Nathan H. Dimmitt
YOU?
Author Swipe
View article: Aqueous Synthesis of Poly(ethylene glycol)‐Amide‐Norbornene‐Carboxylate for Modular Hydrogel Crosslinking
Aqueous Synthesis of Poly(ethylene glycol)‐Amide‐Norbornene‐Carboxylate for Modular Hydrogel Crosslinking Open
Poly(ethylene glycol)‐norbornene (e.g., PEGNB) is a versatile macromer amenable to step‐growth thiol‐norbornene photopolymerization and inverse electron demand Diels–Alder (iEDDA) click reaction. The translational potentials of PEGNB‐based…
View article: Hydrolytic degradation of PEG-based thiol–norbornene hydrogels enables multi-modal controlled release
Hydrolytic degradation of PEG-based thiol–norbornene hydrogels enables multi-modal controlled release Open
Poly(ethylene glycol)-norbornene (PEGNB) and PEGNB-carboxylate (PEGNB CA ) are photocrosslinked into hydrogels with highly tunable hydrolytic degradation to support multi-modal delivery of proteins with different sizes.
View article: Degradable and Multifunctional PEG-Based Hydrogels Formed by iEDDA Click Chemistry with Stable Click-Induced Supramolecular Interactions
Degradable and Multifunctional PEG-Based Hydrogels Formed by iEDDA Click Chemistry with Stable Click-Induced Supramolecular Interactions Open
The inverse electron demand Diels-Alder (iEDDA) reactions are highly efficient click chemistry increasingly utilized in bioconjugation, live cell labeling, and the synthesis and modification of biomaterials. iEDDA click reactions have also…
View article: Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins
Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins Open
Osteosarcoma (OS) is the common primary bone cancer that affects mostly children and young adults. To augment the standard-of-care chemotherapy, we examined the possibility of protein-based therapy using mesenchymal stem cells (MSCs)-deriv…
View article: Author response: Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins
Author response: Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Abstract Osteosarcoma (OS) is the commo…
View article: Dynamic and Stimuli-Responsive Hydrogel Systems for Controlled Release of Proteins
Dynamic and Stimuli-Responsive Hydrogel Systems for Controlled Release of Proteins Open
Background and HypothesisHydrogels have been extensively used as biomaterials for controlled release applications due to their biocompatibility and tunable networks. Stimuli-responsive, or smart, hydrogels are of interest due to their pote…
View article: Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins
Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins Open
Osteosarcoma (OS) is the common primary bone cancer that affects mostly children and young adults. To augment the standard-of-care chemotherapy, we examined the possibility of protein-based therapy using mesenchymal stem cells (MSCs)-deriv…
View article: Hydrolytically Degradable PEG-Based Inverse Electron Demand Diels–Alder Click Hydrogels
Hydrolytically Degradable PEG-Based Inverse Electron Demand Diels–Alder Click Hydrogels Open
Hydrogels cross-linked by inverse electron demand Diels-Alder (iEDDA) click chemistry are increasingly used in biomedical applications. With a few exceptions in naturally derived and chemically modified macromers, iEDDA click hydrogels exh…
View article: Injectable Acylhydrazone‐Linked RAFT Polymer Hydrogels for Sustained Protein Release and Cell Encapsulation (Adv. Healthcare Mater. 7/2022)
Injectable Acylhydrazone‐Linked RAFT Polymer Hydrogels for Sustained Protein Release and Cell Encapsulation (Adv. Healthcare Mater. 7/2022) Open
Injectable Hydrogels In article number 2101284 by Chien-Chi Lin and co-workers, a biocompatible and pH/thermo dual responsive injectable hydrogel is synthesized by reversible addition-fragmentation chain-transfer (RAFT) polymerization and …
View article: Injectable Acylhydrazone‐Linked RAFT Polymer Hydrogels for Sustained Protein Release and Cell Encapsulation
Injectable Acylhydrazone‐Linked RAFT Polymer Hydrogels for Sustained Protein Release and Cell Encapsulation Open
A new class of temperature responsive polymer, termed PADO, is synthesized by reversible addition‐fragmentation chain‐transfer polymerization. Synthesized from copolymerization of diacetone acrylamide (D A AM), di(ethylene glycol) ethyl et…
View article: Diagnosis of Agglomeration and Crystallinity of Active Pharmaceutical Ingredients in Over the Counter Headache Medication by Electrospray Laser Desorption Ionization Mass Spectrometry Imaging
Diagnosis of Agglomeration and Crystallinity of Active Pharmaceutical Ingredients in Over the Counter Headache Medication by Electrospray Laser Desorption Ionization Mass Spectrometry Imaging Open
Agglomeration of active pharmaceutical ingredients (API) in tablets can lead to decreased bioavailability in some enabling formulations. In a previous study, we determined that crystalline APIs can be detected as agglomeration in tablets f…
View article: Dynamic Click Hydrogels for Xeno‐Free Culture of Induced Pluripotent Stem Cells
Dynamic Click Hydrogels for Xeno‐Free Culture of Induced Pluripotent Stem Cells Open
Xeno‐free, chemically defined poly(ethylene glycol) (PEG)‐based hydrogels are being increasingly used for in vitro culture and differentiation of human induced pluripotent stem cells (hiPSCs). These synthetic matrices provide tunable gelat…