Nathalie Cloutier
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View article: Development of a Patient-Reported Experience Measure Tool for Ambulatory Patients With Acute Unexpected Needs: The APEX Questionnaire
Development of a Patient-Reported Experience Measure Tool for Ambulatory Patients With Acute Unexpected Needs: The APEX Questionnaire Open
Background: The aim of this study was to develop a patient-reported experience measure (PREM) for comparing the experience of care received by ambulatory patients with acute unexpected needs presenting in emergency departments (EDs), walk-…
View article: Mot de la présidente de l’AIIUQ
Mot de la présidente de l’AIIUQ Open
View article: Un nouveau numéro et du nouveau dans l’équipe!
Un nouveau numéro et du nouveau dans l’équipe! Open
View article: L’AIIUQ : ce que nous sommes, ce que nous faisons et où nous allons
L’AIIUQ : ce que nous sommes, ce que nous faisons et où nous allons Open
View article: Mot de la présidente
Mot de la présidente Open
View article: Mot du comité éditorial de la revue Soins d’urgence
Mot du comité éditorial de la revue Soins d’urgence Open
View article: The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation
The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation Open
Secreted phospholipase A2-IIA (sPLA2-IIA) hydrolyzes phospholipids to liberate lysophospholipids and fatty acids. Given its poor activity toward eukaryotic cell membranes, its role in the generation of proinflammatory lipid mediators is un…
View article: 404 Platelets are a source of extracellular mitochondria and mitochondrial DNA in systemic lupus erythematosus
404 Platelets are a source of extracellular mitochondria and mitochondrial DNA in systemic lupus erythematosus Open
Background The accumulation of DNA and nuclear components in blood and their recognition by autoantibodies play a central role in the pathophysiology of systemic lupus erythematosus (SLE). Despite the efforts, the sources of these circulat…
View article: FcγRIIA expression accelerates nephritis and increases platelet activation in systemic lupus erythematosus
FcγRIIA expression accelerates nephritis and increases platelet activation in systemic lupus erythematosus Open
Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease characterized by deposits of immune complexes (ICs) in organs and tissues. The expression of FcγRIIA by human platelets, which is their unique receptor for immunoglob…
View article: Platelets Disseminate Extracellular Vesicles in Lymph in Rheumatoid Arthritis
Platelets Disseminate Extracellular Vesicles in Lymph in Rheumatoid Arthritis Open
Objective: The lymphatic system is a circulatory system that unidirectionally drains the interstitial tissue fluid back to blood circulation. Although lymph is utilized by leukocytes for immune surveillance, it remains inaccessible to plat…
View article: Optimiser l’accès aux soins de santé dans les services d’urgences pédiatriques : une voie d’accès rapide pour les enfants présentant un problème respiratoire aigu
Optimiser l’accès aux soins de santé dans les services d’urgences pédiatriques : une voie d’accès rapide pour les enfants présentant un problème respiratoire aigu Open
Introduction : La littérature démontre que la trajectoire de voie d’accès rapide (TVAR) est une modalité organisationnelle améliorant l’efficience des urgences, leur permettant de mieux répondre au défi de réorganisation imposé par la dema…
View article: Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations
Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations Open
Mitochondria are organelles that govern energy supply and control cell death. Mitochondria also express bacterial features, such as the presence of inner membrane cardiolipin and a circular genome rich in hypomethylated CpG motifs. While m…
View article: Differential attenuation of β2 integrin–dependent and –independent neutrophil migration by Ly6G ligation
Differential attenuation of β2 integrin–dependent and –independent neutrophil migration by Ly6G ligation Open
Antibody ligation of the murine neutrophil surface protein Ly6G disrupts neutrophil migration in some contexts but not others. We tested whether this variability reflected divergent dependence of neutrophil migration on β2 integrins, adhes…
View article: Optimiser l’accès aux soins de santé dans les services d’urgences pédiatriques : une voie d’accès rapide pour les enfants présentant un problème respiratoire aigu
Optimiser l’accès aux soins de santé dans les services d’urgences pédiatriques : une voie d’accès rapide pour les enfants présentant un problème respiratoire aigu Open
Introduction : La littérature démontre que la trajectoire de voie d’accès rapide (TVAR) est une modalité organisationnelle améliorant l’efficience des urgences, leur permettant de mieux répondre au défi de réorganisation imposé par la dema…
View article: Platelet abnormalities in Huntington’s disease
Platelet abnormalities in Huntington’s disease Open
Huntington’s disease (HD) is a hereditary disorder that typically manifests in adulthood with a combination of motor, cognitive and psychiatric problems. The pathology is caused by a mutation in the huntingtin gene which results in the pro…
View article: Portrait of blood-derived extracellular vesicles in patients with Parkinson’s disease
Portrait of blood-derived extracellular vesicles in patients with Parkinson’s disease Open
View article: Differential attenuation of β2 integrin-dependent and -independent neutrophil migration by Ly6G ligation
Differential attenuation of β2 integrin-dependent and -independent neutrophil migration by Ly6G ligation Open
Antibody ligation of the murine neutrophil surface protein Ly6G disrupts neutrophil migration in some contexts but not others. We tested whether this variability reflected divergent dependence of neutrophil migration on β2 integrins, adhes…
View article: AI-05 Platelet response to immune complexes
AI-05 Platelet response to immune complexes Open
Background There is a growing appreciation for the contribution of platelets to immunity; however, our knowledge mostly relies on platelet functions associated with vascular injury and the prevention of bleeding. Circulating immune complex…
View article: Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration
Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration Open
Significance Immune complexes (ICs) form when antibodies encounter their antigens. ICs are present in blood in multiple pathological conditions. Given the abundance of platelets in blood and that they express a receptor for ICs, called Fcγ…
View article: Presence of diabetes autoantigens in extracellular vesicles derived from human islets
Presence of diabetes autoantigens in extracellular vesicles derived from human islets Open
Beta-cell (β-cell) injury is the hallmark of autoimmune diabetes. However, the mechanisms by which autoreactive responses are generated in susceptible individuals are not well understood. Extracellular vesicles (EV) are produced by mammali…
View article: Revealing the diversity of extracellular vesicles using high-dimensional flow cytometry analyses
Revealing the diversity of extracellular vesicles using high-dimensional flow cytometry analyses Open
View article: II-11 Platelet activation and mitochondrial release in systemic lupus erythematosus
II-11 Platelet activation and mitochondrial release in systemic lupus erythematosus Open
Background Mitochondria are the powerhouses of the cell, providing energy to the cell through oxidative phosphorylation. Possibly owing to their similarities with bacteria, however, mitochondria extruded from cells promote inflammation. Pl…
View article: Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A <sub>2</sub> -IIA
Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A <sub>2</sub> -IIA Open
Significance On activation, blood platelets package components from their cytoplasm into microparticles (MPs), tiny vesicles released by cytoplasmic membrane budding and shedding. Given that MPs can impact other cellular lineages on intern…
View article: Detection and Quantification of Microparticles from Different Cellular Lineages Using Flow Cytometry. Evaluation of the Impact of Secreted Phospholipase A2 on Microparticle Assessment
Detection and Quantification of Microparticles from Different Cellular Lineages Using Flow Cytometry. Evaluation of the Impact of Secreted Phospholipase A2 on Microparticle Assessment Open
Microparticles, also called microvesicles, are submicron extracellular vesicles produced by plasma membrane budding and shedding recognized as key actors in numerous physio(patho)logical processes. Since they can be released by virtually a…