Nathalie Gault
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View article: Studying the Impact of European Union Regulatory Interventions for Minimising Risks From Medicines: Lessons Learnt and Recommendations
Studying the Impact of European Union Regulatory Interventions for Minimising Risks From Medicines: Lessons Learnt and Recommendations Open
Purpose The European Medicines Agency's (EMA) Pharmacovigilance Risk Assessment Committee (PRAC) launched a strategy to examine the public health impact of major regulatory interventions aimed at minimising risks of medicinal products. We …
View article: Use of the French National Health Data System (SNDS) in pharmacoepidemiology: A systematic review in its maturation phase
Use of the French National Health Data System (SNDS) in pharmacoepidemiology: A systematic review in its maturation phase Open
View article: Community-acquired Klebsiella pneumoniae pneumonia in ICU: a multicenter retrospective study
Community-acquired Klebsiella pneumoniae pneumonia in ICU: a multicenter retrospective study Open
View article: High Prevalence of NASH and Advanced Fibrosis in Type 2 Diabetes: A Prospective Study of 330 Outpatients Undergoing Liver Biopsies for Elevated ALT, Using a Low Threshold
High Prevalence of NASH and Advanced Fibrosis in Type 2 Diabetes: A Prospective Study of 330 Outpatients Undergoing Liver Biopsies for Elevated ALT, Using a Low Threshold Open
OBJECTIVE Most people with type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH) or advanced fibrosis remain undiagnosed, resulting in missed opportunities for early intervention. This multicenter prospective st…
View article: High Prevalence of NASH and Advanced Fibrosis in Type 2 Diabetes: A Prospective Study of 330 Outpatients Undergoing Liver Biopsies for Elevated ALT, Using a Low Threshold
High Prevalence of NASH and Advanced Fibrosis in Type 2 Diabetes: A Prospective Study of 330 Outpatients Undergoing Liver Biopsies for Elevated ALT, Using a Low Threshold Open
OBJECTIVE Most people with type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH) or advanced fibrosis (AF) remain undiagnosed, resulting in missed opportunities for early intervention. This multicenter, prospective study assessed …
View article: High Prevalence of NASH and Advanced Fibrosis in Type 2 Diabetes: A Prospective Study of 330 Outpatients Undergoing Liver Biopsies for Elevated ALT, Using a Low Threshold
High Prevalence of NASH and Advanced Fibrosis in Type 2 Diabetes: A Prospective Study of 330 Outpatients Undergoing Liver Biopsies for Elevated ALT, Using a Low Threshold Open
OBJECTIVE Most people with type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH) or advanced fibrosis remain undiagnosed, resulting in missed opportunities for early intervention. This multicenter prospective st…
View article: Relationship between clinical remission of perianal fistulas in Crohn’s disease and serum adalimumab concentrations: A multi-center cross-sectional study
Relationship between clinical remission of perianal fistulas in Crohn’s disease and serum adalimumab concentrations: A multi-center cross-sectional study Open
We found a significant association between high serum ADA concentrations and clinical remission of CD-associated perianal fistulas.
View article: Patient-important outcomes in lung transplantation: A systematic review
Patient-important outcomes in lung transplantation: A systematic review Open
View article: Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia
Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia Open
View article: Prospective external validation of a new non‐invasive test for the diagnosis of non‐alcoholic steatohepatitis in patients with type 2 diabetes
Prospective external validation of a new non‐invasive test for the diagnosis of non‐alcoholic steatohepatitis in patients with type 2 diabetes Open
Summary Background One of the unmet needs in patients with type 2 diabetes mellitus (T2DM) is the prediction of non‐alcoholic liver disease by non‐invasive blood tests, for each of the three main histological features, fibrosis, non‐alcoho…
View article: Prediction models of methicillin sensitive Staphylococcus aureus ventilator associated pneumonia relapse in trauma and brain injury patients: A retrospective analysis
Prediction models of methicillin sensitive Staphylococcus aureus ventilator associated pneumonia relapse in trauma and brain injury patients: A retrospective analysis Open
View article: Hepcidin and Iron Deficiency in Women One Year after Sleeve Gastrectomy: A Prospective Cohort Study
Hepcidin and Iron Deficiency in Women One Year after Sleeve Gastrectomy: A Prospective Cohort Study Open
Iron deficiency with or without anemia, needing continuous iron supplementation, is very common in obese patients, particularly those requiring bariatric surgery. The aim of this study was to address the impact of weight loss on the rescue…
