Nathan Cuka
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View article: Correlation of the Effective Residual Vital (HPC) Dose with Engraftment Kinetics in Autologous Transplantation Amongst Myeloma and Lymphoma Patients
Correlation of the Effective Residual Vital (HPC) Dose with Engraftment Kinetics in Autologous Transplantation Amongst Myeloma and Lymphoma Patients Open
IntroductionIn clinical practice, a hematopoietic progenitor cell (HPC) dose of 2 million CD34+ cells/kg is the desired minimum needed for timely neutrophil and platelet (PLT) engraftment in autologous hematopoietic cell transplantation (H…
View article: Extra-abdominal umbilical vein varix in a newborn
Extra-abdominal umbilical vein varix in a newborn Open
Umbilical vein varices are rare fetal anomalies typically found intra-abdominally and identified on ultrasound prior to birth. Intra-abdominal umbilical vein varices account for approximately 4% of umbilical cord abnormalities and are thou…
View article: Expanding the Spectrum of EBV-positive Marginal Zone Lymphomas
Expanding the Spectrum of EBV-positive Marginal Zone Lymphomas Open
Traditionally low-grade B-cell lymphomas have been excluded from the category of monomorphic posttransplant lymphoproliferative disorders. However, recent reports identified Epstein-Barr virus-positive (EBV + ) extranodal marginal zone lym…
View article: Development of paroxysmal nocturnal hemoglobinuria in CALR-positive myeloproliferative neoplasm
Development of paroxysmal nocturnal hemoglobinuria in CALR-positive myeloproliferative neoplasm Open
Yarden S Fraiman,1,2 Nathan Cuka,3 Denise Batista,3 Milena Vuica-Ross,3 Alison R Moliterno4 1Department of Pediatrics, Harvard Medical School, 2Department of Pediatrics, Boston University School of Medicine, Boston, MA, 3Department of Path…
View article: Development of paroxysmal nocturnal hemoglobinuria in CALR-positive myeloproliferative neoplasm
Development of paroxysmal nocturnal hemoglobinuria in CALR-positive myeloproliferative neoplasm Open
Paroxysmal nocturnal hemoglobinuria (PNH), a disease characterized by intravascular hemolysis, thrombosis, and bone marrow failure, is associated with mutations in the PIG-A gene, resulting in a deficiency of glycosylphosphatidylinositol-a…
View article: Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma
Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma Open
Objective Recent data supports a significant role for immune checkpoint inhibitors in the treatment of solid tumours. Here, we evaluate gastric and gastro-oesophageal junction (G/GEJ) adenocarcinomas for their expression of programmed deat…
View article: Aberrant NHERF1 expression as a biomarker in lung carcinoma
Aberrant NHERF1 expression as a biomarker in lung carcinoma Open
PDZ domains and an ezrin-radixin-moesin (ERM) binding region.Through these sites, NHERF1interacts with a variety of growth factors and regulatory proteins including EGFR and PDGFR (PDZ domains) and F-actin(ERM region) [4][5][6][7][8][9].Re…
View article: PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency Open
This study showed that mismatch-repair status predicted clinical benefit of immune checkpoint blockade with pembrolizumab. (Funded by Johns Hopkins University and others; ClinicalTrials.gov number, NCT01876511.).