Nathalie Majeau
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View article: The polarity protein Yurt associates with the plasma membrane via basic and hydrophobic motifs embedded in its FERM domain
The polarity protein Yurt associates with the plasma membrane via basic and hydrophobic motifs embedded in its FERM domain Open
The subcellular distribution of the polarity protein Yurt (Yrt) is subjected to a spatio-temporal regulation in Drosophila melanogaster embryonic epithelia. After cellularization, Yrt binds to the lateral membrane of ectodermal cells and m…
View article: The polarity protein Yurt associates with the plasma membrane via basic and hydrophobic motifs embedded in its FERM domain
The polarity protein Yurt associates with the plasma membrane via basic and hydrophobic motifs embedded in its FERM domain Open
The subcellular distribution of the polarity protein Yrt is subjected to a spatio-temporal regulation in D. melanogaster embryonic epithelia. After cellularization, Yrt binds to the lateral membrane of ectodermal cells and maintains this l…
View article: Finding an Appropriate Mouse Model to Study the Impact of a Treatment for Friedreich Ataxia on the Behavioral Phenotype
Finding an Appropriate Mouse Model to Study the Impact of a Treatment for Friedreich Ataxia on the Behavioral Phenotype Open
Friedreich ataxia (FRDA) is a progressive neurodegenerative disease caused by a GAA repeat in the intron 1 of the frataxin gene (FXN) leading to a lower expression of the frataxin protein. The YG8sR mice are Knock-Out (KO) for their murine…
View article: Small-molecule inhibitors of proteasome increase CjCas9 protein stability
Small-molecule inhibitors of proteasome increase CjCas9 protein stability Open
The small size of CjCas9 can make easier its vectorization for in vivo gene therapy. However, compared to the SpCas9, the CjCas9 is, in general, less efficient to generate indels in target genes. The factors that affect its efficacity are …
View article: Identification of Abundant and Functional dodecaRNAs (doRNAs) Derived from Ribosomal RNA
Identification of Abundant and Functional dodecaRNAs (doRNAs) Derived from Ribosomal RNA Open
Using a modified RNA-sequencing (RNA-seq) approach, we discovered a new family of unusually short RNAs mapping to ribosomal RNA 5.8S, which we named dodecaRNAs (doRNAs), according to the number of core nucleotides (12 nt) their members con…