Nathan K. Archer
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View article: RNase L represses hair follicle regeneration through altered innate immune signaling
RNase L represses hair follicle regeneration through altered innate immune signaling Open
Mammalian injury responses are predominantly characterized by fibrosis and scarring rather than functional regeneration. This limited regenerative capacity in mammals could reflect a loss of proregeneration programs or active suppression b…
View article: <i>Staphylococcus aureus</i> Proteases: Orchestrators of Skin Inflammation
<i>Staphylococcus aureus</i> Proteases: Orchestrators of Skin Inflammation Open
Skin homeostasis relies on a delicate balance between host proteases and protease inhibitors along with those secreted from microbial communities, as disruption to this harmony contributes to the pathogenesis of inflammatory skin disorders…
View article: Dry and liquid formulations of IBT-V02, a novel multi-component toxoid vaccine, are effective against Staphylococcus aureus isolates from low-to-middle income countries
Dry and liquid formulations of IBT-V02, a novel multi-component toxoid vaccine, are effective against Staphylococcus aureus isolates from low-to-middle income countries Open
Staphylococcus aureus is the leading cause of skin and soft tissue infections (SSTIs) in the U.S. as well as more serious invasive diseases, including bacteremia, sepsis, endocarditis, surgical site infections, osteomyelitis, and pneumonia…
View article: Bactericidal Efficacy of the Combination of Maresin-like Proresolving Mediators and Carbenicillin Action on Biofilm-Forming Burn Trauma Infection-Related Bacteria
Bactericidal Efficacy of the Combination of Maresin-like Proresolving Mediators and Carbenicillin Action on Biofilm-Forming Burn Trauma Infection-Related Bacteria Open
Biofilm-associated bacterial infections are the major reason for treatment failure in many diseases including burn trauma infections. Uncontrolled inflammation induced by bacteria leads to materiality, tissue damage, and chronic diseases. …
View article: <i>Staphylococcus aureus</i> proteases trigger eosinophil-mediated skin inflammation
<i>Staphylococcus aureus</i> proteases trigger eosinophil-mediated skin inflammation Open
Staphylococcus aureus skin colonization and eosinophil infiltration are associated with many inflammatory skin disorders, including atopic dermatitis, bullous pemphigoid, Netherton’s syndrome, and prurigo nodularis. However, whether there …
View article: Bactericidal Efficacy of the Combination of Maresin-like Pro-resolving Mediators and Carbenicillin Action on Biofilm-Forming Burn-Trauma Infection Related Bacteria
Bactericidal Efficacy of the Combination of Maresin-like Pro-resolving Mediators and Carbenicillin Action on Biofilm-Forming Burn-Trauma Infection Related Bacteria Open
Biofilm-associated bacterial infections are the major reason for treatment failure in many diseases including burn trauma infections. Uncontrolled inflammation induced by bacteria leads to materiality, tissue damage and chronic diseases. S…
View article: The 2023 Orthopaedic Research Society's International Consensus Meeting on musculoskeletal infection: Summary from the host immunity section
The 2023 Orthopaedic Research Society's International Consensus Meeting on musculoskeletal infection: Summary from the host immunity section Open
Musculoskeletal infections (MSKI), which are a major problem in orthopedics, occur when the pathogen eludes or overwhelms the host immune system. While effective vaccines and immunotherapies to prevent and treat MSKI should be possible, fu…
View article: γδ T cell-intrinsic IL-1R promotes survival during Staphylococcus aureus bacteremia
γδ T cell-intrinsic IL-1R promotes survival during Staphylococcus aureus bacteremia Open
Staphylococcus aureus is a leading cause of bacteremia, further complicated by the emergence of antibiotic-resistant strains such as methicillin-resistant S. aureus (MRSA). A better understanding of host defense mechanisms is needed for th…
View article: Neutrophil-intrinsic TNF receptor signaling orchestrates host defense against <i>Staphylococcus aureus</i>
Neutrophil-intrinsic TNF receptor signaling orchestrates host defense against <i>Staphylococcus aureus</i> Open
Staphylococcus aureus is the leading cause of skin and soft tissue infections and is a major health burden due to the emergence of antibiotic-resistant strains. To address the unmet need of alternative treatments to antibiotics, a better u…
View article: TNF receptors orchestrate differential neutrophil responses critical to immunity against <i>Staphylococcus aureus</i> skin infection
TNF receptors orchestrate differential neutrophil responses critical to immunity against <i>Staphylococcus aureus</i> skin infection Open
As the leading cause of skin and soft tissue infections, Staphylococcus aureus is a major health burden and a continued threat to human health due to the emergence of antibiotic-resistance. Through this current study, we aimed to better ch…
View article: <i>Plasmodium</i>-infected mosquito bite elicits an immune response at the bite site
<i>Plasmodium</i>-infected mosquito bite elicits an immune response at the bite site Open
