Explanipedia

Opportunistic AI-derived adiposity measures from coronary artery calcium scans predict new-onset type 2 diabetes in adults without obesity or hyperglycemia: insights from the AI-CVD study within MESA Open

Morteza Naghavi, Amir Vahedian‐Azimi, Kyle Atlas, Anthony P. Reeves, Chen‐Yu Zhang , et al. · 2025

The impact of electronic health messaging on diagnosis of familial hypercholesterolemia and management of patients with LDL-C ≥190 mg/dL Open

Yihang Fan, Lingling Li, WENJUN FAN, Jing Gu, Robert J. Sanchez , et al. · 2025

BPA alerts for patients with LDL-C ≥ 190 mg/dL improve diagnosis rates for hyperlipidemia and FH, increase LLT use, and reduce LDL-C levels.

Joint Consideration of LDL-C and Polygenic Risk for Coronary Heart Disease Risk Assessment Open

Carlos Iribarren, Meng Lü, Roberto Elosúa, Martha Gulati, Nathan D. Wong , et al. · 2025

Lipoprotein(a), family history, and incidence of premature ASCVD events in a pooled US cohort Open

Yihang Fan, Wenjun Fan, Xingdi Hu, Michael Y. Tsai, Ron C. Hoogeveen , et al. · 2025

Elevated Lp(a) is an important predictor of both premature and later onset ASCVD events.

Editors’ message – September 2025 Open

Nathan D. Wong, Erin D Michos · 2025

US POPULATION ELIGIBILITY AND ESTIMATED PREVENTABLE CARDIOVASCULAR DISEASE EVENTS FROM INCLISIRAN TREATMENT Open

Nathan D. Wong, Hridhay Karthikeyan, WENJUN FAN, Batul Electricwala · 2025

US eligibility and preventable cardiovascular disease events from semaglutide in type 2 diabetes Open

Hridhay Karthikeyan, Wenjun Fan, Nathan D. Wong · 2025

Background The SUSTAIN-6 trial showed the cardiovascular disease (CVD) benefits of semaglutide among patients with type 2 diabetes mellitus (T2DM). We estimated the US population eligibility and preventable CVD events from semaglutide. Met…

LDL-C AND POLYGENIC RISK FOR CORONARY HEART DISEASE RISK ASSESSMENT Open

Jamal S. Rana, Meng Lü, Roberto Elosúa, Martha Gulati, Nathan D. Wong , et al. · 2025

Health outcomes and survival among patients with severe hypertriglyceridemia after acute pancreatitis Open

Michael S. Broder, Eunice Chang, Kathleen F. Villa, Nathan D. Wong · 2025

ED visits, hospitalizations, and mortality were more common in patients with sHTG-AP than sHTG without AP, warranting better prevention of initial episodes. Prospective studies are also needed to establish causal links between AP and clini…

The HEALERS: a patient, community, and stakeholder advisory board focus group series to refine a novel virtual world-based cardiac rehabilitation intervention and clinical trial Open

Helayna Abraham, Grace Patrice Anyetei-Anum, Ashton Krogman, Donald Clark, Melvin Echols , et al. · 2025

Background Cardiac rehabilitation (CR) is a widely underutilized secondary cardiovascular disease prevention strategy, due to a variety of barriers to participation that disproportionately impact women, minoritized racial and ethnic groups…

Editors’ message – June 2025 Open

Erin D Michos, Nathan D. Wong · 2025

U.S. Eligibility and Preventable Cardiovascular, Diabetes, and Kidney Outcomes From Semaglutide in the SELECT Trial Open

Hongmei Yan, Hridhay Karthikeyan, Wenjun Fan, Qin Yang, Nathan D. Wong · 2025

Cross-Sectional analysis of demographic and clinical characteristics of patients in the United States using icosapent ethyl Open

Peter P. Tóth, John Nelson, Handrean Soran, Om P. Ganda, Nathan D. Wong , et al. · 2025

Introduction Icosapent ethyl (IPE) is indicated for the treatment of severe hypertriglyceridemia (triglycerides ≥500 mg/dl) and for reducing the risk of cardiovascular (CV) events in statin-treated adults with moderately elevated triglycer…

Editors’ Message – March 2025 Open

Nathan D. Wong, Erin D Michos · 2025

Atherosclerotic Cardiovascular Disease Risk Prediction Models in China, Japan, and Korea Open

Patricia K. Nguyen, Dong Zhao, Tomonori Okamura, Hyeon Chang Kim, Nathan D. Wong , et al. · 2025

