N. Helge Meyer
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View article: Developing an approach for evaluating the cardiotoxic potential of botanicals
Developing an approach for evaluating the cardiotoxic potential of botanicals Open
Botanicals (e.g., extracts derived from plants, algae, or fungi) are increasingly utilized by consumers with the hope of enhancing their health, managing symptoms, or preventing ailments; however, these products have often had limited pre-…
View article: Table S1 from Impact of Physical Activity on Metastatic Cancer at Diagnosis and Mortality: Results from the Lifelines Cohort Study
Table S1 from Impact of Physical Activity on Metastatic Cancer at Diagnosis and Mortality: Results from the Lifelines Cohort Study Open
Table S1 shows cancer subtype distribution with stage at diagnosis and 2-year overall survival rate.
View article: Table S4 from Impact of Physical Activity on Metastatic Cancer at Diagnosis and Mortality: Results from the Lifelines Cohort Study
Table S4 from Impact of Physical Activity on Metastatic Cancer at Diagnosis and Mortality: Results from the Lifelines Cohort Study Open
Table S4 shows the logistic regression analysis of physical activity and metastatic cancer at diagnosis, excluding cancer patients diagnosed within the first year of follow-up (sensitivity analysis).
View article: Table S2 from Impact of Physical Activity on Metastatic Cancer at Diagnosis and Mortality: Results from the Lifelines Cohort Study
Table S2 from Impact of Physical Activity on Metastatic Cancer at Diagnosis and Mortality: Results from the Lifelines Cohort Study Open
Table S2 shows the cox regression analysis of physical activity and all-cause mortality, excluding cancer patients diagnosed within the first year of follow-up (sensitivity analysis).
View article: Data from Impact of Physical Activity on Metastatic Cancer at Diagnosis and Mortality: Results from the Lifelines Cohort Study
Data from Impact of Physical Activity on Metastatic Cancer at Diagnosis and Mortality: Results from the Lifelines Cohort Study Open
Background:Although higher pre-diagnosis physical activity is linked to lower mortality among cancer survivors, it is unclear whether this is due to a reduced likelihood of metastatic cancer at diagnosis. This study evaluated whether adher…
View article: Table S3 from Impact of Physical Activity on Metastatic Cancer at Diagnosis and Mortality: Results from the Lifelines Cohort Study
Table S3 from Impact of Physical Activity on Metastatic Cancer at Diagnosis and Mortality: Results from the Lifelines Cohort Study Open
Table S3 shows the logistic regression analysis of physical activity and metastatic cancer at diagnosis, stratified by the availability of population-based screening programs, gender, and BMI.
View article: Discrimination of Oxytocin, a Behavioral Neuropeptide Hormone, and Its Structural Variants by Nanopore
Discrimination of Oxytocin, a Behavioral Neuropeptide Hormone, and Its Structural Variants by Nanopore Open
Oxytocin, a neurohormone peptide, is implicated in various physiological processes, such as functions related to social behavior, reproduction, and emotional regulation. Recently, this peptide has been identified as a potential biomarker o…
View article: Impact of Physical Activity on Metastatic Cancer at Diagnosis and Mortality: Results from the Lifelines Cohort Study
Impact of Physical Activity on Metastatic Cancer at Diagnosis and Mortality: Results from the Lifelines Cohort Study Open
Background: Although higher pre-diagnosis physical activity is linked to lower mortality among cancer survivors, it is unclear whether this is due to a reduced likelihood of metastatic cancer at diagnosis. This study evaluated whether adhe…
View article: Nanopore sensing of protein and peptide conformation for point-of-care applications
Nanopore sensing of protein and peptide conformation for point-of-care applications Open
View article: Intracellular and extracellular activities of V-domain Ig-containing suppressor of T cell activation (VISTA) modulated by immunosuppressive factors of tumour microenvironment
Intracellular and extracellular activities of V-domain Ig-containing suppressor of T cell activation (VISTA) modulated by immunosuppressive factors of tumour microenvironment Open
V-domain Ig-containing suppressor of T cell activation (VISTA) is a unique immune checkpoint protein, which was reported to display both receptor and ligand activities. However, the mechanisms of regulation of VISTA activity and functions …
