Nathan Salomonis
YOU?
Author Swipe
View article: Bone marrow microenvironment retinoic acid receptor signaling represses multipotential progenitor dependent B cell lymphopoiesis through secretion of resistin
Bone marrow microenvironment retinoic acid receptor signaling represses multipotential progenitor dependent B cell lymphopoiesis through secretion of resistin Open
Lymphoid reconstitution following hematopoietic stem cell transplantation (HSCT) remains a significant clinical challenge. Incomplete immune recovery post-HSCT is associated with increased infection risk and non-relapse mortality. While he…
View article: A branched chain amino acid rheostat controls hematopoietic stem cell replicative lifespan
A branched chain amino acid rheostat controls hematopoietic stem cell replicative lifespan Open
Hematopoietic stem cells (HSCs) self-renew and give rise to all mature blood cells upon activation. However, studies using the histone H2B-GFP label-retention model have shown that HSCs progressively lose self-renewal ability with each div…
View article: Bone Marrow Adipokine Mediates Hematopoietic Regeneration and Stem Cell Fitness
Bone Marrow Adipokine Mediates Hematopoietic Regeneration and Stem Cell Fitness Open
Summary Bone marrow (BM) hematopoietic stem cells (HSCs) are exquisitely sensitive to cues from the BM microenvironment (ME), which is critical for their engraftment and regeneration following myeloablative stress. Retinoic acid signaling,…
View article: Bridging the gap of late-gestation nephrogenesis using a non-human primate model
Bridging the gap of late-gestation nephrogenesis using a non-human primate model Open
Background Prematurity is associated with low nephron endowment and an increased risk of chronic kidney disease. Human nephrogenesis is complete at 34-36 weeks gestation, with 60% of nephrons forming during the third trimester through late…
View article: Metallothionein 1 mediates growth and survival of <i>Dnmt3a;Npm1</i>-mutant acute myeloid leukemia
Metallothionein 1 mediates growth and survival of <i>Dnmt3a;Npm1</i>-mutant acute myeloid leukemia Open
Not available.
View article: Combinatorial therapy regimens targeting preclinical models of melanoma resistant to immune checkpoint blockade
Combinatorial therapy regimens targeting preclinical models of melanoma resistant to immune checkpoint blockade Open
Few effective therapeutic options exist after progression on immune checkpoint blockade (ICB) for melanoma. Here, we utilized a platform incorporating transcriptomic profiling, high-throughput drug screening, and murine models to demonstra…
View article: DEK promotes mammary hyperplasia and is associated with H3K27me3 epigenetic modifications
DEK promotes mammary hyperplasia and is associated with H3K27me3 epigenetic modifications Open
The DEK chromatin remodeling protein has oncogenic functions in breast cancers, but its functional role in normal mammary gland epithelium has remained unexplored. We developed two novel genetically engineered mouse models to study the rol…
View article: A survey of pathogenic involvement in non-communicable human diseases
A survey of pathogenic involvement in non-communicable human diseases Open
View article: Comprehensive characterization of human bone marrow microenvironment shows age-related changes
Comprehensive characterization of human bone marrow microenvironment shows age-related changes Open
Not available.
View article: Splicing regulatory dynamics for precision analysis and treatment of heterogeneous leukemias
Splicing regulatory dynamics for precision analysis and treatment of heterogeneous leukemias Open
The role of splicing dysregulation in cancer is underscored by splicing factor mutations; however, its impact in the absence of such rare mutations remains poorly understood. Prompted by the finding that splicing uniquely resolved genetic …
View article: Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms
Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms Open
View article: Genotype-immunophenotype relationships in<i>NPM1</i>-mutant AML clonal evolution uncovered by single cell multiomic analysis
Genotype-immunophenotype relationships in<i>NPM1</i>-mutant AML clonal evolution uncovered by single cell multiomic analysis Open
Acute myeloid leukemia (AML) is a multi-clonal disease, existing as a milieu of clones with unique but related genotypes as initiating clones acquire subsequent mutations. However, bulk sequencing cannot fully capture AML clonal architectu…
View article: Quantifying tumor specificity using Bayesian probabilistic modeling for drug and immunotherapeutic target discovery
Quantifying tumor specificity using Bayesian probabilistic modeling for drug and immunotherapeutic target discovery Open
View article: Obesity Uncovers the Presence of Inflammatory Lung Macrophage Subsets With an Adipose Tissue Transcriptomic Signature in Influenza Virus Infection
Obesity Uncovers the Presence of Inflammatory Lung Macrophage Subsets With an Adipose Tissue Transcriptomic Signature in Influenza Virus Infection Open
Obesity is an independent risk factor for increased disease severity during influenza A virus (IAV) infection. White adipose tissue (WAT) inflammation promotes disease pathogenesis in obesity. Whether obesity modifies lung and WAT immune c…
View article: An iPSC model of fragile X syndrome reflects clinical phenotypes and reveals m<sup>6</sup>A- mediated epi-transcriptomic dysregulation underlying synaptic dysfunction
An iPSC model of fragile X syndrome reflects clinical phenotypes and reveals m<sup>6</sup>A- mediated epi-transcriptomic dysregulation underlying synaptic dysfunction Open
Fragile X syndrome (FXS), the leading genetic cause of intellectual disability, arises from FMR1 gene silencing and loss of the FMRP protein. N6-methyladenosine (m 6 A) is a prevalent mRNA modification essential for post-transcriptional re…
View article: Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia
Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia Open
View article: The chromatin remodeler DEK promotes proliferation of mammary epithelium and is associated with H3K27me3 epigenetic modifications
The chromatin remodeler DEK promotes proliferation of mammary epithelium and is associated with H3K27me3 epigenetic modifications Open
The DEK chromatin remodeling protein was previously shown to confer oncogenic phenotypes to human and mouse mammary epithelial cells using in vitro and knockout mouse models. However, its functional role in normal mammary gland epithelium …
View article: miR-876-3p is a tumor suppressor on 9p21 that is inactivated in melanoma and targets ERK
miR-876-3p is a tumor suppressor on 9p21 that is inactivated in melanoma and targets ERK Open
Background While melanomas commonly harbor losses of 9p21, on which CDKN2A resides, the presence of additional tumor suppressor elements at this locus is incompletely characterized. Here we assess the expression levels and functional role …
View article: Cholestasis alters polarization and suppressor function of hepatic regulatory T cells.
