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View article: Ground-based Reconnaissance Observations of 21 Exoplanet Atmospheres with the Exoplanet Transmission Spectroscopy Imager
Ground-based Reconnaissance Observations of 21 Exoplanet Atmospheres with the Exoplanet Transmission Spectroscopy Imager Open
One of the most prolific methods of studying exoplanet atmospheres is transmission spectroscopy, which measures the difference between the depth of an exoplanet's transit signal at various wavelengths and attempts to correlate the depth ch…
View article: 26P Lipidic and T cell characterization as prognostic biomarkers for patients with ER+ HER2- metastatic breast cancer (MBC) treated with CDK4/6 inhibitors (CDK4/6i)
26P Lipidic and T cell characterization as prognostic biomarkers for patients with ER+ HER2- metastatic breast cancer (MBC) treated with CDK4/6 inhibitors (CDK4/6i) Open
CDK 4/6i have dramatically improved the outcome of ER+/HER2- MBC, but most patients will eventually experience disease progression (PD). Dysregulation in lipid metabolism and T cell phenotypes may contribute to therapy resistance. We asses…
View article: 5PSQ-054 Evaluation of an application to help for the adequacy of the dosage of antibiotics in renal failure
5PSQ-054 Evaluation of an application to help for the adequacy of the dosage of antibiotics in renal failure Open
Background and Importance Due to the aging of the population, there are more and more patients with chronic renal failure who require prolonged hospitalisation. There are also many patients who, during a hospital admission, see their renal…
View article: Data from Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort
Data from Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort Open
Background: Chronic inflammation and oxidative stress are thought to be involved in colorectal cancer development. These processes may contribute to leakage of bacterial products, such as lipopolysaccharide (LPS) and flagellin, across the …
View article: Supplemental Tables S1-S3 from Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort
Supplemental Tables S1-S3 from Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort Open
Supplemental Table S1: ORs (95% CI) for risk of CRC by quartiles of baseline biomarkers of anti-LPS- and antiflagellin- IgA and IgG. Supplemental Table S2: ORs (95% CI) for risk of CRC by increasing levels of total bacterial exposure and h…
View article: Data from Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort
Data from Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort Open
Background: Chronic inflammation and oxidative stress are thought to be involved in colorectal cancer development. These processes may contribute to leakage of bacterial products, such as lipopolysaccharide (LPS) and flagellin, across the …
View article: Supplemental Tables S1-S3 from Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort
Supplemental Tables S1-S3 from Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort Open
Supplemental Table S1: ORs (95% CI) for risk of CRC by quartiles of baseline biomarkers of anti-LPS- and antiflagellin- IgA and IgG. Supplemental Table S2: ORs (95% CI) for risk of CRC by increasing levels of total bacterial exposure and h…
View article: Impact of SARS-CoV-2 infection in pregnant women and their babies: clinical and epidemiological features
Impact of SARS-CoV-2 infection in pregnant women and their babies: clinical and epidemiological features Open
Pregnant women with COVID-19 had higher risk of developing complications during pregnancy and their newborns were more likely to be admitted to NICU and had prematurity.