View article: It’s about TIME – Gal-9 as a potential immunotherapeutic target in pancreatic ductal adenocarcinoma
It’s about TIME – Gal-9 as a potential immunotherapeutic target in pancreatic ductal adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by an extremely poor prognosis and limited therapeutic options. Central to the progression and immune evasion of PDAC is the tumor (immune) …
View article: Preoperative Anemia as a Prognostic Risk Factor for Inferior Oncological Survival Following Resection for Pancreatic Ductal Adenocarcinoma
Preoperative Anemia as a Prognostic Risk Factor for Inferior Oncological Survival Following Resection for Pancreatic Ductal Adenocarcinoma Open
Objectives: A significant proportion of patients undergoing surgery for pancreatic ductal adenocarcinoma (PDAC) are anemic at the time of resection. In these patients, blood transfusions are omitted because of their potential negative impa…
View article: Protocol for autofluorescence-driven isolation of human peripheral blood eosinophils
Protocol for autofluorescence-driven isolation of human peripheral blood eosinophils Open
View article: Association Between Physical Activity and Pancreatic Cancer Risk and Mortality: A Systematic Review and Meta-Analysis
Association Between Physical Activity and Pancreatic Cancer Risk and Mortality: A Systematic Review and Meta-Analysis Open
Background: Physical activity has been associated with a lower risk of various types of cancer and reduced cancer-specific mortality. Less is known about its impact on pancreatic cancer. The aim of this systematic review and meta-analysis …
View article: Secondary Nucleation of Aβ Revealed by Single‐Molecule and Computational Approaches
Secondary Nucleation of Aβ Revealed by Single‐Molecule and Computational Approaches Open
Understanding the mechanisms underlying amyloid‐β (Aβ) aggregation is pivotal in the context of Alzheimer's disease. This study aims to elucidate the secondary nucleation process of Aβ42 peptides by combining experimental and computational…
View article: Unraveling the MicroRNA tapestry: exploring the molecular dynamics of locoregional recurrent rectal cancer
Unraveling the MicroRNA tapestry: exploring the molecular dynamics of locoregional recurrent rectal cancer Open
Introduction Colorectal cancer (CRC) ranks as the third most prevalent malignancy globally, with a concerning rise in incidence among young adults. Despite progress in understanding genetic predispositions and lifestyle risk factors, the i…
View article: Infiltration analysis of eosinophils and basophils and co‐expression of CD69, CD63, IL‐31 and IgE in patients with bullous and non‐bullous pemphigoid
Infiltration analysis of eosinophils and basophils and co‐expression of CD69, CD63, IL‐31 and IgE in patients with bullous and non‐bullous pemphigoid Open
The data that support the findings of this study are available upon request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
View article: The membrane-binding bacterial toxin long direct repeat D inhibits protein translation
The membrane-binding bacterial toxin long direct repeat D inhibits protein translation Open
Bacterial plasmids and chromosomes widely contain toxin-antitoxin (TA) loci, which are implicated in stress response, growth regulation and even tolerance to antibiotics and environmental stress. Type I TA systems consist of a stable toxin…
View article: Cross-Section Observational Study to Assess Antimicrobial Resistance Prevalence among Bovine Respiratory Disease Bacterial Isolates from Commercial US Feedlots
Cross-Section Observational Study to Assess Antimicrobial Resistance Prevalence among Bovine Respiratory Disease Bacterial Isolates from Commercial US Feedlots Open
Antimicrobial resistance (AMR) is a global public health threat that jeopardizes efficacy of antibiotics in veterinary and human medicine. Antibiotics are commonly administered to target the bacterial component of bovine respiratory diseas…
View article: Role of Epithelial-to-Mesenchymal Transition for the Generation of Circulating Tumors Cells and Cancer Cell Dissemination
Role of Epithelial-to-Mesenchymal Transition for the Generation of Circulating Tumors Cells and Cancer Cell Dissemination Open
Tumor-related death is primarily caused by metastasis; consequently, understanding, preventing, and treating metastasis is essential to improving clinical outcomes. Metastasis is mainly governed by the dissemination of tumor cells in the s…
View article: Editorial: Interactions of nanoparticles with and within living organisms—What can we learn to improve efficacy of nanomedicine?
