Natasha Vassileff
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View article: Inter-assay variability in the measurement of urinary C-terminal cross-linked telopeptide of type II collagen following anterior cruciate ligament reconstruction
Inter-assay variability in the measurement of urinary C-terminal cross-linked telopeptide of type II collagen following anterior cruciate ligament reconstruction Open
View article: Acute neuroinflammation promotes a metabolic shift that alters extracellular vesicle cargo in the mouse brain cortex
Acute neuroinflammation promotes a metabolic shift that alters extracellular vesicle cargo in the mouse brain cortex Open
Neuroinflammation is initiated through microglial activation and cytokine release which can be induced through lipopolysaccharide treatment (LPS) leading to a transcriptional cascade culminating in the differential expression of target pro…
View article: Microglial activation induces nitric oxide signalling and alters protein S‐nitrosylation patterns in extracellular vesicles
Microglial activation induces nitric oxide signalling and alters protein S‐nitrosylation patterns in extracellular vesicles Open
Neuroinflammation is an underlying feature of neurodegenerative conditions, often appearing early in the aetiology of a disease. Microglial activation, a prominent initiator of neuroinflammation, can be induced through lipopolysaccharide (…
View article: A Panel of miRNA Biomarkers Common to Serum and Brain-Derived Extracellular Vesicles Identified in Mouse Model of Amyotrophic Lateral Sclerosis
A Panel of miRNA Biomarkers Common to Serum and Brain-Derived Extracellular Vesicles Identified in Mouse Model of Amyotrophic Lateral Sclerosis Open
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease characterised by the deposition of aggregated proteins including TAR DNA-binding protein 43 (TDP-43) in vulnerable motor neurons and the brain. Extracellular vesicle…
View article: High resolution imaging and analysis of extracellular vesicles using mass spectral imaging and machine learning
High resolution imaging and analysis of extracellular vesicles using mass spectral imaging and machine learning Open
Extracellular vesicles (EVs) are potentially useful biomarkers for disease detection and monitoring. Development of a label‐free technique for imaging and distinguishing small volumes of EVs from different cell types and cell states would …
View article: Proteomic analysis of human serum Extracellular Vesicles reveals early diagnostic markers for Amyotrophic Lateral Sclerosis
Proteomic analysis of human serum Extracellular Vesicles reveals early diagnostic markers for Amyotrophic Lateral Sclerosis Open
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by the deposition of misfolded proteins leading to the death of motor neurons. Several ALS-associated proteins, including TAR DNA-binding protein 43 (TDP-43) …
View article: microRNA-146a modulates behavioural activity, neuroinflammation, and oxidative stress in adult mice
microRNA-146a modulates behavioural activity, neuroinflammation, and oxidative stress in adult mice Open
Small non-coding miRNA act as key regulators of several physiological processes due to their ability to interact with numerous target mRNA within a network. Whilst several miRNA can act in concert to regulate target mRNA expression, miR-14…
View article: Neuroinflammatory Modulation of Extracellular Vesicle Biogenesis and Cargo Loading
Neuroinflammatory Modulation of Extracellular Vesicle Biogenesis and Cargo Loading Open
View article: Inflammatory-Mediated Neuron-Glia Communication Modulates ALS Pathophysiology
Inflammatory-Mediated Neuron-Glia Communication Modulates ALS Pathophysiology Open
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease. It is characterized by the deposition of aggregated proteins and predominantly affects motor neurons and the motor cortex. Although ALS is a genetical…
View article: Revealing the Proteome of Motor Cortex Derived Extracellular Vesicles Isolated from Amyotrophic Lateral Sclerosis Human Postmortem Tissues
Revealing the Proteome of Motor Cortex Derived Extracellular Vesicles Isolated from Amyotrophic Lateral Sclerosis Human Postmortem Tissues Open
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by the deposition of misfolded proteins in the motor cortex and motor neurons. Although a multitude of ALS-associated mutated proteins have been identified, s…