Nataliya Slater
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View article: Altered Transcriptome Signature in Primary Human Myotubes Exposed to Inclusion Body Myositis Serum: A Pilot Case Comparison of Anti-cN1A Positive and Negative Sera
Altered Transcriptome Signature in Primary Human Myotubes Exposed to Inclusion Body Myositis Serum: A Pilot Case Comparison of Anti-cN1A Positive and Negative Sera Open
Inclusion body myositis (IBM) is a late-onset, treatment-resistant inflammatory myopathy. Approximately half of IBM patients develop autoantibodies against cytosolic 5′-nucleotidase 1A (cN1A), but their role in disease pathogenesis remains…
View article: Expression and Site-Specific Biotinylation of Human Cytosolic 5′-Nucleotidase 1A in Escherichia coli
Expression and Site-Specific Biotinylation of Human Cytosolic 5′-Nucleotidase 1A in Escherichia coli Open
Autoantibodies targeting cytosolic 5′-nucleotidase 1A (cN1A) are found in several autoimmune diseases, including inclusion body myositis (IBM), Sjögren’s syndrome, and systemic lupus erythematosus. While they have diagnostic relevance for …
View article: Balancing Clinical Applicability and Scientific Depth in ML Models for MDA5-DM Prognosis
Balancing Clinical Applicability and Scientific Depth in ML Models for MDA5-DM Prognosis Open
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View article: Identification of distinct immune signatures in inclusion body myositis by peripheral blood immunophenotyping using machine learning models
Identification of distinct immune signatures in inclusion body myositis by peripheral blood immunophenotyping using machine learning models Open
Objective Inclusion body myositis (IBM) is a progressive late‐onset muscle disease characterised by preferential weakness of quadriceps femoris and finger flexors, with elusive causes involving immune, degenerative, genetic and age‐related…
View article: High-resolution HLA genotyping in inclusion body myositis refines 8.1 ancestral haplotype association to DRB1*03:01:01 and highlights pathogenic role of arginine-74 of DRβ1 chain
High-resolution HLA genotyping in inclusion body myositis refines 8.1 ancestral haplotype association to DRB1*03:01:01 and highlights pathogenic role of arginine-74 of DRβ1 chain Open
High-resolution HLA sequencing more precisely characterised the alleles associated with IBM and defined a haplotype linked to earlier disease onset. Identification of the critical amino acid residue by advanced biostatistical analysis of i…
View article: From data to diagnosis: how machine learning is revolutionizing biomarker discovery in idiopathic inflammatory myopathies
From data to diagnosis: how machine learning is revolutionizing biomarker discovery in idiopathic inflammatory myopathies Open
Idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of muscle disorders including adult and juvenile dermatomyositis, polymyositis, immune-mediated necrotising myopathy and sporadic inclusion body myositis, all of which pre…
View article: Uncovering the significance of expanded CD8+ large granular lymphocytes in inclusion body myositis: Insights into T cell phenotype and functional alterations, and disease severity
Uncovering the significance of expanded CD8+ large granular lymphocytes in inclusion body myositis: Insights into T cell phenotype and functional alterations, and disease severity Open
Introduction Inclusion body myositis (IBM) is a progressive inflammatory myopathy characterised by skeletal muscle infiltration and myofibre invasion by CD8 + T lymphocytes. In some cases, IBM has been reported to be associated with a syst…
View article: Inclusion body myositis: The interplay between ageing, muscle degeneration and autoimmunity
Inclusion body myositis: The interplay between ageing, muscle degeneration and autoimmunity Open
Inclusion body myositis (IBM) is a slowly progressive muscle disease affecting ageing individuals. IBM presents with a distinctive pattern of weakness involving the quadriceps and finger flexor muscles, although other muscles including pha…
View article: Immunoregulatory effects of testosterone supplementation combined with exercise training in men with Inclusion Body Myositis: a double‐blind, placebo‐controlled, cross‐over trial
Immunoregulatory effects of testosterone supplementation combined with exercise training in men with Inclusion Body Myositis: a double‐blind, placebo‐controlled, cross‐over trial Open
Objectives Sporadic Inclusion Body Myositis (IBM) is an inflammatory muscle disease affecting individuals over the age of 45, leading to progressive muscle wasting, disability and loss of independence. Histologically, IBM is characterised …
View article: Isolation of Live Leukocytes from Human Inflammatory Muscles
Isolation of Live Leukocytes from Human Inflammatory Muscles Open
In inflammatory myopathies, the self-reactive immune cells involved in muscle aggression have been studied mostly using histological assessment of muscle biopsy sections; this methodology provides the advantage of visualizing and identifyi…
View article: In vitro selection of DNA aptamers that neutralise autoantibodies to cytosolic 5’-nucleotidase-1A
In vitro selection of DNA aptamers that neutralise autoantibodies to cytosolic 5’-nucleotidase-1A Open
Background. Inclusion Body Myositis (IBM) is the most commonly diagnosed inflammatory muscle disease associated with aging. It’s characterised by degeneration of skeletal muscles that inevitably leads to the loss of mobility. The mechanism…