View article: Homologous Recombination Repair Gene Mutation Characterization by Liquid Biopsy: A Phase II Trial of Olaparib and Abiraterone in Metastatic Castrate-Resistant Prostate Cancer
Homologous Recombination Repair Gene Mutation Characterization by Liquid Biopsy: A Phase II Trial of Olaparib and Abiraterone in Metastatic Castrate-Resistant Prostate Cancer Open
Background: Phase III randomized trial data have confirmed the activity for olaparib in homologous recombination repair (HRR) mutated metastatic castration-resistant prostate cancer (mCRPC) post next-generation hormonal agent (NHA) progres…
View article: Follow-Up Study Confirms the Presence of Gastric Cancer DNA Methylation Hallmarks in High-Risk Precursor Lesions
Follow-Up Study Confirms the Presence of Gastric Cancer DNA Methylation Hallmarks in High-Risk Precursor Lesions Open
To adopt prevention strategies in gastric cancer, it is imperative to develop robust biomarkers with acceptable costs and feasibility in clinical practice to stratified populations according to risk scores. With this aim, we applied an unb…
View article: IL-18 and Lower Risk for Lung Cancer: Triangulated Evidence from Germline Predictions, Pre-Diagnostic Measurements, and Tumor Expression
IL-18 and Lower Risk for Lung Cancer: Triangulated Evidence from Germline Predictions, Pre-Diagnostic Measurements, and Tumor Expression Open
Lung cancer remains the most common cause of cancer death globally. Dysregulation of immune response and inflammatory signaling is known to play an important role in lung tumorigenesis, but the causal drivers of this process have yet to be…
View article: Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort
Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort Open
Experimental evidence has implicated genotoxic Escherichia coli (E. coli) and enterotoxigenic Bacteroides fragilis (ETBF) in the development of colorectal cancer (CRC). However, evidence from epidemiological studies is sparse. We therefore…
View article: Plasma vitamin C and type 2 diabetes: genome-wide association study and Mendelian randomization analysis in European populations
Plasma vitamin C and type 2 diabetes: genome-wide association study and Mendelian randomization analysis in European populations Open
Objective Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with ty…
View article: Plasma vitamin C and type 2 diabetes: genome-wide association study and Mendelian randomization analysis in European populations
Plasma vitamin C and type 2 diabetes: genome-wide association study and Mendelian randomization analysis in European populations Open
Objective Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with ty…
View article: Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations
Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations Open
OBJECTIVE Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with ty…
View article: PSA Kinetics as Prognostic Markers of Overall Survival in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Abiraterone Acetate
PSA Kinetics as Prognostic Markers of Overall Survival in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Abiraterone Acetate Open
Sofia España,1 Maria Ochoa de Olza,2 Nuria Sala,3 Josep Maria Piulats,2 Ulises Ferrandiz,1 Olatz Etxaniz,1 Lucia Heras,2,4 Oscar Buisan,5 Juan Carlos Pardo,1 Jose F Suarez,6 Pilar Barretina,3 Josep Comet,7 Xavier Garcia del Muro,2 Lauro Su…
View article: <p>PSA Kinetics as Prognostic Markers of Overall Survival in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Abiraterone Acetate</p>
PSA Kinetics as Prognostic Markers of Overall Survival in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Abiraterone Acetate Open
Our results indicate an association between PSA kinetics, especially early PSA response, and outcome to AA after progression to docetaxel. Taken together with other factors, lack of an early PSA response could identify patients who are unl…
View article: Metabolic perturbations prior to hepatocellular carcinoma diagnosis: Findings from a prospective observational cohort study
Metabolic perturbations prior to hepatocellular carcinoma diagnosis: Findings from a prospective observational cohort study Open
Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations in HCC is derived mostly from case‐control designs, with sparse information from prospective cohorts. Our objectiv…
View article: Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia Open
Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genom…
View article: Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations
Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations Open
Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes related to vita…
View article: rs12416605:C>T in <i>MIR938</i> associates with gastric cancer through affecting the regulation of the <i>CXCL12</i> chemokine gene
rs12416605:C>T in <i>MIR938</i> associates with gastric cancer through affecting the regulation of the <i>CXCL12</i> chemokine gene Open
Background MicroRNAs are small regulatory RNAs with important roles in carcinogenesis. Genetic variants in these regulatory molecules may contribute to disease. We aim to identify allelic variants in microRNAs as susceptibility factors to …
View article: THE RIPID AND LONG-TERM IMPACT OF ACUTE STRESS ON NEUROPLASTICITY. A NOVEL PARADIGM FOR DISSECTION OF STRESS RESPONSE
THE RIPID AND LONG-TERM IMPACT OF ACUTE STRESS ON NEUROPLASTICITY. A NOVEL PARADIGM FOR DISSECTION OF STRESS RESPONSE Open
The response to stressful events is physiologically required to adapt to external challenges. However, the stress response can either have a ?pro-adaptive? outcome, when the response is efficiently activated and then inactivated, or exert …
View article: Multimodal detection of homologous recombination repair gene mutations (HRRm) in a phase II trial of olaparib plus abiraterone in metastatic castrate resistant prostate cancer (mCRPC)
Multimodal detection of homologous recombination repair gene mutations (HRRm) in a phase II trial of olaparib plus abiraterone in metastatic castrate resistant prostate cancer (mCRPC) Open
Background: Study 8 [NCT01972217] was a randomized Phase II trial that tested the hypothesis that the combination of PARP inhibition plus abiraterone benefits unselected patients (pts) with mCRPC. The primary endpoint was progression-free …