Natasha Speight
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View article: Infection-Induced Telomere Length Variation: Insights into Pathogenesis of Koala Retrovirus
Infection-Induced Telomere Length Variation: Insights into Pathogenesis of Koala Retrovirus Open
The pathogenesis of koala retrovirus (KoRV) has been explored in various contexts, yet its role in tumorigenesis remains incompletely understood. Unlike acute transforming retroviruses, KoRV lacks a viral oncogene but may contribute to onc…
View article: Biochemical Reference Intervals of Free‐Ranging Koalas (<scp><i>Phascolarctos cinereus</i></scp>) in South Australia
Biochemical Reference Intervals of Free‐Ranging Koalas (<span><i>Phascolarctos cinereus</i></span>) in South Australia Open
Background Reference intervals ( RIs ) are an essential tool for assessment of clinical pathology data of animals, and are particularly important for monitoring the health status of free‐ranging and captive wildlife, such as koalas ( Phasc…
View article: Reference Values for Postmortem Examination of the Heart in the Macropod (Macropodidae) and Koala (Phascolarctidae)
Reference Values for Postmortem Examination of the Heart in the Macropod (Macropodidae) and Koala (Phascolarctidae) Open
Morphometric cardiac reference values are reported for macropods and koalas (Phascolarctos cinereus). Body weight (BW), heart weight (HW), left ventricle (LV) wall, interventricular septum (S), right ventricle (RV) wall thickness, and LV+S…
View article: Prognostic factors in bushfire‐affected koalas–Kangaroo Island bushfire response 2020
Prognostic factors in bushfire‐affected koalas–Kangaroo Island bushfire response 2020 Open
This study presents a retrospective analysis of clinical records data from koalas presenting for treatment following the large‐scale bushfire event on Kangaroo Island 2019–2020. The aim of the study was to identify prognostic factors for k…
View article: Cutaneous and Respiratory Lesions in Bushfire-Affected Koalas
Cutaneous and Respiratory Lesions in Bushfire-Affected Koalas Open
In the wake of increasingly frequent bushfires emerging as a threat to wildlife worldwide, koalas have notably been the most rescued species in Australia. However, our understanding of burns and their severity in koalas is limited; hence, …
View article: Koala retrovirus infection and disease in South Australian koala (Phascolarctos cinereus) populations. In Proceedings of the Second Koala Retrovirus Workshop, ed. D. E. Alquezar-Planas, D. P. Higgins, C. L. Singleton, and A. D. Greenwood
Koala retrovirus infection and disease in South Australian koala (Phascolarctos cinereus) populations. In Proceedings of the Second Koala Retrovirus Workshop, ed. D. E. Alquezar-Planas, D. P. Higgins, C. L. Singleton, and A. D. Greenwood Open
Koala retrovirus (KoRV) infection, endogenous in all northern koalas (Phascolarctos cinereus), has been found to occur at lower, but increasing, prevalence in the Kangaroo Island and Mount Lofty Ranges koala populations in South Australia.…
View article: Individuality and stability of the koala ( <i>Phascolarctos cinereus</i> ) faecal microbiota through time
Individuality and stability of the koala ( <i>Phascolarctos cinereus</i> ) faecal microbiota through time Open
Gut microbiota studies often rely on a single sample taken per individual, representing a snapshot in time. However, we know that gut microbiota composition in many animals exhibits intra-individual variation over the course of days to mon…
View article: Genome Reference Assembly for Bottlenecked Southern Australian Koalas
Genome Reference Assembly for Bottlenecked Southern Australian Koalas Open
Koala populations show marked differences in inbreeding levels and in the presence or absence of the endogenous Koala retrovirus (KoRV). These genetic differences among populations may lead to severe disease impacts threatening koala popul…
View article: Differential and defective transcription of koala retrovirus indicates the complexity of host and virus evolution
Differential and defective transcription of koala retrovirus indicates the complexity of host and virus evolution Open
Koala retrovirus (KoRV) is unique amongst endogenous (inherited) retroviruses in that its incorporation to the host genome is still active, providing an opportunity to study what drives this fundamental process in vertebrate genome evoluti…
View article: Individuality and stability of the koala (Phascolarctos cinereus) faecal microbiota through time
Individuality and stability of the koala (Phascolarctos cinereus) faecal microbiota through time Open
Background Gut microbiota studies often rely on a single sample taken per individual, representing a snapshot in time. However, we know that gut microbiota composition in many animals exhibits intra-individual variation over the course of …
View article: Health and Diseases of Koalas
Health and Diseases of Koalas Open
The koala (Phascolarctos cinereus) is an arboreal marsupial that is found throughout much of eastern and southeastern Australia, and it relies primarily on eucalypt trees for food, water and shelter [...]
