Nathan O. Kaplan
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View article: The contribution of moral injury to Israeli teachers’ mental health difficulties: the mediating role of shame and guilt
The contribution of moral injury to Israeli teachers’ mental health difficulties: the mediating role of shame and guilt Open
Introduction Exposure to potentially morally injurious events (PMIEs) has been found to contribute to mental health difficulties (MHD). However, research on PMIE exposure and its consequences among teachers is scant. In this study, we aime…
View article: Identification of novel, potent, and selective JAK2V617F inhibitors
Identification of novel, potent, and selective JAK2V617F inhibitors Open
The predominant oncogenic variant driving myeloproliferative neoplasms (MPNs) is the JAK2V617F substitution, where valine is replaced by phenylalanine in Janus kinase 2 (JAK2). Approximately 95% of polycythemia vera (PV) patients, and in o…
View article: 0900 Loss of Mrgprd+ sensory nerves delays wound healing by suppressing keratinocyte migration and exacerbating inflammatory states in fibroblasts and immune cells
0900 Loss of Mrgprd+ sensory nerves delays wound healing by suppressing keratinocyte migration and exacerbating inflammatory states in fibroblasts and immune cells Open
View article: Configurations of 10 points and their incidence varieties
Configurations of 10 points and their incidence varieties Open
Incidence varieties are spaces of $n$-tuples of points in the projective plane that satisfy a given set of collinearity conditions. We classify the components of incidence varieties and realization moduli spaces associated to configuration…
View article: On the smallest partition associated to a numerical semigroup
On the smallest partition associated to a numerical semigroup Open
The set of hook lengths of an integer partition $λ$ is the complement of some numerical semigroup $S$. There has been recent interest in studying the number of partitions with a given set of hook lengths. Very little is known about the dis…
View article: Most subrings of $\mathbb{Z}^n$ have large corank
Most subrings of $\mathbb{Z}^n$ have large corank Open
If $Λ\subseteq \mathbb{Z}^n$ is a sublattice of index $m$, then $\mathbb{Z}^n/Λ$ is a finite abelian group of order $m$ and rank at most $n$. Several authors have studied statistical properties of these groups as we range over all sublatti…
View article: The probability of non-isomorphic group structures of isogenous elliptic curves in finite field extensions, II
The probability of non-isomorphic group structures of isogenous elliptic curves in finite field extensions, II Open
Let E and E′ be 2-isogenous elliptic curves over Q. Following [6], we call a prime of good reduction p anomalous if E(Fp)≃E′(Fp) but E(Fp2)≄E′(Fp2). Our main result is an explicit formula for the proportion of anomalous primes for any such…
View article: Glucosylceramide synthase modulation ameliorates murine renal pathologies and promotes macrophage effector function in vitro
Glucosylceramide synthase modulation ameliorates murine renal pathologies and promotes macrophage effector function in vitro Open
While significant advances have been made in understanding renal pathophysiology, less is known about the role of glycosphingolipid (GSL) metabolism in driving organ dysfunction. Here, we used a small molecule inhibitor of glucosylceramide…
View article: Hulls of Projective Reed-Muller Codes
Hulls of Projective Reed-Muller Codes Open
Projective Reed-Muller codes are constructed from the family of projective hypersurfaces of a fixed degree over a finite field $\F_q$. We consider the relationship between projective Reed-Muller codes and their duals. We determine when the…
View article: Sums of Weighted Lattice Points of Polytopes
Sums of Weighted Lattice Points of Polytopes Open
We study the problem of counting lattice points of a polytope that are weighted by an Ehrhart quasi-polynomial of a family of parametric polytopes. As applications one can compute integrals and maximum values of such quasi-polynomials, as …
View article: The probability of non-isomorphic group structures of isogenous elliptic curves in finite field extensions, II
The probability of non-isomorphic group structures of isogenous elliptic curves in finite field extensions, II Open
Let $E$ and $E'$ be 2-isogenous elliptic curves over $\Q$. Following \cite{ck}, we call a good prime $p$ \emph{anomalous} if $E(\F_p) \simeq E'(\F_p)$ but $E(\F_{p^2}) \not \simeq E'(\F_{p^2})$. Our main result is an explicit formula for t…
View article: A Goldbach theorem for Laurent series semidomains
A Goldbach theorem for Laurent series semidomains Open
A semidomain is a subsemiring of an integral domain. One can think of a semidomain as an integral domain in which additive inverses are no longer required. A semidomain $S$ is additively reduced if $0$ is the only invertible element of the…
View article: Counting pairs of conics over finite fields that satisfy the Poncelet $n$-gon condition
Counting pairs of conics over finite fields that satisfy the Poncelet $n$-gon condition Open
An ordered pair of smooth conics satisfies the Poncelet triangle condition if there is a triangle inscribed in the first conic and circumscribed in the second conic. Over a finite field $\mathbb{F}_q$ with characteristic greater than $3$, …
View article: Enumerating numerical sets associated to a numerical semigroup
Enumerating numerical sets associated to a numerical semigroup Open
A numerical set T is a subset of N0 that contains 0 and has finite complement. The atom monoid of T is the set of x∈N0 such that x+T⊆T. Marzuola and Miller introduced the anti-atom problem: how many numerical sets have a given atom monoid?…
View article: Supplementary material from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation
Supplementary material from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation Open
Supplementary material.
