Natalie R. Hasbani
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View article: A multi-trait genome-wide association study of coronary artery disease and subclinical atherosclerosis traits
A multi-trait genome-wide association study of coronary artery disease and subclinical atherosclerosis traits Open
Measures of subclinical atherosclerosis, such as coronary artery calcification (CAC) and carotid intima-media thickness (CIMT), reflect the underlying pathophysiology of coronary artery disease (CAD) and are genetically correlated with CAD…
View article: Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness
Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness Open
Carotid artery intima-media thickness (cIMT) is a measurement of subclinical atherosclerosis that predicts future cardiovascular events, including stroke and myocardial infarction. Genome-wide association studies (GWAS) have identified onl…
View article: Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk
Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk Open
Background Previous work has shown a role of CCL2, a key chemokine governing monocyte trafficking, in atherosclerosis. However, it remains unknown whether targeting CCR2, the cognate receptor of CCL2, provides protection against human athe…
View article: Unveiling the Genetic Landscape of Coronary Artery Disease Through Common and Rare Structural Variants
Unveiling the Genetic Landscape of Coronary Artery Disease Through Common and Rare Structural Variants Open
Background Genome‐wide association studies have identified several hundred susceptibility single nucleotide variants for coronary artery disease (CAD). Despite single nucleotide variant‐based genome‐wide association studies improving our u…
View article: Rare variant contribution to the heritability of coronary artery disease
Rare variant contribution to the heritability of coronary artery disease Open
Whole genome sequences (WGS) enable discovery of rare variants which may contribute to missing heritability of coronary artery disease (CAD). To measure their contribution, we apply the GREML-LDMS-I approach to WGS of 4949 cases and 17,494…
View article: Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes
Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes Open
OBJECTIVE To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We conducted a multiancestry time-to-event genome-wide association study for incident…
View article: <b>Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus</b>
<b>Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus</b> Open
OBJECTIVE To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We conducted a multi-ancestry time-to-event genome-wide association study for inciden…
View article: <b>Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus</b>
<b>Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus</b> Open
OBJECTIVE To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We conducted a multi-ancestry time-to-event genome-wide association study for inciden…
View article: Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification
Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification Open
View article: Type 2 Diabetes Modifies the Association of CAD Genomic Risk Variants With Subclinical Atherosclerosis
Type 2 Diabetes Modifies the Association of CAD Genomic Risk Variants With Subclinical Atherosclerosis Open
BACKGROUND: Individuals with type 2 diabetes (T2D) have an increased risk of coronary artery disease (CAD), but questions remain about the underlying pathology. Identifying which CAD loci are modified by T2D in the development of subclinic…
View article: Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification
Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification Open
View article: Rare damaging<i>CCR2</i>variants are associated with lower lifetime cardiovascular risk
Rare damaging<i>CCR2</i>variants are associated with lower lifetime cardiovascular risk Open
Background Previous work has shown a role of CCL2, a key chemokine governing monocyte trafficking, in atherosclerosis. However, it remains unknown whether targeting CCR2, the cognate receptor of CCL2, provides protection against human athe…
View article: Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus
Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus Open
BACKGROUND Type 2 diabetes mellitus (T2D) confers a two- to three-fold increased risk of cardiovascular disease (CVD). However, the mechanisms underlying increased CVD risk among people with T2D are only partially understood. We hypothesiz…
View article: Coronary heart disease and ischemic stroke polygenic risk scores and atherosclerotic cardiovascular disease in a diverse, population-based cohort study
Coronary heart disease and ischemic stroke polygenic risk scores and atherosclerotic cardiovascular disease in a diverse, population-based cohort study Open
The predictive ability of coronary heart disease (CHD) and ischemic stroke (IS) polygenic risk scores (PRS) have been evaluated individually, but whether they predict the combined outcome of atherosclerotic cardiovascular disease (ASCVD) r…
View article: Investigating Gene–Diet Interactions Impacting the Association Between Macronutrient Intake and Glycemic Traits
Investigating Gene–Diet Interactions Impacting the Association Between Macronutrient Intake and Glycemic Traits Open
Few studies have demonstrated reproducible gene–diet interactions (GDIs) impacting metabolic disease risk factors, likely due in part to measurement error in dietary intake estimation and insufficient capture of rare genetic variation. We …
View article: Investigating gene-diet interactions impacting the association between macronutrient intake and glycemic traits
