Nathan Cramer
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View article: Lasting Increases in Neuronal Activity and Serotonergic Receptor Expression Following Gestational Chlorpyrifos Exposure
Lasting Increases in Neuronal Activity and Serotonergic Receptor Expression Following Gestational Chlorpyrifos Exposure Open
Perinatal exposure to the organophosphorus insecticide chlorpyrifos (CPF) is associated with an increased incidence of neurodevelopmental disorders, such as autism spectrum disorder. While these behavioral detriments have been modeled in r…
View article: Nicotinic Modulation of Fast-Spiking Neurons in Rat Somatosensory Cortex across Development
Nicotinic Modulation of Fast-Spiking Neurons in Rat Somatosensory Cortex across Development Open
Signaling at nicotinic acetylcholine receptors (nAChRs) is vital for normal development of cerebral cortical circuits. These developing circuits are also shaped by fast-spiking (FS) inhibitory cortical neurons. While nicotinic dysfunction …
View article: Nicotinic Modulation of Fast-spiking Neurons in Rat Somatosensory Cortex Across Development
Nicotinic Modulation of Fast-spiking Neurons in Rat Somatosensory Cortex Across Development Open
Signaling at nicotinic acetylcholine receptors (nAChRs) is vital for normal development of cerebral cortical circuits. These developing circuits are also shaped by fast-spiking (FS) inhibitory cortical neurons. While nicotinic dysfunction …
View article: Lasting Increases in Neuronal Activity and Serotonergic Receptor Expression Following Gestational Chlorpyrifos Exposure
Lasting Increases in Neuronal Activity and Serotonergic Receptor Expression Following Gestational Chlorpyrifos Exposure Open
Perinatal exposure to the organophosphorus insecticide chlorpyrifos (CPF) is associated with an increased incidence of neurodevelopmental disorders, such as autism spectrum disorder. While these behavioral detriments have been modeled in r…
View article: Gestational Chlorpyrifos Exposure Imparts Lasting Alterations to the Rat Somatosensory Cortex
Gestational Chlorpyrifos Exposure Imparts Lasting Alterations to the Rat Somatosensory Cortex Open
Chlorpyrifos is an organophosphorus pesticide used extensively in agricultural and residential settings for nearly 60 years. Gestational, sub-acute exposure to chlorpyrifos is linked to increased prevalence of neurodevelopmental disorders.…
View article: Sex differences in central amygdala glutamate responses to calcitonin gene-related peptide
Sex differences in central amygdala glutamate responses to calcitonin gene-related peptide Open
Women are disproportionately affected by chronic pain compared to men. While societal and environmental factors contribute to this disparity, sex-based biological differences in the processing of pain are also believed to play significant …
View article: The role of microglia in neuronal and cognitive function during high altitude acclimatization
The role of microglia in neuronal and cognitive function during high altitude acclimatization Open
Due to their interactions with the neurovasculature, microglia are implicated in maladaptive responses to hypobaric hypoxia at high altitude (HA). To explore these interactions at HA, pharmacological depletion of microglia with the colony-…
View article: Divergent Changes in PBN Excitability in a Mouse Model of Neuropathic Pain
Divergent Changes in PBN Excitability in a Mouse Model of Neuropathic Pain Open
The transition from acute to chronic pain involves maladaptive plasticity in central nociceptive pathways. Growing evidence suggests that changes within the parabrachial nucleus (PBN), an important component of the spino–parabrachio–amygda…
View article: Elevated Serotonin in Mouse Spinal Dorsal Horn Is Pronociceptive
Elevated Serotonin in Mouse Spinal Dorsal Horn Is Pronociceptive Open
Serotonergic neurons in the rostral ventral medulla (RVM) contribute to bidirectional control of pain through modulation of spinal and trigeminal nociceptive networks. Deficits in this pathway are believed to contribute to pathologic pain …
View article: Divergent changes in PBN excitability in a mouse model of neuropathic pain
Divergent changes in PBN excitability in a mouse model of neuropathic pain Open
The transition from acute to chronic pain involves maladaptive plasticity in central nociceptive pathways. Growing evidence suggests that changes within the parabrachial nucleus (PBN), an important component of the spino–parabrachio–amygda…
View article: Elevated serotonin in mouse spinal dorsal horn is pronociceptive
Elevated serotonin in mouse spinal dorsal horn is pronociceptive Open
Serotonergic neurons in the rostral ventral medulla (RVM) contribute to bidirectional control of pain through modulation of spinal and trigeminal nociceptive networks. Deficits in this pathway are believed to contribute to pathological pai…
View article: Parabrachial Nucleus Activity in Nociception and Pain in Awake Mice
Parabrachial Nucleus Activity in Nociception and Pain in Awake Mice Open
The parabrachial nuclear complex (PBN) is a nexus for aversion and for the sensory and affective components of pain perception. We have previously shown that during chronic pain PBN neurons in anesthetized rodents have amplified activity. …
View article: Review of: "Depolarization block of interneurons"
Review of: "Depolarization block of interneurons" Open
Potential competing interests: No potential competing interests to
View article: Noradrenergic Input from Nucleus of the Solitary Tract Regulates Parabrachial Activity in Mice
Noradrenergic Input from Nucleus of the Solitary Tract Regulates Parabrachial Activity in Mice Open
The parabrachial complex (PB) is critically involved in aversive processes, and chronic pain is associated with amplified activity of PB neurons in rodent models of neuropathic pain. Here, we demonstrate that catecholaminergic input from t…