View article: Data from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation
Data from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation Open
The tumor suppressor gene MEN1 is frequently mutated in sporadic pancreatic neuroendocrine tumors (PanNET) and is responsible for the familial multiple endocrine neoplasia type 1 (MEN-1) cancer syndrome. Menin, the protein product o…
View article: Table S1 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation
Table S1 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation Open
Table S1. H3K4me3 Peaks in RIP-Cre control
View article: Supplementary Fig. S5 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation
Supplementary Fig. S5 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation Open
Supplementary Fig. S5. Time-dependent epigenetic changes at the promoters of Men1-dependent targets
View article: Data from Identification of an “Exceptional Responder” Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy
Data from Identification of an “Exceptional Responder” Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy Open
The identification of somatic genetic alterations that confer sensitivity to pharmacologic inhibitors has led to new cancer therapies. To identify mutations that confer an exceptional dependency, shRNA-based loss-of-function data were anal…
View article: Table S4 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation
Table S4 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation Open
Table S4. Biological annotation for the top 25 genes
View article: Table S3 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation
Table S3 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation Open
Table S3. Differential H3k4me3 signal in Men1 KO pancreatic islet compared with RIP-Cre control
View article: Supplementary Fig. S3 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation
Supplementary Fig. S3 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation Open
Supplementary Fig. S3. Histone mark profiles in Hox genes
View article: Supplementary material from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation
Supplementary material from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation Open
Supplementary material.
View article: Supplementary Information Supplementary Figures 1-3, Supplemental Table 1, Supplemental Figure and Table Legends from Identification of an “Exceptional Responder” Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy
Supplementary Information Supplementary Figures 1-3, Supplemental Table 1, Supplemental Figure and Table Legends from Identification of an “Exceptional Responder” Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy Open
Characteristics of the 21 lung cancer cell lines assayed in the Project Achilles data set (8). NSCLC = non-small cell lung cancer, LCLC = large cell lung cancer, SCLC = small cell lung cancer. S1. Each data point represents the normalized …
View article: Data from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation
Data from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation Open
The tumor suppressor gene MEN1 is frequently mutated in sporadic pancreatic neuroendocrine tumors (PanNET) and is responsible for the familial multiple endocrine neoplasia type 1 (MEN-1) cancer syndrome. Menin, the protein product o…
View article: Supplementary Fig. S4 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation
Supplementary Fig. S4 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation Open
Supplementary Fig. S4. Relationship between H3K4me3 and H3K27me3 levels in Men1 target genes
View article: Data from Identification of an “Exceptional Responder” Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy
Data from Identification of an “Exceptional Responder” Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy Open
The identification of somatic genetic alterations that confer sensitivity to pharmacologic inhibitors has led to new cancer therapies. To identify mutations that confer an exceptional dependency, shRNA-based loss-of-function data were anal…
View article: Table S3 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation
Table S3 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation Open
Table S3. Differential H3k4me3 signal in Men1 KO pancreatic islet compared with RIP-Cre control
View article: Supplementary Fig. S2 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation
Supplementary Fig. S2 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation Open
Supplementary Fig. S2. Histone mark profiles in known menin targets
View article: Supplementary Fig. S2 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation
Supplementary Fig. S2 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation Open
Supplementary Fig. S2. Histone mark profiles in known menin targets