Nate Levine
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View article: Platelet factor 4 (PF4) modulates endothelial cell antimicrobial activity to enhance bacterial clearance and improve sepsis outcomes
Platelet factor 4 (PF4) modulates endothelial cell antimicrobial activity to enhance bacterial clearance and improve sepsis outcomes Open
Introduction: Upon sensing pathogens, platelets (plt) release high concentrations of the positively charged chemokine PF4 from their ⍺-granules. PF4 rapidly binds to endothelial chemokine receptor, CXCR3B, and forms electrostatic interacti…
View article: Platelet factor 4 modulates endothelial cell antimicrobial activity to enhance bacterial clearance and improve sepsis outcomes
Platelet factor 4 modulates endothelial cell antimicrobial activity to enhance bacterial clearance and improve sepsis outcomes Open
Sepsis is a life-threatening condition characterized by dysregulated host responses to infection. Here, we identify platelet factor 4 (PF4) as a key mediator of vascular antimicrobial defense. In vitro, PF4 enhanced endothelial cell intern…
View article: Platelet Factor 4 Enhances Endothelial Cell Antimicrobial Activity <i>in Vitro</i> and Promotes Bacterial Clearance <i>In Vivo</i>, Improving Sepsis Outcomes
Platelet Factor 4 Enhances Endothelial Cell Antimicrobial Activity <i>in Vitro</i> and Promotes Bacterial Clearance <i>In Vivo</i>, Improving Sepsis Outcomes Open
Introduction: In this study, we investigated mechanism(s) by which the platelet-specific chemokine, platelet factor 4 (PF4), interacts with bacteria to enhance host-defense function and improve outcome in sepsis. Sepsis, a life-threatening…
View article: Platelet factor 4 limits neutrophil extracellular trap– and cell-free DNA–induced thrombogenicity and endothelial injury
Platelet factor 4 limits neutrophil extracellular trap– and cell-free DNA–induced thrombogenicity and endothelial injury Open
Plasma cell-free DNA (cfDNA), a marker of disease severity in sepsis, is a recognized driver of thromboinflammation and a potential therapeutic target. In sepsis, plasma cfDNA is mostly derived from neutrophil extracellular trap (NET) degr…
View article: A Novel Adenovirus (Adv)-Vaccinated Murine Model Simulates the Prothrombotic Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) Clinical Disorder
A Novel Adenovirus (Adv)-Vaccinated Murine Model Simulates the Prothrombotic Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) Clinical Disorder Open
Background: VITT has emerged as a rare (10 -5 to 10 -6 vaccinated individuals), but life-threatening side-effect of post-AdV-based COVID-19 vaccination, characterized by rapidly progressive catastrophic thrombosis, thrombocytopenia and hig…
Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury Open
Neutrophil extracellular traps (NETs) are abundant in sepsis, and proposed NET-directed therapies in sepsis prevent their formation or accelerate degradation. Yet NETs are important for microbial entrapment, as NET digestion liberates path…