View article: Parabrachial nucleus activity in nociception and pain in awake mice
Parabrachial nucleus activity in nociception and pain in awake mice Open
The parabrachial nuclear complex (PBN) is a nexus for aversion, and for the sensory and affective components of pain perception. We have previously shown that, during chronic pain, PBN neurons in anesthetized rodents have amplified activit…
View article: Molecular, Circuit, and Stress Response Characterization of Ventral Pallidum Npas1-Neurons
Molecular, Circuit, and Stress Response Characterization of Ventral Pallidum Npas1-Neurons Open
Altered activity of the ventral pallidum (VP) underlies disrupted motivation in stress and drug exposure. The VP is a very heterogeneous structure composed of many neuron types with distinct physiological properties and projections. Neuron…
View article: Noradrenergic input from nucleus of the solitary tract regulates parabrachial activity in mice
Noradrenergic input from nucleus of the solitary tract regulates parabrachial activity in mice Open
The parabrachial complex (PB) is critically involved in aversive processes, and chronic pain is associated with amplified activity of PB neurons in rodent models of neuropathic pain. Here we demonstrate that catecholaminergic input from th…
View article: Medullary kappa-opioid receptor neurons inhibit pain and itch through a descending circuit
Medullary kappa-opioid receptor neurons inhibit pain and itch through a descending circuit Open
In perilous and stressful situations, the ability to suppress pain can be critical for survival. The rostral ventromedial medulla contains neurons that robustly inhibit nocioception at the level of the spinal cord through a top-down modula…
View article: Medullary kappa-opioid receptor neurons inhibit pain and itch through a descending circuit
Medullary kappa-opioid receptor neurons inhibit pain and itch through a descending circuit Open
In perilous and stressful situations, the ability to suppress pain can be critical for survival. The rostral ventromedial medulla (RVM) contains neurons that robustly inhibit nociception at the level of the spinal cord through a top-down m…
View article: Perinatal Fentanyl Exposure Leads to Long-Lasting Impairments in Somatosensory Circuit Function and Behavior
Perinatal Fentanyl Exposure Leads to Long-Lasting Impairments in Somatosensory Circuit Function and Behavior Open
One consequence of the opioid epidemic are lasting neurodevelopmental sequelae afflicting adolescents exposed to opioids in the womb. A translationally relevant and developmentally accurate preclinical model is needed to understand the beh…
View article: Divergent profiles of fentanyl withdrawal and associated pain in mice and rats
Divergent profiles of fentanyl withdrawal and associated pain in mice and rats Open
Opioid abuse has devastating effects on patients, their families, and society. Withdrawal symptoms are severely unpleasant, prolonged, and frequently hinder recovery or lead to relapse. The sharp increase in abuse and overdoses arising fro…
View article: Control of synaptic transmission and neuronal excitability in the parabrachial nucleus
Control of synaptic transmission and neuronal excitability in the parabrachial nucleus Open
The parabrachial nucleus (PB) is a hub for aversive behaviors, including those related to pain. We have shown that the expression of chronic pain is causally related to amplified activity of PB neurons, and to changes in synaptic inhibitio…
View article: Perinatal fentanyl exposure leads to long-lasting impairments in somatosensory circuit function and behavior
Perinatal fentanyl exposure leads to long-lasting impairments in somatosensory circuit function and behavior Open
One consequence of the opioid epidemic are lasting neurodevelopmental sequelae afflicting adolescents exposed to opioids in the womb. A translationally relevant and developmentally accurate preclinical model is needed to understand the beh…
View article: An Amygdalo-Parabrachial Pathway Regulates Pain Perception and Chronic Pain
An Amygdalo-Parabrachial Pathway Regulates Pain Perception and Chronic Pain Open
The parabrachial (PB) complex mediates both ascending nociceptive signaling and descending pain modulatory information in the affective/emotional pain pathway. We have recently reported that chronic pain is associated with amplified activi…
View article: An amygdalo-parabrachial pathway regulates pain perception and chronic pain
An amygdalo-parabrachial pathway regulates pain perception and chronic pain Open
The parabrachial (PB) complex mediates both ascending nociceptive signaling and descending pain modulatory information in the affective/emotional pain pathway. We have recently reported that chronic pain is associated with amplified activi…
View article: Neuronal and vascular deficits following chronic adaptation to high altitude
Neuronal and vascular deficits following chronic adaptation to high altitude Open
We sought to understand the mechanisms underlying cognitive deficits that are reported to affect non-native subjects following their prolonged stay and/or work at high altitude (HA). We found that mice exposed to a simulated environment of…
View article: Experimental Traumatic Brain Injury Identifies Distinct Early and Late Phase Axonal Conduction Deficits of White Matter Pathophysiology, and Reveals Intervening Recovery
Experimental Traumatic Brain Injury Identifies Distinct Early and Late Phase Axonal Conduction Deficits of White Matter Pathophysiology, and Reveals Intervening Recovery Open
Traumatic brain injury (TBI) patients often exhibit slowed information processing speed that can underlie diverse symptoms. Processing speed depends on neural circuit function at synapses, in the soma, and along axons. Long axons in white …