Tom N. McNeilly
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View article: Developing vaccines against gastrointestinal nematodes of sheep – The model matters
Developing vaccines against gastrointestinal nematodes of sheep – The model matters Open
View article: Host miRNAs regulate Escherichia coli O157 mucosal colonization through host-mucosa-attached microbiota interactions in calves
Host miRNAs regulate Escherichia coli O157 mucosal colonization through host-mucosa-attached microbiota interactions in calves Open
Introduction Host responses to pathogen colonization are central to understanding host homeostasis dynamics. Here, we used Shiga toxin (Stx)-producing Escherichia coli (STEC) O157 as an example to illustrate how pathogen colonization alter…
View article: Late pregnancy is associated with an increase in regulatory cytokines and a decline in nematode-specific antibody levels in sheep infected with Teladorsagia circumcincta
Late pregnancy is associated with an increase in regulatory cytokines and a decline in nematode-specific antibody levels in sheep infected with Teladorsagia circumcincta Open
The gastrointestinal nematode Teladorsagia circumcincta is a prevalent and economically important parasite of sheep. Sheep develop acquired immunity to T. circumcincta, characterised by nematode-specific antibody production and a type 2 T-…
View article: Detection of Cryptosporidium spp. and Giardia duodenalis DNA in wild deer in Scotland
Detection of Cryptosporidium spp. and Giardia duodenalis DNA in wild deer in Scotland Open
Cryptosporidium spp. and Giardia duodenalis are zoonotic pathogens that cause enteric disease in humans and animals. This study aimed to identify the species/assemblages of Cryptosporidium and Giardia duodenalis in Scottish wild deer popul…
View article: A 'green' toolbox: non-chemotherapeutic approaches for gastrointestinal nematode control in ruminants
A 'green' toolbox: non-chemotherapeutic approaches for gastrointestinal nematode control in ruminants Open
Grazing ruminants are commonly infected with gastrointestinal nematodes, and their negative impacts on animal health, welfare and production are intensified by increasing anthelmintic drug resistance. The goal of reducing anthelmintic use …
View article: Detection of abortifacient agents in domestic ruminants, with a specific focus on Coxiella burnetii
Detection of abortifacient agents in domestic ruminants, with a specific focus on Coxiella burnetii Open
Q fever is a widespread zoonotic disease caused by the bacterium, Coxiella burnetii. In ruminants, C. burnetii can cause abortions, stillbirths, premature births, and weak offspring. As part of the EU-funded Q-Net-Assess International Coor…
View article: Detection of abortifacient agents in domestic ruminants, with a specific focus on Coxiella burnetii
Detection of abortifacient agents in domestic ruminants, with a specific focus on Coxiella burnetii Open
Q fever is a widespread zoonotic disease caused by the bacterium, Coxiella burnetii . In ruminants, C. burnetii can cause abortions, stillbirths, premature births, and weak offspring. As part of the EU-funded Q-Net-Assess International Co…
View article: Detection of Cryptosporidium Spp. And Giardia DNA in Wild Deer in Scotland
Detection of Cryptosporidium Spp. And Giardia DNA in Wild Deer in Scotland Open
View article: Late Pregnancy is Associated with an Increase in Regulatory Cytokines and a Decline in Nematode-Specific Antibody Levels in Sheep Infected with Teladorsagia Circumcincta
Late Pregnancy is Associated with an Increase in Regulatory Cytokines and a Decline in Nematode-Specific Antibody Levels in Sheep Infected with Teladorsagia Circumcincta Open
View article: T-helper cell phenotypes are repeatable, positively correlated, and associated with helminth infection in wild Soay sheep
T-helper cell phenotypes are repeatable, positively correlated, and associated with helminth infection in wild Soay sheep Open
Background T-helper (Th) cells co-ordinate immune responses to ensure that infections with diverse parasites are controlled effectively. Helminth parasites such as gastrointestinal nematodes (GIN) are generally associated with T-helper typ…
View article: Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta
Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta Open
The parasitic nematode Teladorsagia circumcincta is one of the most important pathogens of sheep and goat farming in temperate climates worldwide and can rapidly evolve resistance to drugs used to control it. To understand the genetics of …
