Nathan L. Yozwiak
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View article: Comprehensive profiling of antibody responses to the human anellome using programmable phage display
Comprehensive profiling of antibody responses to the human anellome using programmable phage display Open
Anelloviruses represent a major constituent of the commensal human virome; however, little is known about their immunobiology. Here, we present "AnelloScan," a T7 phage library representing the open reading frame 1 (ORF1), ORF2, ORF3, and …
View article: Anellovirus Structure Reveals a Mechanism for Immune Evasion
Anellovirus Structure Reveals a Mechanism for Immune Evasion Open
The significant impact of the human virome on human physiology is beginning to emerge thanks to modern sequencing methods and bioinformatic tools 1 . Anelloviruses, the principal constituent of the commensal human virome, are universally a…
View article: Human anelloviruses produced by recombinant expression of synthetic genomes
Human anelloviruses produced by recombinant expression of synthetic genomes Open
Human anelloviruses are acquired universally in infancy, highly prevalent, abundant in blood, and extremely diverse. Their apparent lack of pathogenicity indicates that they are a major component of the commensal human virome. Despite thei…
View article: Comprehensive profiling of antibody responses to the human anellome using programmable phage display
Comprehensive profiling of antibody responses to the human anellome using programmable phage display Open
Viruses belonging to the diverse Anelloviridae family represent a major constituent of the commensal human virome. Aside from their widespread prevalence and persistence in humans and their absence of detectable pathologic associations, li…
View article: Combining genomics and epidemiology to track mumps virus transmission in the United States
Combining genomics and epidemiology to track mumps virus transmission in the United States Open
Unusually large outbreaks of mumps across the United States in 2016 and 2017 raised questions about the extent of mumps circulation and the relationship between these and prior outbreaks. We paired epidemiological data from public health i…
View article: Supplementary Data for "Combining genomics and epidemiology to track mumps virus transmission in the United States"
Supplementary Data for "Combining genomics and epidemiology to track mumps virus transmission in the United States" Open
Supplementary data and scripts used to produce figures for "Combining genomics and epidemiology to track mumps virus transmission in the United States." Files are divided into "code" and "data" directories and a README is provided for each.
View article: Supplementary Data for "Combining genomics and epidemiology to track mumps virus transmission in the United States"
Supplementary Data for "Combining genomics and epidemiology to track mumps virus transmission in the United States" Open
Supplementary data and scripts used to produce figures for "Combining genomics and epidemiology to track mumps virus transmission in the United States." Files are divided into "code" and "data" directories and a README is provided for each.
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data.tab Open
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View article: Genomic Analysis of Lassa Virus during an Increase in Cases in Nigeria in 2018
Genomic Analysis of Lassa Virus during an Increase in Cases in Nigeria in 2018 Open
During 2018, an unusual increase in Lassa fever cases occurred in Nigeria, raising concern among national and international public health agencies. We analyzed 220 Lassa virus genomes from infected patients, including 129 from the 2017-201…
View article: Co-circulating mumps lineages at multiple geographic scales
Co-circulating mumps lineages at multiple geographic scales Open
Despite widespread vaccination, eleven thousand mumps cases were reported in the United States (US) in 2016–17, including hundreds in Massachusetts, primarily in college settings. We generated 203 whole genome mumps virus (MuV) sequences f…
View article: Field-deployable viral diagnostics using CRISPR-Cas13
Field-deployable viral diagnostics using CRISPR-Cas13 Open
Taking CRISPR technology further CRISPR techniques are allowing the development of technologies for nucleic acid detection (see the Perspective by Chertow). Taking advantages of the distinctive enzymatic properties of CRISPR enzymes, Goote…
View article: Multiple introductions of Zika virus into the United States revealed through genomic epidemiology
Multiple introductions of Zika virus into the United States revealed through genomic epidemiology Open
Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital syndromes 1,2 . In July 2016, mosquito-borne ZIKV transmission was first reported in the continental United States and since then, hundreds of locally-acqui…
View article: Virus genomes reveal the factors that spread and sustained the West African Ebola epidemic
Virus genomes reveal the factors that spread and sustained the West African Ebola epidemic Open
Summary The 2013-2016 epidemic of Ebola virus disease in West Africa was of unprecedented magnitude, duration and impact. Extensive collaborative sequencing projects have produced a large collection of over 1600 Ebola virus genomes, repres…
View article: An Outbreak of Ebola Virus Disease in the Lassa Fever Zone
An Outbreak of Ebola Virus Disease in the Lassa Fever Zone Open
Responding to the challenges of confronting 2 hemorrhagic fever viruses will require continued investments in the development of countermeasures (vaccines, therapeutic agents, and diagnostic assays), infrastructure, and human resources.
View article: Ebola Virus Epidemiology and Evolution in Nigeria
Ebola Virus Epidemiology and Evolution in Nigeria Open
Containment limited the 2014 Nigerian Ebola virus (EBOV) disease outbreak to 20 reported cases and 8 fatalities. We present here clinical data and contact information for at least 19 case patients, and full-length EBOV genome sequences for…
View article: Discovery of Novel Rhabdoviruses in the Blood of Healthy Individuals from West Africa
Discovery of Novel Rhabdoviruses in the Blood of Healthy Individuals from West Africa Open
Next-generation sequencing (NGS) has the potential to transform the discovery of viruses causing unexplained acute febrile illness (UAFI) because it does not depend on culturing the pathogen or a priori knowledge of the pathogen's nucleic …
View article: Clinical Illness and Outcomes in Patients with Ebola in Sierra Leone
Clinical Illness and Outcomes in Patients with Ebola in Sierra Leone Open
This data comprises a total of 213 cases evaluated for Ebola virus infection at the Kenema Government Hospital in Sierra Leone between May 25 and June 18, 2014. Outcome data was available for 87 of 106 EBOV positive cases. Metabolic panels…
View article: Data sharing: Make outbreak research open access
Data sharing: Make outbreak research open access Open
Establish principles for rapid and responsible data sharing in epidemics, urge Nathan L. Yozwiak, Stephen F. Schaffner and Pardis C. Sabeti.