Natasha N. Knier
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View article: Inside Back Cover: The careful selection of zwitterionic nanoparticle coating results in rapid and efficient cell labeling for imaging‐based cell tracking
Inside Back Cover: The careful selection of zwitterionic nanoparticle coating results in rapid and efficient cell labeling for imaging‐based cell tracking Open
View article: Pharmacological Inhibition of Endogenous Hydrogen Sulfide Production Slows Bladder Cancer Progression in an Intravesical Murine Model
Pharmacological Inhibition of Endogenous Hydrogen Sulfide Production Slows Bladder Cancer Progression in an Intravesical Murine Model Open
Present bladder cancer therapies have relatively limited therapeutic impact and account for one of the highest lifetime treatment costs per patient. Therefore, there is an urgent need to explore novel and optimized treatment strategies. Th…
View article: The careful selection of zwitterionic nanoparticle coating results in rapid and efficient cell labeling for imaging‐based cell tracking
The careful selection of zwitterionic nanoparticle coating results in rapid and efficient cell labeling for imaging‐based cell tracking Open
The increased clinical application of cell‐based therapies has resulted in a parallel increase in the need for non‐invasive imaging‐based approaches for cell tracking, often through labeling with nanoparticles. An ideal nanoparticle for su…
View article: Preclinical Models of Brain Metastases in Breast Cancer
Preclinical Models of Brain Metastases in Breast Cancer Open
Breast cancer remains a leading cause of mortality among women worldwide. Brain metastases confer extremely poor prognosis due to a lack of understanding of their specific biology, unique physiologic and anatomic features of the brain, and…
View article: MAIT cells accumulate in ovarian cancer-elicited ascites where they retain their capacity to respond to MR1 ligands and cytokine cues
MAIT cells accumulate in ovarian cancer-elicited ascites where they retain their capacity to respond to MR1 ligands and cytokine cues Open
View article: A method for the efficient iron-labeling of patient-derived xenograft cells and cellular imaging validation
A method for the efficient iron-labeling of patient-derived xenograft cells and cellular imaging validation Open
There is momentum towards implementing patient-derived xenograft models (PDX) in cancer research to reflect the histopathology, tumor behavior, and metastatic properties observed in the original tumor. These models are more predictive of c…
View article: A method for the efficient iron-labeling of patient-derived xenograft cells and cellular imaging validation
A method for the efficient iron-labeling of patient-derived xenograft cells and cellular imaging validation Open
There is momentum towards implementing patient-derived xenograft models (PDX) in cancer research to reflect the histopathology, tumour behavior, and metastatic properties observed in the original tumour. These models are more predictive of…
View article: A Perspective on Cell Tracking with Magnetic Particle Imaging
A Perspective on Cell Tracking with Magnetic Particle Imaging Open
Many labs have been developing cellular magnetic resonance imaging (MRI), using both superparamagnetic iron oxide nanoparticles (SPIONs) and fluorine-19 (19F)-based cell labels, to track immune and stem cells used for cellular therapies. A…
View article: A Perspective on Cell Tracking with Magnetic Particle Imaging
A Perspective on Cell Tracking with Magnetic Particle Imaging Open
Magnetic Particle Imaging (MPI) is a new imaging modality that sensitively and specifically detects superparamagnetic iron oxide nanoparticles (SPIONs). Many labs have been developing cellular magnetic resonance imaging (MRI) tools using b…
View article: Development of Magnetic Particle Imaging (MPI) for Cell Tracking and Detection
Development of Magnetic Particle Imaging (MPI) for Cell Tracking and Detection Open
Introduction Magnetic particle imaging (MPI) is a new imaging modality that sensitively and specifically detects superparamagnetic iron oxide nanoparticles (SPIONs) within a sample. SPION-based MRI cell tracking has very high sensitivity, …
View article: Comparing the Fate of Brain Metastatic Breast Cancer Cells in Different Immune Compromised Mice with Cellular Magnetic Resonance Imaging
Comparing the Fate of Brain Metastatic Breast Cancer Cells in Different Immune Compromised Mice with Cellular Magnetic Resonance Imaging Open
Metastasis is the leading cause of mortality in breast cancer patients, with brain metastases becoming increasingly prevalent. Studying this disease is challenging due to the limited experimental models and methods available. Here, we used…
View article: Engineering Circulating Tumor Cells as Novel Cancer Theranostics
Engineering Circulating Tumor Cells as Novel Cancer Theranostics Open
New ways to target and treat metastatic disease are urgently needed. Tumor "self-homing" describes the recruitment of circulating tumor cells (CTCs) back to a previously excised primary tumor location, contributing to tumor recurrence, as …