Nathan Manning
YOU?
Author Swipe
View article: Intra‐Arterial Thrombolysis After Successful Thrombectomy: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
Intra‐Arterial Thrombolysis After Successful Thrombectomy: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials Open
Background This study aims to conduct a systematic review and meta‐analysis of randomized controlled trials (RCTs) to assess the efficacy and safety of intra‐arterial thrombolysis (IAT) following successful endovascular thrombectomy (EVT) …
View article: Time to endovascular thrombectomy for acute ischaemic stroke in language other than English (LOTE) communities in South-Western Sydney
Time to endovascular thrombectomy for acute ischaemic stroke in language other than English (LOTE) communities in South-Western Sydney Open
Background Access to endovascular thrombectomy (EVT) for acute ischaemic stroke (AIS) and the outcome disparities in culturally and linguistically diverse (CALD) populations are understudied. South-Western Sydney (SWS), characterised by hi…
View article: Critical Care Decisions After Large Core Cerebral Infarctions: A Secondary Analysis From the <scp>SELECT2</scp> Trial
Critical Care Decisions After Large Core Cerebral Infarctions: A Secondary Analysis From the <span>SELECT2</span> Trial Open
Objective Among patients with large vessel occlusion (LVO) and large ischemic cores, critical decisions often need to be made about decompressive hemicraniectomy (DHC) or early withdrawal of life‐sustaining therapy (WLST). In this study, w…
View article: Association of Reperfusion and Procedural Characteristics with Endovascular Thrombectomy Outcomes in Large Core Stroke: Sub‐Analysis from the <scp>SELECT2</scp> Trial
Association of Reperfusion and Procedural Characteristics with Endovascular Thrombectomy Outcomes in Large Core Stroke: Sub‐Analysis from the <span>SELECT2</span> Trial Open
Endovascular thrombectomy (EVT) was shown to be safe and efficacious in patients with large core stroke in multiple randomized controlled trials. However, the impact of reperfusion and other procedural metrics on EVT outcomes in this popul…
View article: Abstract 414: Stroke Severity in patients presenting beyond 24 hours of last known well ‐ a secondary analysis of SELECT LATE cohort study
Abstract 414: Stroke Severity in patients presenting beyond 24 hours of last known well ‐ a secondary analysis of SELECT LATE cohort study Open
Introduction Endovascular thrombectomy (EVT) is shown to be associated with better clinical outcomes even after 24 hours of stroke onset. However, how stroke severity affect this association has not been well‐established. Methods From SELE…
View article: Relationship Between Baseline Infarct and Clinical Outcome in Pediatric Large‐Vessel Occlusion Ischemic Stroke
Relationship Between Baseline Infarct and Clinical Outcome in Pediatric Large‐Vessel Occlusion Ischemic Stroke Open
Background In adults with large‐vessel occlusion stroke, the extent of the baseline infarct measured using the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) predicts outcome and is used during patient selection for mecha…
View article: Insights into vessel perforations during thrombectomy: Characteristics of a severe complication and the effect of thrombolysis
Insights into vessel perforations during thrombectomy: Characteristics of a severe complication and the effect of thrombolysis Open
Introduction: Thrombectomy complications remain poorly explored. This study aims to characterize periprocedural intracranial vessel perforation including the effect of thrombolysis on patient outcomes. Patients and methods: In this multice…
View article: CTP for the Screening of Vasospasm and Delayed Cerebral Ischemia in Aneurysmal SAH: A Systematic Review and Meta-analysis
CTP for the Screening of Vasospasm and Delayed Cerebral Ischemia in Aneurysmal SAH: A Systematic Review and Meta-analysis Open
For delayed cerebral ischemia, CTP had a sensitivity of >80%, specificity of >75%, and a low negative likelihood ratio of 0.23. CTP had better performance for the detection of vasospasm, with sensitivity and specificity of >85% and a low n…
View article: Mechanical Thrombectomy for Pediatric Arterial Ischemic Stroke from Acute M2 Occlusion
Mechanical Thrombectomy for Pediatric Arterial Ischemic Stroke from Acute M2 Occlusion Open
Pediatric large-vessel occlusion has a poor natural history. Recent retrospective studies have demonstrated the potential benefits, feasibility, and safety profile of mechanical thrombectomy in children. However, the role of thrombectomy i…
