Natalie S. Adamczyk
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View article: CD14 plays a critical role in pain and inflammation across multiple models of post-traumatic osteoarthritis
CD14 plays a critical role in pain and inflammation across multiple models of post-traumatic osteoarthritis Open
Inflammation is a primary driver of osteoarthritis (OA), and no therapies exist to halt or delay disease progression or substantially ameliorate the chronic pain, inflammation and disability that are characteristic of disease. Soluble CD14…
View article: CXCL16 mediates nociception and inflammation in murine post-traumatic osteoarthritis
CXCL16 mediates nociception and inflammation in murine post-traumatic osteoarthritis Open
This study investigates the role of the chemokine CXCL16 and its receptor, CXCR6, in post-traumatic osteoarthritis (PTOA) and joint nociception, highlighting the potential of targeting the CXCL16-CXCR6 axis for therapeutically managing joi…
View article: FM-dye inhibition of Piezo2 relieves acute inflammatory and osteoarthritis knee pain in mice of both sexes
FM-dye inhibition of Piezo2 relieves acute inflammatory and osteoarthritis knee pain in mice of both sexes Open
Musculoskeletal pain is a significant burden affecting billions of people with little progress in the development of pharmaceutical pain relief options. The mechanically-activated ion channel Piezo2 has been shown to play a role in mechani…
View article: Extended osteoarthritis pain relief with neosaxitoxin using alginate-core polymeric microparticles
Extended osteoarthritis pain relief with neosaxitoxin using alginate-core polymeric microparticles Open
We developed a sustained release alginate-core polymeric microparticle formulation (NSTX-AlgPLGA-MP) to extend the analgesic effect of Neosaxitoxin (NSTX) for osteoarthritis (OA) pain from hours to approximately one week.
View article: Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage
Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage Open
View article: Clearing‐enabled light sheet microscopy as a novel method for three‐dimensional mapping of the sensory innervation of the mouse knee
Clearing‐enabled light sheet microscopy as a novel method for three‐dimensional mapping of the sensory innervation of the mouse knee Open
A major barrier that hampers our understanding of the precise anatomic distribution of pain sensing nerves in and around the joint is the limited view obtained from traditional two dimensional (D) histological approaches. Therefore, our ob…
View article: Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage
Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage Open
Background Osteoarthritis (OA) is a painful degenerative joint disease and a leading source of years lived with disability globally due to inadequate treatment options. Neuroimmune interactions reportedly contribute to OA pain pathogenesis…
View article: Intra-articular sprouting of nociceptors accompanies progressive osteoarthritis: comparative evidence in four murine models
Intra-articular sprouting of nociceptors accompanies progressive osteoarthritis: comparative evidence in four murine models Open
Objective Knee joints are densely innervated by nociceptors. In human knees and rodent models, sprouting of nociceptors has been reported in late-stage osteoarthritis (OA). Here, we sought to describe progressive nociceptor remodeling in e…
View article: Clearing-enabled light sheet microscopy as a novel method for three-dimensional mapping of the sensory innervation of the mouse knee
Clearing-enabled light sheet microscopy as a novel method for three-dimensional mapping of the sensory innervation of the mouse knee Open
A major barrier that hampers our understanding of the precise anatomic distribution of pain sensing nerves in and around the joint is the limited view obtained from traditional two dimensional (D) histological approaches. Therefore, our ob…
View article: Reduced Capsaicin-Induced Mechanical Allodynia and Neuronal Responses in the DRG in the Presence of<i>Shp1</i>Overexpression
Reduced Capsaicin-Induced Mechanical Allodynia and Neuronal Responses in the DRG in the Presence of<i>Shp1</i>Overexpression Open
Transient Receptor Potential Vanilloid 1 (TRPV1) is a nonselective cation channel expressed by pain-sensing neurons and has been an attractive target for the development of drugs to treat pain. Recently, Src homology region 2 domain-contai…
View article: Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression
Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression Open
Transient Receptor Potential Vanilloid 1 (TRPV1) is a nonselective cation channel expressed by pain-sensing neurons and has been an attractive target for the development of drugs to treat pain. Recently, Src homology region two domain-cont…
View article: Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis
Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis Open
Non-opioid targets are needed for addressing osteoarthritis pain, which is mechanical in nature and associated with daily activities such as walking and climbing stairs. Piezo2 has been implicated in the development of mechanical pain, but…
View article: Improved Functional Outcome After Peripheral Nerve Stimulation of the Impaired Forelimb Post-stroke
Improved Functional Outcome After Peripheral Nerve Stimulation of the Impaired Forelimb Post-stroke Open
Lack of blood flow to the brain, i.e., ischemic stroke, results in loss of nerve cells and therefore loss of function in the effected brain regions. There is no effective treatment to improve lost function except restoring blood flow withi…
View article: Dentate Gyrus Proliferative Responses After Traumatic Brain Injury and Binge Alcohol in Adult Rats
Dentate Gyrus Proliferative Responses After Traumatic Brain Injury and Binge Alcohol in Adult Rats Open
Background: Traumatic brain injury is a significant public health issue that results in serious disability in survivors. Traumatic brain injury patients are often intoxicated with alcohol when admitted to the hospital; however, it is not c…