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View article: Quiet flames: inflammation without traditional risk factors
Quiet flames: inflammation without traditional risk factors Open
View article: Occurrence of coronary events in the absence of traditional risk factors: Understanding residual risk
Occurrence of coronary events in the absence of traditional risk factors: Understanding residual risk Open
View article: Lipoprotein (a) and incident coronary heart disease in the community: impact of traditional cardiovascular risk factors
Lipoprotein (a) and incident coronary heart disease in the community: impact of traditional cardiovascular risk factors Open
Aims Deleterious effects of Lipoprotein (a) (Lp(a)) might be mitigated by overall cardiovascular (CV) risk reduction. However, data on the relationship between increased Lp(a) and incident coronary heart disease (CHD) according to the dist…
View article: Prevalence and clinical relevance of familial hypercholesterolemia-causing mutations in Germany
Prevalence and clinical relevance of familial hypercholesterolemia-causing mutations in Germany Open
Background Familial hypercholesterolemia (FH) is a monogenic disease characterized by pathogenic mutations in genes involved in low-density lipoprotein cholesterol (LDL-C) metabolism. Optimal strategies for identifying FH in the general po…
View article: Prognostic utility of high-sensitivity troponins according to atherosclerotic vascular disease severity
Prognostic utility of high-sensitivity troponins according to atherosclerotic vascular disease severity Open
Patients with a greater extent of ASVD had higher concentrations of hsTnT/I and an increased incidence of all-cause mortality as well as MACE. hsTnT/I concentrations were reliably linked to all-cause mortality in patients with ASVD, unders…
View article: Inflammation in atherosclerotic cardiovascular disease: From diagnosis to treatment
Inflammation in atherosclerotic cardiovascular disease: From diagnosis to treatment Open
Background Targeting inflammation offers a unique possibility to address residual cardiovascular risk in almost two thirds of all patients with prevalent atherosclerotic cardiovascular disease (ASCVD). However, despite FDA approval and the…
View article: Association of modifiable lifestyle risk factors with high-sensitivity troponin T and I concentrations and clinical outcomes
Association of modifiable lifestyle risk factors with high-sensitivity troponin T and I concentrations and clinical outcomes Open
Aims We aimed to investigate the association between the burden of modifiable lifestyle risk factors (modLRF) with high-sensitivity cardiac troponins T and I (hsTnT/I) and clinical outcomes in a contemporary cohort. Methods and results Pat…
View article: Correction to: Polygenic Risk Score: Clinically Useful Tool for Prediction of Cardiovascular Disease and Benefit from Lipid-Lowering Therapy?
Correction to: Polygenic Risk Score: Clinically Useful Tool for Prediction of Cardiovascular Disease and Benefit from Lipid-Lowering Therapy? Open
View article: Sex differences in lipidomic and bile acid plasma profiles in patients with and without coronary artery disease
Sex differences in lipidomic and bile acid plasma profiles in patients with and without coronary artery disease Open
View article: Infection, inflammation, and cardiovascular risk: are we underestimating an old disease?
Infection, inflammation, and cardiovascular risk: are we underestimating an old disease? Open
Graphical AbstractOpen in new tabDownload slideFacing the public health threat: syphilis resurgence and cardiovascular risk
View article: Night shift work and cardiovascular diseases among employees in Germany: five-year follow-up of the Gutenberg Health Study
Night shift work and cardiovascular diseases among employees in Germany: five-year follow-up of the Gutenberg Health Study Open
OBJECTIVE: This study aimed to determine if there is an increased risk of incident cardiovascular diseases (CVD) resulting from cumulative night shift work in the German population-based Gutenberg Health Study (GHS). METHODS: We examined w…
View article: Publisher Correction: Inflammatory burden, lifestyle and atherosclerotic cardiovascular disease: insights from a population based cohort study
Publisher Correction: Inflammatory burden, lifestyle and atherosclerotic cardiovascular disease: insights from a population based cohort study Open
View article: Inflammatory burden, lifestyle and atherosclerotic cardiovascular disease: insights from a population based cohort study
Inflammatory burden, lifestyle and atherosclerotic cardiovascular disease: insights from a population based cohort study Open
View article: Lipid Lowering Drugs in Acute Coronary Syndromes (ACS)
Lipid Lowering Drugs in Acute Coronary Syndromes (ACS) Open
View article: Modifiable risk factors and inflammatory burden stratified by the presence and extent of atherosclerotic cardiovascular disease: insights from a population based cohort study
Modifiable risk factors and inflammatory burden stratified by the presence and extent of atherosclerotic cardiovascular disease: insights from a population based cohort study Open
Background/Introduction Inflammation is recognized as a residual risk factor and mediator in patients with Atherosclerotic Cardiovascular Disease (ASCVD). High-sensitivity C-Reactive Protein (hsCRP), a marker of systemic inflammation, can …
View article: Evaluating risk-based allocation strategies for PCSK9 inhibitors: results from a simulation study in a contemporary ASCVD cohort
Evaluating risk-based allocation strategies for PCSK9 inhibitors: results from a simulation study in a contemporary ASCVD cohort Open
Background/Aim Targeting PCSK9 inhibitors (PCSK9i) to patients with high LDL-cholesterol (LDL-C) as well as a high cardiovascular event rate yields the highest therapeutic effect and is thus reasonable from a health economic perspective. T…
View article: Can the association between LDL-Cholesterol and incident coronary heart disease (CHD) be modulated by concomitant Lp(a) levels in the general population?