To induce long-lasting immunity, the host’s immune system must recognize and respond to an invading pathogen upon first encounter. Plasmodium sporozoites, the infective stage of the malaria parasite, are inoculated into the skin by infecte…
View article: Epicutaneous <i>Staphylococcus aureus</i> exposure triggers lung inflammation via epithelia-intrinsic IL-36R signaling
Epicutaneous <i>Staphylococcus aureus</i> exposure triggers lung inflammation via epithelia-intrinsic IL-36R signaling Open
Allergic diseases have been increasing recently and affect nearly 20% of the human population, including 200 million people with atopic dermatitis (AD), 250 million people with food allergies, and 600 million people with allergic rhinitis …
View article: Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1α signaling and glutamine metabolism
Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1α signaling and glutamine metabolism Open
Tissue injury induces metabolic changes in stem cells, which likely modulate regeneration. Using a model of organ regeneration called wound-induced hair follicle neogenesis (WIHN), we identified skin-resident bacteria as key modulators of …
View article: Staphylococcus aureus adaptive evolution: Recent insights on how immune evasion, immunometabolic subversion and host genetics impact vaccine development
Staphylococcus aureus adaptive evolution: Recent insights on how immune evasion, immunometabolic subversion and host genetics impact vaccine development Open
Despite meritorious attempts, a S. aureus vaccine that prevents infection or mitigates severity has not yet achieved efficacy endpoints in prospective, randomized clinical trials. This experience underscores the complexity of host- S. aure…
View article: Crisaborole efficacy in murine models of skin inflammation and <scp><i>Staphylococcus aureus</i></scp> infection
Crisaborole efficacy in murine models of skin inflammation and <span><i>Staphylococcus aureus</i></span> infection Open
Phosphodiesterase 4 (PDE4) is highly expressed in keratinocytes and immune cells and promotes pro‐inflammatory responses upon activation. The activity of PDE4 has been attributed to various inflammatory conditions, leading to the developme…
View article: 983. Pathogen-specific PET/CT imaging for Gram negative implant-associated spinal infections
983. Pathogen-specific PET/CT imaging for Gram negative implant-associated spinal infections Open
Background Rapid and accurate diagnosis of bacterial implant-associated spinal infection is essential for early intervention, surgical planning and rational use of antibiotics. While this infection is predominantly caused by Gram positive …
View article: The Novel Oxazolidinone TBI-223 Is Effective in Three Preclinical Mouse Models of Methicillin-Resistant Staphylococcus aureus Infection
The Novel Oxazolidinone TBI-223 Is Effective in Three Preclinical Mouse Models of Methicillin-Resistant Staphylococcus aureus Infection Open
Staphylococcus aureus is the predominant cause of bloodstream, skin, and bone infections in humans. Resistance to commonly used antibiotics is a growing concern, making it more difficult to treat staphylococcal infections.
View article: Release of the pre-assembled naRNA-LL37 composite DAMP re-defines neutrophil extracellular traps (NETs) as intentional DAMP webs
Release of the pre-assembled naRNA-LL37 composite DAMP re-defines neutrophil extracellular traps (NETs) as intentional DAMP webs Open
Neutrophil extracellular traps (NETs) are a key antimicrobial feature of cellular innate immunity mediated by polymorphonuclear neutrophils (PMNs), the primary human leukocyte population. NETs trap and kill microbes but have also been link…
View article: Dendritic cell immunoreceptor drives atopic dermatitis by modulating oxidized CaMKII-involved mast cell activation
Dendritic cell immunoreceptor drives atopic dermatitis by modulating oxidized CaMKII-involved mast cell activation Open
Allergens have been identified as potential triggers in patients with atopic dermatitis (AD). Patients with AD are highly sensitive to cockroach allergen. The underlying mechanism, however, remains undetermined. Here, we established a cock…
View article: Dynamic PET-facilitated modeling and high-dose rifampin regimens for <i>Staphylococcus aureus</i> orthopedic implant–associated infections
Dynamic PET-facilitated modeling and high-dose rifampin regimens for <i>Staphylococcus aureus</i> orthopedic implant–associated infections Open
Current rifampin dosing achieves subtherapeutic concentrations within S. aureus –infected bone, which can be overcome with higher rifampin dosing.
View article: 125. Dynamic PET facilitated Pharmacokinetic Modeling and High-dose Rifampin Regimens for <i>Staphylococcus aureus</i> Orthopedic Implant Associated Infections: Bench to Bedside
125. Dynamic PET facilitated Pharmacokinetic Modeling and High-dose Rifampin Regimens for <i>Staphylococcus aureus</i> Orthopedic Implant Associated Infections: Bench to Bedside Open
Background Rifampin, has potent, dose-dependent sterilizing activity against Gram-positive bacteria with the area under the concentration-time curve (AUC) being the most predictive of bactericidal activity. Combination therapy with rifampi…