Natalie J. Kirkland
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View article: Vinculin Haploinsufficiency Impairs Integrin-Mediated Costamere Remodeling to Changing Microenvironments
Vinculin Haploinsufficiency Impairs Integrin-Mediated Costamere Remodeling to Changing Microenvironments Open
View article: Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity
Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity Open
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with a likely oligogenic etiology, but our understanding of the genetic complexities and pathogenic mechanisms leading to HLHS is limited. We performed whole…
View article: Author response: Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity
Author response: Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Hypopla…
View article: Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs
Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs Open
View article: Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity
Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity Open
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with a likely oligogenic etiology, but our understanding of the genetic complexities and pathogenic mechanisms leading to HLHS is limited. We therefore perfo…
View article: Subcellular Remodeling in Filamin C Deficient Mouse Hearts Impairs Myocyte Tension Development during Progression of Dilated Cardiomyopathy
Subcellular Remodeling in Filamin C Deficient Mouse Hearts Impairs Myocyte Tension Development during Progression of Dilated Cardiomyopathy Open
Dilated cardiomyopathy (DCM) is a life-threatening form of heart disease that is typically characterized by progressive thinning of the ventricular walls, chamber dilation, and systolic dysfunction. Multiple mutations in the gene encoding …
View article: Age-dependent Lamin remodeling induces cardiac dysfunction via dysregulation of cardiac transcriptional programs
Age-dependent Lamin remodeling induces cardiac dysfunction via dysregulation of cardiac transcriptional programs Open
As we age, structural changes contribute to progressive decline in organ function, which in the heart acts through poorly characterized mechanisms. Utilizing the rapidly aging fruit fly model with its significant homology to the human card…
View article: Author Correction: Community-driven online initiatives have reshaped scientific engagement
Author Correction: Community-driven online initiatives have reshaped scientific engagement Open
View article: Community-driven online initiatives have reshaped scientific engagement
Community-driven online initiatives have reshaped scientific engagement Open
View article: Atomic Force Microscopy for Live-Cell and Hydrogel Measurement
Atomic Force Microscopy for Live-Cell and Hydrogel Measurement Open
View article: Tissue Mechanics Regulate Mitotic Nuclear Dynamics during Epithelial Development
Tissue Mechanics Regulate Mitotic Nuclear Dynamics during Epithelial Development Open
Cell divisions are essential for tissue growth. In pseudostratified epithelia, where nuclei are staggered across the tissue, each nucleus migrates apically before undergoing mitosis. Successful apical nuclear migration is critical for plan…
View article: Planar Differential Growth Rates Initiate Precise Fold Positions in Complex Epithelia
Planar Differential Growth Rates Initiate Precise Fold Positions in Complex Epithelia Open
Tissue folding is a fundamental process that shapes epithelia into complex 3D organs. The initial positioning of folds is the foundation for the emergence of correct tissue morphology. Mechanisms forming individual folds have been studied,…
View article: Tissue mechanics regulate mitotic nuclear dynamics during epithelial development
Tissue mechanics regulate mitotic nuclear dynamics during epithelial development Open
Summary Cell divisions are essential for tissue growth. In pseudostratified epithelia, where nuclei are staggered across the tissue, each nucleus migrates apically before undergoing mitosis. Successful apical nuclear migration is critical …
View article: Planar differential growth rates determine the position of folds in complex epithelia
Planar differential growth rates determine the position of folds in complex epithelia Open
Summary Folding is a fundamental process shaping epithelial sheets into 3D architectures of organs. Initial positioning of folds is the foundation for the emergence of correct tissue morphology. Mechanisms forming individual folds have bee…
View article: Polarization of Myosin II Refines Tissue Material Properties to Buffer Mechanical Stress
Polarization of Myosin II Refines Tissue Material Properties to Buffer Mechanical Stress Open
As tissues develop, they are subjected to a variety of mechanical forces. Some of these forces are instrumental in the development of tissues, while others can result in tissue damage. Despite our extensive understanding of force-guided mo…