Investigating gene-diet interactions impacting the association between macronutrient intake and glycemic traits Open
Few studies have demonstrated reproducible gene-diet interactions (GDIs) impacting metabolic disease risk factors, likely due in part to measurement error in dietary intake estimation and insufficient capture of rare genetic variation. We …
View article: Investigating gene-diet interactions impacting the association between macronutrient intake and glycemic traits
Investigating gene-diet interactions impacting the association between macronutrient intake and glycemic traits Open
Few studies have demonstrated reproducible gene-diet interactions (GDIs) impacting metabolic disease risk factors, likely due in part to measurement error in dietary intake estimation and insufficient capture of rare genetic variation. We …
View article: Coronary heart disease and ischemic stroke polygenic risk scores and atherosclerotic cardiovascular disease in a diverse, population-based cohort study
Coronary heart disease and ischemic stroke polygenic risk scores and atherosclerotic cardiovascular disease in a diverse, population-based cohort study Open
The predictive ability of coronary heart disease (CHD) and ischemic stroke (IS) polygenic risk scores (PRS) have been evaluated individually, but whether they predict the combined outcome of atherosclerotic cardiovascular disease (ASCVD) r…
View article: Investigating gene-diet interactions impacting the association between macronutrient intake and glycemic traits
Investigating gene-diet interactions impacting the association between macronutrient intake and glycemic traits Open
Background Heterogeneity in the long-term metabolic response to dietary macronutrient composition can be partially explained by genetic factors. However, few studies have demonstrated reproducible gene-diet interactions (GDIs), likely due …
View article: Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program
Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program Open
View article: Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 individuals Across 13 Cohorts
Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 individuals Across 13 Cohorts Open
Objective: Type 2 diabetes (T2D) has heterogeneous patient clinical characteristics and outcomes. In previous work we investigated the genetic basis of this heterogeneity by clustering 94 T2D genetic loci using their associations wi…
View article: Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 Cohorts
Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 Cohorts Open
OBJECTIVE Type 2 diabetes (T2D) has heterogeneous patient clinical characteristics and outcomes. In previous work, we investigated the genetic basis of this heterogeneity by clustering 94 T2D genetic loci using their associations with 47 d…
View article: Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 individuals Across 13 Cohorts
Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 individuals Across 13 Cohorts Open
Objective: Type 2 diabetes (T2D) has heterogeneous patient clinical characteristics and outcomes. In previous work we investigated the genetic basis of this heterogeneity by clustering 94 T2D genetic loci using their associations wi…
View article: Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program
Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program Open
The genetic determinants of fasting glucose (FG) and fasting insulin (FI) have been studied mostly through genome arrays, resulting in over 100 associated variants. We extended this work with high-coverage whole genome sequencing analyses …
View article: Genetic susceptibility, obesity and lifetime risk of type 2 diabetes: The ARIC study and Rotterdam Study
Genetic susceptibility, obesity and lifetime risk of type 2 diabetes: The ARIC study and Rotterdam Study Open
Aims Both lifestyle factors and genetic background contribute to the development of type 2 diabetes. Estimation of the lifetime risk of diabetes based on genetic information has not been presented, and the extent to which a normal body wei…
View article: Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program
Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program Open
The genetic determinants of fasting glucose (FG) and fasting insulin (FI) have been studied mostly through genome and exome arrays, resulting in over 100 associated variants. We extended this work with a high-coverage whole genome sequenci…
View article: Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes
Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes Open
Type 2 diabetes is increasing in all ancestry groups 1 . Part of its genetic basis may reside among the rare (minor allele frequency <0.1%) variants that make up the vast majority of human genetic variation 2 . We analyzed high-coverage (m…
View article: Table of Contents
Table of Contents Open
View article: Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control
Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control Open
View article: Early Enteral Nutrition Is Associated With Improved Clinical Outcomes in Critically Ill Children: A Secondary Analysis of Nutrition Support in the Heart and Lung Failure-Pediatric Insulin Titration Trial
Early Enteral Nutrition Is Associated With Improved Clinical Outcomes in Critically Ill Children: A Secondary Analysis of Nutrition Support in the Heart and Lung Failure-Pediatric Insulin Titration Trial Open
Objectives: The impact of early enteral nutrition on clinical outcomes in critically ill children has not been adequately described. We hypothesized that early enteral nutrition is associated with improved clinical outcomes in critically i…