View article: Endovascular Thrombectomy for Large Ischemic Stroke Across Ischemic Injury and Penumbra Profiles
Endovascular Thrombectomy for Large Ischemic Stroke Across Ischemic Injury and Penumbra Profiles Open
Importance Whether endovascular thrombectomy (EVT) efficacy for patients with acute ischemic stroke and large cores varies depending on the extent of ischemic injury is uncertain. Objective To describe the relationship between imaging esti…
View article: Surface modification of neurovascular stents: from bench to patient
Surface modification of neurovascular stents: from bench to patient Open
Flow-diverting stents (FDs) for the treatment of cerebrovascular aneurysms are revolutionary. However, these devices require systemic dual antiplatelet therapy (DAPT) to reduce thromboembolic complications. Given the risk of ischemic compl…
View article: Most endovascular thrombectomy patients have Target Mismatch despite absence of formal CT perfusion selection criteria
Most endovascular thrombectomy patients have Target Mismatch despite absence of formal CT perfusion selection criteria Open
Endovascular thrombectomy (EVT) is the standard of care for large vessel occlusion stroke. Use of Computed Tomographic Perfusion (CTP) to select EVT candidates is variable. The frequency of treatment and outcome in patients with unfavourab…
View article: Time to Reperfusion Is Not Associated With Functional Outcomes in First‐Pass Reperfusion: Analysis of the STRATIS Registry
Time to Reperfusion Is Not Associated With Functional Outcomes in First‐Pass Reperfusion: Analysis of the STRATIS Registry Open
Background Time is considered a fundamental driver of treatment success in ischemic stroke reperfusion therapy. First‐pass reperfusion (FPR) is associated with improved outcomes. We explored the association between time to reperfusion, FPR…
View article: Safety and Feasibility of Transradial Access for Neurointervention Procedures in Patients With Radial Artery Occlusion
Safety and Feasibility of Transradial Access for Neurointervention Procedures in Patients With Radial Artery Occlusion Open
Background Transradial access (TRA) has proven advantages in interventional cardiology and neurointervention. There is limited literature detailing radial artery occlusion (RAO) recanalization, and generally, RAO necessitates alternate acc…
View article: Association of Endovascular Thrombectomy vs Medical Management With Functional and Safety Outcomes in Patients Treated Beyond 24 Hours of Last Known Well
Association of Endovascular Thrombectomy vs Medical Management With Functional and Safety Outcomes in Patients Treated Beyond 24 Hours of Last Known Well Open
Importance The role of endovascular thrombectomy is uncertain for patients presenting beyond 24 hours of the time they were last known well. Objective To evaluate functional and safety outcomes for endovascular thrombectomy (EVT) vs medica…
View article: CT vascular territory mapping: a novel method to identify large vessel occlusion collateral
CT vascular territory mapping: a novel method to identify large vessel occlusion collateral Open
Introduction This descriptive study explores typical patterns of vascular territory mapping (VTM) in ischaemic stroke patients with proximal vessel occlusion. VTM is a novel process using CT perfusion that can identify the source and exten…
View article: Safety and Clinical Effectiveness of Pipeline Shield Device for Intracranial Aneurysms in an Australian Cohort (SCOPE‐AUS)
Safety and Clinical Effectiveness of Pipeline Shield Device for Intracranial Aneurysms in an Australian Cohort (SCOPE‐AUS) Open
Background The Pipeline Flex Embolization Device (PED) with Shield Technology (PED‐Shield) is a third‐generation flow diverting stents with surface modification designed to reduce platelet adhesion and thrombogenicity. We report the long‐t…
View article: How a Soviet Past Influences the Present: Vaccine Hesitancy in the Russian-speaking Population Today
How a Soviet Past Influences the Present: Vaccine Hesitancy in the Russian-speaking Population Today Open
The Russian-speaking population in the United States has shown a notoriously high prevalence of vaccine hesitancy. The same trends are present in the former Soviet republics. This was illuminated during the COVID-19 pandemic as World Healt…
View article: The Benefit of Endovascular Thrombectomy for Stroke on Functional Outcome Is Sustained at 12 Months