Cholestasis alters polarization and suppressor function of hepatic regulatory T cells. Open
Fibrosing cholangiopathies, including biliary atresia and primary sclerosing cholangitis, involve immune-mediated bile duct epithelial injury and hepatic bile acid (BA) retention (cholestasis). Regulatory T-cells (Tregs) can prevent auto-r…
View article: An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors
An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors Open
Analysis of the human hematopoietic progenitor compartment is being transformed by single-cell multimodal approaches. Cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) enables coupled surface protein and transcripto…
View article: Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms
Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms Open
Summary Most human Transcription factors (TFs) genes encode multiple protein isoforms differing in DNA binding domains, effector domains, or other protein regions. The global extent to which this results in functional differences between i…
View article: Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation
Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation Open
The role of splicing dysregulation in cancer is underscored by splicing factor mutations; however, its impact in the absence of such rare mutations is poorly understood. To reveal complex patient subtypes and putative regulators of pathoge…
View article: Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy
Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy Open
Immunotherapy has emerged as a crucial strategy to combat cancer by “reprogramming” a patient’s own immune system. Although immunotherapy is typically reserved for patients with a high mutational burden, neoantigens produced from posttrans…
View article: An iPSC Model of Fragile X Syndrome Reflects Clinical Phenotypes and Reveals m6A-Mediated Epi-Transcriptomic Dysregulation Underlying Synaptic Dysfunction
An iPSC Model of Fragile X Syndrome Reflects Clinical Phenotypes and Reveals m6A-Mediated Epi-Transcriptomic Dysregulation Underlying Synaptic Dysfunction Open
View article: Sex-associated differences in frequencies and prognostic impact of recurrent genetic alterations in adult acute myeloid leukemia (Alliance, AMLCG)
Sex-associated differences in frequencies and prognostic impact of recurrent genetic alterations in adult acute myeloid leukemia (Alliance, AMLCG) Open
View article: Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions
Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions Open
The dynamics of the hematopoietic flux responsible for blood cell production in native conditions remains a matter of debate. Using CITE-seq analyses, we uncovered a distinct progenitor population that displays a cell cycle gene signature …
View article: Development of a Single-Neurosphere Culture to Assess Radiation Toxicity and Pre-Clinical Cancer Combination Therapy Safety
Development of a Single-Neurosphere Culture to Assess Radiation Toxicity and Pre-Clinical Cancer Combination Therapy Safety Open
Radiation therapy (RT) is a crucial treatment modality for central nervous system (CNS) tumors but toxicity to healthy CNS tissues remains a challenge. Additionally, environmental exposure to radiation during nuclear catastrophes or space …
View article: A potential acoustic role for CFTR ion channel in conductive hearing loss
A potential acoustic role for CFTR ion channel in conductive hearing loss Open
Loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF). The middle ear and eustachian tube could be adversely affected in CF. In this study, we provide evidence of the r…
View article: Population-level single-cell genomics reveals conserved gene programs in systemic juvenile idiopathic arthritis
Population-level single-cell genomics reveals conserved gene programs in systemic juvenile idiopathic arthritis Open
Systemic autoimmune and autoinflammatory diseases are characterized by genetic and cellular heterogeneity. While current single-cell genomics methods provide insights into known disease subtypes, these analysis methods do not readily revea…
View article: After the Infection: A Survey of Pathogens and Non-communicable Human Disease
After the Infection: A Survey of Pathogens and Non-communicable Human Disease Open
There are many well-established relationships between pathogens and human disease, but far fewer when focusing on non-communicable diseases (NCDs). We leverage data from The UK Biobank and TriNetX to perform a systematic survey across 20 p…