitoneal inflammation, and peritoneal dialysis technique failure: a 3-year prospective cohort study Open
Background The impact of protein-bound uremic toxins, specifically indoxyl sulfate (IS) on peritoneal dialysis (PD) complications remains controversial. This study aimed to explore the link between serum total IS (tIS) levels, proinflammat…
Editorial: The evolution of glomerular filtration rate estimation: Embracing the new EKFC equation Open
Addressing the accurate staging of chronic kidney disease (CKD) represents a formidable challenge worldwide, resonating deeply within Ukraine's healthcare landscape. The intricacies of estimating CKD stages often result in the dilemma of i…
IL-6 and IL-17 as potential links between pre-existing hypertension and long-term COVID sequelae in patients undergoing hemodialysis: a multicenter cross-sectional study Open
Long COVID, characterized by persistent symptoms following acute infection, poses a significant health challenge, particularly for patients with pre-existing chronic conditions such as hypertension. We hypothesized that an increase in the …
Type 2 Diabetes Mellitus and the Gut Microbiota: Charting New Territory for Sodium-Glucose Co-Transporter 2 Inhibitors Open
[6] Despite the strides made in diabetes research and medical innovations, a definitive treatment for T2DM has remained elusive, necessitating ongoing exploration of novel therapeutic avenues. [2,7] mid this persistent challenge, a promisi…
LOW HIGH-DENSITY LIPOPROTEIN LEVEL ASSOCIATED WITH ENHANCED INFLAMMATORY RESPONSE AND ONE-YEAR PERSISTENCE OF LONG COVID IN PATIENTS UNDERGOING HEMODIALYSIS: A CROSS-SECTIONAL COHORT STUDY Open
Background: Long-term consequences of COVID-19, known as long COVID, present distinctive hurdles for patients receiving hemodialysis treatment. Reduced levels of high-density lipoprotein (HDL) (< 1.22 mmol/L) have previously been demonstra…
Gut Microbiota’s Oxalate-Degrading Activity and Its Implications on Cardiovascular Health in Patients with Kidney Failure: A Pilot Prospective Study Open
Background and Objectives: The present study aims to investigate the association between gut microbiota’s oxalate-degrading activity (ODA) and the risk of developing cardiovascular disease (CVD) over a three-year follow-up period in a coho…
Myeloperoxidase/paraoxonase ratio as a prognostic marker for post-COVID syndrome in patients undergoing hemodialysis: A cross-sectional cohort study Open
The present study aimed to assess the impact of post-COVID syndrome on the oxidative status and activity of paraoxonase 1 (PON-1), myeloperoxidase (MPO), and leukocyte elastase in the blood of patients undergoing hemodialysis (HD).
Method…
Oxidative stress as the bridge between dyslipidemia and peritoneal ultrafiltration failure: A bi-center cross-sectional cohort study Open
stress and dyslipidemia are common concerns in patients undergoing peritoneal dialysis (PD) and are associated with adverse clinical outcomes. However, the interplay between these factors and their impact on peritoneal ultrafiltration (UF)…
IL-6 and IL-17 as potential links between pre-existing hypertension and long-COVID sequelae in patients undergoing hemodialysis: A multicenter cross-sectional study Open
Objective. We hypothesized that an increase in the production of interleukins (IL)-6 and IL-17 could serve as a potential mechanism linking pre-existing uncontrolled blood pressure (BP) to the occurrence of long-COVID sequelae in patients …
INDICATORS OF ENERGY EFFICIENCY OF PUBLIC BUILDING Open
The relevance of paying attention to the energy efficiency of buildings, which will reduce the consumption of fossil fuels and electricity and reduce harmful emissions into the environment, is shown. The energy efficiency indicators of the…
Oxalate Homeostasis in Non-Stone-Forming Chronic Kidney Disease: A Review of Key Findings and Perspectives Open
Chronic kidney disease (CKD) is a significant global public health concern associated with high morbidity and mortality rates. The maintenance of oxalate homeostasis plays a critical role in preserving kidney health, particularly in the co…