Can the association between LDL-Cholesterol and incident coronary heart disease (CHD) be modulated by concomitant Lp(a) levels in the general population? Open
Background LDL-cholesterol (LDL-C), quantified by conventional methods, also includes the choles-terol attributable to Lipoprotein (a) (Lp(a)-C) due to their overlapping densities. The clinical relevance of this is still poorly investigate…
View article: Familial Hypercholesterolemia: Pitfalls and Challenges in Diagnosis and Treatment
Familial Hypercholesterolemia: Pitfalls and Challenges in Diagnosis and Treatment Open
Familial hypercholesterolemia (FH), a condition, which is characterized by a life-long exposure to markedly elevated low-density lipoprotein (LDL) concentrations from birth, and it still remains underdiagnosed and undertreated, despite the…
View article: Effects of empagliflozin on left ventricular diastolic function in addition to usual care in individuals with type 2 diabetes mellitus—results from the randomized, double-blind, placebo-controlled EmDia trial
Effects of empagliflozin on left ventricular diastolic function in addition to usual care in individuals with type 2 diabetes mellitus—results from the randomized, double-blind, placebo-controlled EmDia trial Open
View article: Lower levels of vWF are associated with lower risk of cardiovascular disease
Lower levels of vWF are associated with lower risk of cardiovascular disease Open
View article: PCSK9 Inhibitor Wars: How Does Inclisiran Fit in with Current Monoclonal Antibody Inhibitor Therapy? Considerations for Patient Selection
PCSK9 Inhibitor Wars: How Does Inclisiran Fit in with Current Monoclonal Antibody Inhibitor Therapy? Considerations for Patient Selection Open
Purpose of Review Treatment of dyslipidemia represents one of the most crucial strategies to reduce risk of atherosclerotic cardiovascular (CV) disease (ASCVD). In this review, we critically summarize our knowledge on emerging cholesterol-…
View article: Chronic cigarette smoking is associated with increased arterial stiffness in men and women: evidence from a large population-based cohort
Chronic cigarette smoking is associated with increased arterial stiffness in men and women: evidence from a large population-based cohort Open
Background Cigarette smoking is a threat to global human health and a leading cause of the cardiovascular disease (CVD) morbidity and mortality. Importantly, sex-specific differences in smoking-induced arterial stiffness, an early key even…
View article: Relationships between coagulation factors and thrombin generation in a general population with arterial and venous disease background
Relationships between coagulation factors and thrombin generation in a general population with arterial and venous disease background Open
View article: Renin, aldosterone, the aldosterone-to-renin ratio, and incident hypertension among normotensive subjects from the general population
Renin, aldosterone, the aldosterone-to-renin ratio, and incident hypertension among normotensive subjects from the general population Open
Aims To investigate the predictive ability of direct plasma renin and aldosterone concentrations as well as their ratio [aldosterone-to-renin (ARR)] for incident hypertension in the general population. Methods and results Concentration of …
View article: Biochemical determinants of thrombin generation in a general population with arterial and venous disease background
Biochemical determinants of thrombin generation in a general population with arterial and venous disease background Open
Background: The current study aims to identify the biochemical determinants of plasma thrombin generation in a large population-based study by comparing individuals with a history of arterial or venous thrombosis to cardiovascular healthy …
View article: Long working hours and risk of cardiovascular outcomes and diabetes type II: five-year follow-up of the Gutenberg Health Study (GHS)
Long working hours and risk of cardiovascular outcomes and diabetes type II: five-year follow-up of the Gutenberg Health Study (GHS) Open
Objectives The aims of this study were to determine if there was an increased risk of incident cardiovascular disease (CVD) and diabetes and an increase in arterial stiffness in participants who reported working 41–54 h per week and more t…
View article: Correction: Work-life conflict and cardiovascular health: 5-year follow-up of the Gutenberg Health Study
Correction: Work-life conflict and cardiovascular health: 5-year follow-up of the Gutenberg Health Study Open
[This corrects the article DOI: 10.1371/journal.pone.0251260.].
View article: Chronic venous insufficiency, cardiovascular disease, and mortality: a population study
Chronic venous insufficiency, cardiovascular disease, and mortality: a population study Open
Aims Evidence regarding the health burden of chronic venous insufficiency (CVI), its clinical determinants, and impact on outcome is scarce. Methods and results Systematic phenotyping of CVI according to established CEAP (Clinical-Etiologi…
View article: Domains of Physical Activity in Relation to Stiffness Index in the General Population
Domains of Physical Activity in Relation to Stiffness Index in the General Population Open
Background Regular exercise training represents an important modifier of arterial stiffness (AS). Therefore, sex‐specific relations between domains of physical activity (PA; commuting, domestic, and leisure‐time PA, including active sport …
View article: Correction to: Self‑reported cardiovascular health of teachers: results from the 5‑year follow‑up of the Gutenberg Health Study cohort
Correction to: Self‑reported cardiovascular health of teachers: results from the 5‑year follow‑up of the Gutenberg Health Study cohort Open