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View article: Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity
Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity Open
In chronic inflammatory disorders of the central nervous system (CNS), tissue-resident self-reactive T cells perpetuate disease. The specific tissue factors governing the persistence and continuous differentiation of these cells remain und…
View article: Arf6 regulates energy metabolism in neutrophils
Arf6 regulates energy metabolism in neutrophils Open
The small GTPase Arf6 regulates many cellular processes, including cytoskeletal remodeling, receptor endocytosis, and pathogen phagocytosis. Arf6 silencing in neutrophil (PMN)-like cells is well-known to inhibit chemotactic peptide-mediate…
View article: Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis
Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis Open
View article: Enhanced myelopoiesis and aggravated arthritis in S100a8-deficient mice
Enhanced myelopoiesis and aggravated arthritis in S100a8-deficient mice Open
Expressed strongly by myeloid cells, damage-associated molecular pattern (DAMP) proteins S100A8 and S100A9 are found in the serum of patients with infectious and autoimmune diseases. Compared to S100A9, the role of S100A8 is controversial.…
View article: The use of leukocytes’ secretome to individually target biological therapy in autoimmune arthritis: a case report
The use of leukocytes’ secretome to individually target biological therapy in autoimmune arthritis: a case report Open
Background Biological agents have allowed remarkable improvement in controlling autoimmune arthropathies, although none of the numerous biologics readily available represent a universal treatment standard. Moreover, classical and genetic p…
View article: S100A8/A9 and sRAGE kinetic after polytrauma; an explorative observational study
S100A8/A9 and sRAGE kinetic after polytrauma; an explorative observational study Open
View article: Discoidin domain receptor 1 promotes Th17 cell migration by activating the RhoA/ROCK/MAPK/ERK signaling pathway
Discoidin domain receptor 1 promotes Th17 cell migration by activating the RhoA/ROCK/MAPK/ERK signaling pathway Open
Effector T cell migration through the tissue extracellular matrix (ECM) is an important step of the adaptive immune response and in the development of inflammatory diseases. However, the mechanisms involved in this process are still poorly…
View article: Regulation of TLR3 Activation by S100A9
Regulation of TLR3 Activation by S100A9 Open
Recognition of viral dsRNA by endosomal TLR3 activates innate immune response during virus infection. Trafficking of TLR3 to the endolysosomal compartment arising from fusion of late endosome (LE) with lysosome is required for recognition …
View article: Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux
Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux Open
S100A8/A9 (calprotectin) and S100A12 proinflammatory mediators are found at inflammatory sites and in the serum of patients with inflammatory or autoimmune diseases. These cytoplasmic proteins are secreted by neutrophils at sites of inflam…