Editorial: Interactions of nanoparticles with and within living organisms—What can we learn to improve efficacy of nanomedicine? Open
EDITORIAL article Front. Mol. Biosci., 18 October 2022Sec. Nanobiotechnology Volume 9 - 2022 | https://doi.org/10.3389/fmolb.2022.1044063
View article: Investigation of α‐Synuclein and Amyloid‐β(42)‐E22Δ Oligomers Using SiN Nanopore Functionalized with L‐Dopa
Investigation of α‐Synuclein and Amyloid‐β(42)‐E22Δ Oligomers Using SiN Nanopore Functionalized with L‐Dopa Open
Solid‐state nanopores are an emerging technology used as a high‐throughput, label‐free analytical method for the characterization of protein aggregation in an aqueous solution. In this work, we used Levodopamine to coat a silicon nitride n…
View article: Nanoparticle-based immunotherapy of pancreatic cancer
Nanoparticle-based immunotherapy of pancreatic cancer Open
Pancreatic cancer (PC) has a complex and unique tumor microenvironment (TME). Due to the physical barrier formed by the desmoplastic stroma, the delivery of drugs to the tumor tissue is limited. The TME also contributes to resistance to va…
View article: Macrophage Differentiation and Polarization Regulate the Release of the Immune Checkpoint Protein V-Domain Ig Suppressor of T Cell Activation
Macrophage Differentiation and Polarization Regulate the Release of the Immune Checkpoint Protein V-Domain Ig Suppressor of T Cell Activation Open
Recently, the V-domain immunoglobulin suppressor of T-cell activation (VISTA) was identified as a negative immune checkpoint regulator (NCR) that is mainly expressed in hematopoietic cells. Preclinical studies have shown that VISTA blockad…
View article: Expression of the Immune Checkpoint Protein VISTA Is Differentially Regulated by the TGF-β1 – Smad3 Signaling Pathway in Rapidly Proliferating Human Cells and T Lymphocytes
Expression of the Immune Checkpoint Protein VISTA Is Differentially Regulated by the TGF-β1 – Smad3 Signaling Pathway in Rapidly Proliferating Human Cells and T Lymphocytes Open
Immune checkpoint proteins play crucial roles in human embryonic development but are also used by cancer cells to escape immune surveillance. These proteins and biochemical pathways associated with them form a complex machinery capable of …
View article: Conical nanopores highlight the pro-aggregating effects of pyrimethanil fungicide on Aβ(1–42) peptides and dimeric splitting phenomena
Conical nanopores highlight the pro-aggregating effects of pyrimethanil fungicide on Aβ(1–42) peptides and dimeric splitting phenomena Open
View article: Structural and DNA-binding properties of the cytoplasmic domain of Vibrio cholerae transcription factor ToxR
Structural and DNA-binding properties of the cytoplasmic domain of Vibrio cholerae transcription factor ToxR Open
View article: Human basophils release the anti-inflammatory cytokine IL-10 following stimulation with α-melanocyte–stimulating hormone
Human basophils release the anti-inflammatory cytokine IL-10 following stimulation with α-melanocyte–stimulating hormone Open
View article: Ligand-Receptor Interactions of Galectin-9 and VISTA Suppress Human T Lymphocyte Cytotoxic Activity
Ligand-Receptor Interactions of Galectin-9 and VISTA Suppress Human T Lymphocyte Cytotoxic Activity Open
Acute myeloid leukemia (AML), a blood/bone marrow cancer, is a severe and often fatal malignancy. AML cells are capable of impairing the anti-cancer activities of cytotoxic lymphoid cells. This includes the inactivation of natural killer (…
View article: Structural fuzziness of the RNA-organizing protein SERF1a determines a toxic gain-of-interaction
Structural fuzziness of the RNA-organizing protein SERF1a determines a toxic gain-of-interaction Open
Members of the MOAG/SERF protein family have been attributed a neuropathologic significance because of their ability to enhance the proteotoxic polymerization of amyloidogenic proteins such as alpha-Synuclein (aSyn). However, the cellular …