The management of atherosclerotic cardiovascular disease (ASCVD) in the United States is currently based upon large epidemiological studies in primarily non-Hispanic White subjects. Although this strategy provides a uniform approach that i…

Composite cardiovascular risk factor control in US adults with diabetes and relation to social determinants of health: The All of Us research program Open

Frances Golden, Johnathan Tran, Nathan D. Wong · 2025

Lipoprotein(a) and cardiovascular disease: Evidence, recommendations and emerging therapies Open

Nathan D. Wong · 2025

Lipoprotein(a) (Lp[a]) is a low-density lipoprotein (LDL) like particle which has atherogenic, proinflammatory and prothrombotic properties. Elevated in approximately 1 in 5 persons, increased levels of Lp(a) have been shown by epidemiolog…

United States Pooled Cohort Cardiovascular Disease Risk Scores in Adults With Diabetes Mellitus Open

Yanglu Zhao, Ralph B. D’Agostino, Shaista Malik, Karol E. Watson, Alain G. Bertoni , et al. · 2024

Editors’ message – December 2024 Open

Erin D Michos, Nathan D. Wong · 2024

Interplay between lifestyle factors and polygenic risk for incident coronary heart disease in a large multiethnic cohort Open

Carlos Iribarren, Meng Lü, Martha Gulati, Nathan D. Wong, Roberto Elosúa , et al. · 2024

Artificial intelligence applied to coronary artery calcium scans (AI-CAC) significantly improves cardiovascular events prediction Open

Morteza Naghavi, Anthony P. Reeves, K. Atlas, Chenyu Zhang, Thomas Atlas , et al. · 2024

Coronary artery calcium (CAC) scans contain valuable information beyond the Agatston Score which is currently reported for predicting coronary heart disease (CHD) only. We examined whether new artificial intelligence (AI) applied to CAC sc…

AI-Enabled CT Cardiac Chamber Volumetry Predicts Atrial Fibrillation and Stroke Comparable to MRI Open

Morteza Naghavi, Anthony P. Reeves, Kyle Atlas, Chenyu Zhang, Dong Li , et al. · 2024

Longitudinal Changes in Lifestyle Behaviors and Cardiovascular Health During the Transition to Fatherhood: The Dad Bod Study Rationale and Design Open

Matthew J. Landry, J PINEDA, Jaylen M Lee, Michael A. Hoyt, Karen L. Edwards , et al. · 2024

Background Despite the importance of the transition to fatherhood as a critical life stage among young adult men, much remains unknown about the factors predictive of ideal cardiovascular health (CVH) and how CVH is impacted as young men f…

Coronary Artery Calcium Staging to Guide Preventive Interventions Open

David J. Maron, Matthew J. Budoff, Joseph C Sky, William J. Bommer, Sarah D Epstein , et al. · 2024

Liver fibrosis according to diabetes status and relation to cardiovascular risk and mortality in US adults Open

Matthew Bang, Wenjun Fan, Nathan D. Wong · 2024

Our findings indicate the need for increased efforts to identify those at risk of liver fibrosis in adults with pre-DM or DM to prevent CVD and total mortality.

Editors’ Message – September 2024 Open

Nathan D. Wong, Erin D Michos · 2024

Coronary Artery Calcium for Risk Stratification Among Persons With Very High HDL Cholesterol Open

Alexander C. Razavi, Anurag Mehta, Nathan D. Wong, Alan Rozanski, Matthew J. Budoff , et al. · 2024

Energy Intake and Dietary Glycemic Load in Late Morning and Risk of Type 2 Diabetes: the Hispanic Community Health Study/Study of Latinos, a Multicenter Prospective Cohort Study Open

Jin Dai, Roch A. Nianogo, Nathan D. Wong, Tannaz Moin, Amanda C. McClain , et al. · 2024

Objective: To evaluate the association between meal timing and type 2 diabetes risk in U.S. Hispanic/Latino adults.Research Design and Methods: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, community-bas…

Loss of tumor suppressors promotes inflammatory tumor microenvironment and enhances LAG3+T cell mediated immune suppression Open

Sara Zahraeifard, Zhiguang Xiao, Jae Young So, Abdul Ahad, Selina Montoya , et al. · 2024

Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis Open

Monica Dinu, Francesco Sofi, Sofia Lotti, Barbara Colombini, Anna Vittoria Mattioli , et al. · 2024

Aims Benefits of pharmacologic omega-3 fatty acid administration in cardiovascular prevention are controversial. Particularly, effects on coronary revascularization are unclear; also debated are specific benefits of eicosapentaenoic acid (…

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