View article: Differential and defective transcription of Koala Retrovirus indicate complexity of host and virus evolution
Differential and defective transcription of Koala Retrovirus indicate complexity of host and virus evolution Open
Supplementary Material for ‘Differential and defective transcription of Koala Retrovirus indicate complexity of host and virus evolution’, as published in Journal of General Virology.
View article: An Analysis of Demographic and Triage Assessment Findings in Bushfire-Affected Koalas (Phascolarctos cinereus) on Kangaroo Island, South Australia, 2019–2020
An Analysis of Demographic and Triage Assessment Findings in Bushfire-Affected Koalas (Phascolarctos cinereus) on Kangaroo Island, South Australia, 2019–2020 Open
In the 2019–2020 Australian bushfires, Kangaroo Island, South Australia, experienced catastrophic bushfires that burnt approximately half the island, with an estimated 80% of the koala population lost. During and after the event, rescued k…
View article: Molecular Diagnosis of Koala Retrovirus (KoRV) in South Australian Koalas (Phascolarctos cinereus)
Molecular Diagnosis of Koala Retrovirus (KoRV) in South Australian Koalas (Phascolarctos cinereus) Open
Koala retrovirus, a recent discovery in Australian koalas, is endogenised in 100% of northern koalas but has lower prevalence in southern populations, with lower proviral and viral loads, and an undetermined level of endogenisation. KoRV h…
View article: Identification and Prevalence of Phascolarctid Gammaherpesvirus Types 1 and 2 in South Australian Koala Populations
Identification and Prevalence of Phascolarctid Gammaherpesvirus Types 1 and 2 in South Australian Koala Populations Open
To determine Phascolarctid gammaherpesviruses (PhaHV) infection in South Australian koala populations, 80 oropharyngeal swabs from wild-caught and 87 oropharyngeal spleen samples and swabs from euthanased koalas were tested using two speci…
View article: Histological survey for oxalate nephrosis in Victorian koalas (<scp><i>Phascolarctos cinereus</i></scp>)
Histological survey for oxalate nephrosis in Victorian koalas (<span><i>Phascolarctos cinereus</i></span>) Open
The Mount Lofty Ranges koala ( Phascolarctos cinereus ) population in South Australia has a high prevalence of the renal disease oxalate nephrosis, for which an underlying genetic cause is suspected. South Australian koalas primarily origi…
View article: Periodontal disease in free‐ranging koalas (<i>Phascolarctos cinereus</i>) from the Mount Lofty Ranges, South Australia, and its association with koala retrovirus infection
Periodontal disease in free‐ranging koalas (<i>Phascolarctos cinereus</i>) from the Mount Lofty Ranges, South Australia, and its association with koala retrovirus infection Open
Background In northern Australian koala populations (Queensland and New South Wales), periodontal disease (gingivitis and periodontitis) is common while koala retrovirus subtype A is endogenous, with other subtypes transmitted exogenously.…
View article: Genetic diversity of Koala retrovirus env gene subtypes: insights into northern and southern koala populations
Genetic diversity of Koala retrovirus env gene subtypes: insights into northern and southern koala populations Open
Koala retrovirus (KoRV) is a recently endogenized retrovirus associated with neoplasia and immunosuppression in koala populations. The virus is known to display sequence variability and to be present at varying prevalence in different popu…
View article: Identification of stable reference genes for quantitative PCR in koalas
Identification of stable reference genes for quantitative PCR in koalas Open
To better understand host and immune response to diseases, gene expression studies require identification of reference genes with stable expression for accurate normalisation. This study describes the identification and testing of referenc…
View article: Differential and defective expression of Koala Retrovirus indicate complexity of host and virus evolution
Differential and defective expression of Koala Retrovirus indicate complexity of host and virus evolution Open
Koala retrovirus (KoRV) is unique amongst endogenous (inherited) retroviruses in that its incorporation to the host genome is still active, providing an opportunity to study what drives this fundamental process in vertebrate genome evoluti…
View article: Identification of stable reference genes for quantitative PCR in koalas
Identification of stable reference genes for quantitative PCR in koalas Open
To better understand host and immune response to diseases, gene expression studies require identification of reference genes with stable expression for accurate normalisation. This study describes the selection and testing of reference gen…