Nathan L. Asquith
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View article: Adjuvant conditioning enhances neutrophil function while inducing a suppressive peritoneal macrophage phenotype
Adjuvant conditioning enhances neutrophil function while inducing a suppressive peritoneal macrophage phenotype Open
Adjuvants are widely used to boost the immune response during vaccination protocols. Our group has previously reported that repeated intraperitoneal administration of alum in mice, known as adjuvant conditioning (AC), creates an immunosupp…
View article: The bone marrow is the primary site of thrombopoiesis
The bone marrow is the primary site of thrombopoiesis Open
Megakaryocytes (MKs) generate thousands of platelets over their lifespan. The roles of platelets in infection and inflammation has guided an interest to the study of extramedullary thrombopoiesis and therefore MKs have been increasingly re…
View article: A Critical Role for ERO1α in Arterial Thrombosis and Ischemic Stroke
A Critical Role for ERO1α in Arterial Thrombosis and Ischemic Stroke Open
Background: Platelet adhesion and aggregation play a crucial role in arterial thrombosis and ischemic stroke. Here, we identify platelet ERO1α (endoplasmic reticulum oxidoreductase 1α) as a novel regulator of Ca 2+ signaling and a potentia…
View article: Fibrin protofibril packing and clot stability are enhanced by extended knob-hole interactions and catch-slip bonds
Fibrin protofibril packing and clot stability are enhanced by extended knob-hole interactions and catch-slip bonds Open
Fibrin polymerization involves thrombin-mediated exposure of knobs on one monomer that bind to holes available on another, leading to the formation of fibers. In silico evidence has suggested that the classical A:a knob-hole interaction is…
View article: Fibrinogen αC-subregions critically contribute blood clot fibre growth, mechanical stability, and resistance to fibrinolysis
Fibrinogen αC-subregions critically contribute blood clot fibre growth, mechanical stability, and resistance to fibrinolysis Open
Fibrinogen is essential for blood coagulation. The C-terminus of the fibrinogen α-chain (αC-region) is composed of an αC-domain and αC-connector. Two recombinant fibrinogen variants (α390 and α220) were produced to investigate the role of …
View article: Author response: Fibrinogen αC-subregions critically contribute blood clot fibre growth, mechanical stability, and resistance to fibrinolysis
Author response: Fibrinogen αC-subregions critically contribute blood clot fibre growth, mechanical stability, and resistance to fibrinolysis Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Fibrinogen is essential for blood coagulat…
View article: Fibrinogen αC-subregions critically contribute blood clot fibre growth, mechanical stability and resistance to fibrinolysis
Fibrinogen αC-subregions critically contribute blood clot fibre growth, mechanical stability and resistance to fibrinolysis Open
Fibrinogen is essential for blood coagulation. The C-terminus of the fibrinogen α-chain (αC-region) is composed of an αC-domain and αC-connector. Two recombinant fibrinogen variants (α390 and α220) were produced to investigate the role of …
View article: Sniffing out the aroma(tase) of drug-induced thrombocytopenia
Sniffing out the aroma(tase) of drug-induced thrombocytopenia Open
In this issue of Blood, Tochigi et al made it their mission to understand the molecular mechanisms by which immunomodulatory drugs (IMiDs) induce thrombocytopenia. The authors use a combination of in vitro and ex vivo methods to show that …
View article: Teamwork makes the dream work in thrombopoiesis
Teamwork makes the dream work in thrombopoiesis Open
In this issue of Blood, Chiu et al report the presence of functional redundancy between the transcription factors lymphoblastic leukemia 1 protein (LYL1) and stem cell leukemia protein (SCL) in the process of megakaryocyte (MK) maturation …
View article: Extended D-E knob-hole interaction sites in fibrin polymerisation, clot formation and clot mechanics
Extended D-E knob-hole interaction sites in fibrin polymerisation, clot formation and clot mechanics Open
Background: Abnormal thrombus formation and occlusion of a vessel is one of the main events of cardiovascular disease. A main component of the thrombus is the protein fibrin, which is formed by proteolytic cleavage of its precursor fibrino…
View article: A fibrin biofilm covers blood clots and protects from microbial invasion
A fibrin biofilm covers blood clots and protects from microbial invasion Open
Hemostasis requires conversion of fibrinogen to fibrin fibers that generate a characteristic network, interact with blood cells, and initiate tissue repair. The fibrin network is porous and highly permeable, but the spatial arrangement of …
View article: Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis
Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis Open
Atherothrombosis is a leading cause of cardiovascular mortality and long-term morbidity. Platelets and coagulation proteases, interacting with circulating cells and in different vascular beds, modify several complex pathologies including a…
View article: Evaluation of an air–liquid interface cell culture model for studies on the inflammatory and cytotoxic responses to tobacco smoke aerosols
Evaluation of an air–liquid interface cell culture model for studies on the inflammatory and cytotoxic responses to tobacco smoke aerosols Open
In vitro toxicological studies for tobacco product assessment have traditionally been undertaken using the particulate phase of tobacco smoke. However, this does not truly reflect exposure conditions that occur in smokers. Thus in vitro ce…