View article: Renin-angiotensin system blockers and COVID-19
Renin-angiotensin system blockers and COVID-19 Open
View article: Les inhibiteurs du système rénine-angiotensine et la mortalité par COVID-19 : une cohorte prospective de 1160 patients hypertendus, et revue de littérature
Les inhibiteurs du système rénine-angiotensine et la mortalité par COVID-19 : une cohorte prospective de 1160 patients hypertendus, et revue de littérature Open
View article: Chronic use of renin‐angiotensin‐aldosterone system blockers and mortality in COVID‐19: A multicenter prospective cohort and literature review
Chronic use of renin‐angiotensin‐aldosterone system blockers and mortality in COVID‐19: A multicenter prospective cohort and literature review Open
Aims The role of renin‐angiotensin‐aldosterone system (RAAS) blockers on the course of coronavirus disease 2019 (COVID‐19) is debated. We assessed the association between chronic use of RAAS blockers and mortality among inpatients with COV…
View article: Sera Neutralizing Activities Against Severe Acute Respiratory Syndrome Coronavirus 2 and Multiple Variants 6 Months After Hospitalization for Coronavirus Disease 2019
Sera Neutralizing Activities Against Severe Acute Respiratory Syndrome Coronavirus 2 and Multiple Variants 6 Months After Hospitalization for Coronavirus Disease 2019 Open
Background Humoral response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurs within the first weeks after coronavirus disease 2019 (COVID-19). Those antibodies exert a neutralizing activity against SARS-CoV-2, whose e…
View article: Detection of SARS-CoV-2 N-antigen in blood during acute COVID-19 provides a sensitive new marker and new testing alternatives
Detection of SARS-CoV-2 N-antigen in blood during acute COVID-19 provides a sensitive new marker and new testing alternatives Open
View article: Impact on disease mortality of clinical, biological, and virological characteristics at hospital admission and overtime in COVID‐19 patients
Impact on disease mortality of clinical, biological, and virological characteristics at hospital admission and overtime in COVID‐19 patients Open
Little is known on the association between clinical factors and coronavirus disease 2019 (COVID‐19) more than 15 days after diagnosis. We conducted a multicentric prospective cohort of COVID‐19 hospitalized patients to describe clinical, b…
View article: PD-1/PD-L1 expression in anal squamous intraepithelial lesions
PD-1/PD-L1 expression in anal squamous intraepithelial lesions Open
Anal dysplastic lesions are accompanied by an inflammatory lymphocytic infiltrate expressing CD8 and PD-1, more frequent in high-grade lesions. These results highlight the involvement of the PD-1/PD-L1 pathway in the natural history of ana…
View article: Impact d’une organisation régionale coordonnée pour sécuriser la prise en charge des patients sous anticancéreux oraux : CHIMORAL, une étude comparative
Impact d’une organisation régionale coordonnée pour sécuriser la prise en charge des patients sous anticancéreux oraux : CHIMORAL, une étude comparative Open
View article: Effects of Long-term Norfloxacin Therapy in Patients With Advanced Cirrhosis
Effects of Long-term Norfloxacin Therapy in Patients With Advanced Cirrhosis Open
View article: Plans expérimentaux de type self-controlled en pharmacoépidémiologie
Plans expérimentaux de type self-controlled en pharmacoépidémiologie Open
Pharmacoepidemiology consists in the study of efficacy or safety of drugs in real life, with the use more and more frequently of medico-administrative databases. Study designs are generally observational, thus they are prone to confounding…
View article: Self-controlled designs in pharmacoepidemiology
Self-controlled designs in pharmacoepidemiology Open
Les études de pharmacoépidémiologie consistent à étudier l’effet de médicaments en vie réelle, et sont menées de plus en plus souvent sur bases de données médico-administratives. Ce sont principalement des études observationnelles, et sont…
View article: Self-controlled designs in pharmacoepidemiology involving electronic healthcare databases: a systematic review
Self-controlled designs in pharmacoepidemiology involving electronic healthcare databases: a systematic review Open
View article: Lack of clinical or haemodynamic rebound after abrupt interruption of beta‐blockers in patients with cirrhosis
Lack of clinical or haemodynamic rebound after abrupt interruption of beta‐blockers in patients with cirrhosis Open
Summary Background Beta‐blockers may have to be interrupted in patients with cirrhosis. The concept of a rebound after interruption of beta‐blockers is based on an animal study and on isolated case reports of variceal bleeding. Aim To dete…
View article: Long-term consequences of recurrent sports concussion
Long-term consequences of recurrent sports concussion Open