Nathan M. Ennist
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View article: Designed NGF mimetics with reduced nociceptive signatures in neurons
Designed NGF mimetics with reduced nociceptive signatures in neurons Open
The clinical use of Nerve Growth Factor (NGF) for neuronal regeneration has been hampered by pain sensitization side effects. NGF signals through the receptor tyrosine kinase TrkA and the co-receptor p75 NTR ; pain sensitization is thought…
View article: De novo design of proteins housing excitonically coupled chlorophyll special pairs
De novo design of proteins housing excitonically coupled chlorophyll special pairs Open
Natural photosystems couple light harvesting to charge separation using a ‘special pair’ of chlorophyll molecules that accepts excitation energy from the antenna and initiates an electron-transfer cascade. To investigate the photophysics o…
View article: Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site
Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site Open
The catalytic versatility of pentacoordinated iron is highlighted by the broad range of natural and engineered activities of heme enzymes such as cytochrome P450s, which position a porphyrin cofactor coordinating a central iron atom below …
View article: De novo design of energy transfer proteins housing excitonically coupled chlorophyll special pairs
De novo design of energy transfer proteins housing excitonically coupled chlorophyll special pairs Open
Natural photosystems couple light harvesting to charge separation using a “special pair” of chlorophyll molecules that accepts excitation energy from the antenna and initiates an electron-transfer cascade. To investigate the photophysics o…
View article: Rational design of photosynthetic reaction center protein maquettes
Rational design of photosynthetic reaction center protein maquettes Open
New technologies for efficient solar-to-fuel energy conversion will help facilitate a global shift from dependence on fossil fuels to renewable energy. Nature uses photosynthetic reaction centers to convert photon energy into a cascade of …
View article: De Novo Protein Design of Photochemical Reaction Centers
De Novo Protein Design of Photochemical Reaction Centers Open
Natural photosynthetic protein complexes capture sunlight to power the energetic catalysis that supports life on Earth. Yet these natural protein structures carry an evolutionary legacy of complexity and fragility that encumbers protein re…
View article: Design, Structure, And Action Of An Artificial Photosynthetic Reaction Center
Design, Structure, And Action Of An Artificial Photosynthetic Reaction Center Open
At the heart of photosystem II is the reaction center, where solar energy is used to separate charge. Set within a large and highly complex protein system, the handful of redox cofactors that make up the reaction center form an electron tr…