The Benefit of Endovascular Thrombectomy for Stroke on Functional Outcome Is Sustained at 12 Months Open
Background and Purpose: The short-term benefits of endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) have been widely documented, yet there is limited evidence to show that this is sustained in the long term. We aimed to dete…
View article: 027 Effect of inter-hospital transfer in patients undergoing endovascular thrombectomy in the early and late time window
027 Effect of inter-hospital transfer in patients undergoing endovascular thrombectomy in the early and late time window Open
Objective Assess the effect of inter-hospital transfer and treatment time on mortality, reperfusion rates and workflow time metrics in patients undergoing endovascular thrombectomy (EVT) for acute ischaemic stroke (AIS) due to large vessel…
View article: Traumatic intracranial nail-gun injury of the right internal carotid artery causing pseudoaneurysm and caroticocavernous fistula
Traumatic intracranial nail-gun injury of the right internal carotid artery causing pseudoaneurysm and caroticocavernous fistula Open
Penetrating trauma due to nail gun is an uncommon yet important clinical entity. There are numerous case reports describing these injuries, yet few describe those resulting in cerebrovascular injury. Laceration of cerebral blood vessels ma…
View article: 094 Novel <i>NOTCH1</i> variant in a patient with spontaneous internal carotid artery dissection
094 Novel <i>NOTCH1</i> variant in a patient with spontaneous internal carotid artery dissection Open
Introduction We report a case of spontaneous left internal carotid artery (ICA) dissection associated with a novel NOTCH1 variant. Case A 43-year-old lady presented with a 3-day history of severe headache and transient expressive dysphasia…
View article: Impact of interhospital transfer on patients undergoing endovascular thrombectomy for acute ischaemic stroke in an Australian setting
Impact of interhospital transfer on patients undergoing endovascular thrombectomy for acute ischaemic stroke in an Australian setting Open
Objective To assess the impact of interhospital transfer on the interplay between functional outcome, mortality, reperfusion rates and workflow time metrics in patients undergoing endovascular thrombectomy (EVT) for acute ischaemic stroke …
View article: O-010 Five-year australian experience with pipeline™ flex embolization devices with shield technology™: real world evidence (SCOPE-AUS)
O-010 Five-year australian experience with pipeline™ flex embolization devices with shield technology™: real world evidence (SCOPE-AUS) Open
Objective The Pipeline™ Flex Embolization Device with Shield Technology™ has been available in Australia for 4 years to treat intracranial aneurysms of the anterior and posterior circulation in both elective and ruptured presentations. The…
View article: Spontaneous cerebrospinal fluid rhinorrhoea and aspiration pneumonitis following initiation of continuous positive airway pressure treatment for obstructive sleep apnoea
Spontaneous cerebrospinal fluid rhinorrhoea and aspiration pneumonitis following initiation of continuous positive airway pressure treatment for obstructive sleep apnoea Open
Continuous positive airway pressure (CPAP) therapy is very often the treatment of choice for obstructive sleep apnoea (OSA). The association between intracranial hypertension and spontaneous cerebrospinal fluid (CSF) rhinorrhoea is being i…
View article: CJN volume 46 issue 3 Cover and Front matter
CJN volume 46 issue 3 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Functional Outcomes at 90 Days in Octogenarians Undergoing Thrombectomy for Acute Ischemic Stroke: A Prospective Cohort Study and Meta-Analysis
Functional Outcomes at 90 Days in Octogenarians Undergoing Thrombectomy for Acute Ischemic Stroke: A Prospective Cohort Study and Meta-Analysis Open
Background: Elderly patients account for 30% of acute ischemic stroke (AIS) but are under-represented in randomized controlled trials of endovascular thrombectomy (EVT). Meta-analysis of "real world" studies evaluating 90-day outcomes in e…
View article: Clot Histopathology in Ischemic Stroke with Infective Endocarditis
Clot Histopathology in Ischemic Stroke with Infective Endocarditis Open
Background: Endovascular thrombectomy (EVT) has shown efficacy in acute ischemic stroke (AIS) patients with infective endocarditis (IE). The possibility to undertake advanced histopathological clot analysis following EVT offers a new avenu…