View article: Host resources and parasite traits interact to determine the optimal combination of host parasite‐mitigation strategies
Host resources and parasite traits interact to determine the optimal combination of host parasite‐mitigation strategies Open
Organisms have evolved diverse strategies to manage parasite infections. Broadly, hosts may avoid infection by altering behaviour, resist infection by targeting parasites or tolerate infection by repairing associated damage. The effectiven…
View article: Host resources and parasite traits interact to determine the optimal combination of host parasite-mitigation strategies
Host resources and parasite traits interact to determine the optimal combination of host parasite-mitigation strategies Open
1. Organisms have evolved diverse strategies to manage parasite infections. Broadly, hosts may avoid infection by altering behaviour, resist infection by targeting parasites, or tolerate infection by repairing associated damage. Effectiven…
View article: Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity
Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity Open
View article: No correlative evidence of costs of infection or immunity on leucocyte telomere length in a wild population of Soay sheep
No correlative evidence of costs of infection or immunity on leucocyte telomere length in a wild population of Soay sheep Open
Telomere length (TL) is a biomarker hypothesized to capture evolutionarily and ecologically important physiological costs of reproduction, infection and immunity. Few studies have estimated the relationships among infection status, immunit…
View article: Field testing of recombinant subunit vaccines against Teladorsagia circumcincta in lambing ewes demonstrates a lack of efficacy in the face of a multi-species parasite challenge
Field testing of recombinant subunit vaccines against Teladorsagia circumcincta in lambing ewes demonstrates a lack of efficacy in the face of a multi-species parasite challenge Open
Introduction We previously demonstrated efficacy of an 8-antigen recombinant subunit vaccine against a single species homologous Teladorsagia circumcincta challenge in lambs and in lambing ewes in pen trials. We subsequently demonstrated e…
View article: Characterisation of protective vaccine antigens from the thiol-containing components of excretory/secretory material of Ostertagia ostertagi
Characterisation of protective vaccine antigens from the thiol-containing components of excretory/secretory material of Ostertagia ostertagi Open
View article: Identification of protein expression changes in milk in experimental bovine mastitis using difference gel electrophoresis
Identification of protein expression changes in milk in experimental bovine mastitis using difference gel electrophoresis Open
In order to identify the extent of protein changes in milk during mastitis as a guide to detecting markers for prompt management of the disease, milk from cows in which clinical mastitis was experimentally induced were subjected to differe…
View article: Genome-wide association studies of parasite resistance, productivity and immunology traits in Scottish Blackface sheep
Genome-wide association studies of parasite resistance, productivity and immunology traits in Scottish Blackface sheep Open
Gastrointestinal parasitism represents a global problem for grazing ruminants, which can be addressed sustainably by breeding animals to be more resistant against infection by parasites. The aim of this study was to assess the genetic arch…
View article: Linking active rectal mucosa–attached microbiota to host immunity reveals its role in host–pathogenic STEC O157 interactions
Linking active rectal mucosa–attached microbiota to host immunity reveals its role in host–pathogenic STEC O157 interactions Open
The rectal–anal junction (RAJ) is the major colonization site of Shiga toxin–producing Escherichia coli (STEC) O157 in beef cattle, leading to transmission of this foodborne pathogen from farms to food chains. To date, there is limited und…
View article: Genetic profile of adaptive immune traits and relationships with parasite resistance and productivity in Scottish Blackface sheep
Genetic profile of adaptive immune traits and relationships with parasite resistance and productivity in Scottish Blackface sheep Open
View article: Tuft cell-derived acetylcholine is an effector of type 2 immunity and directly targets helminth parasites in the gut lumen
Tuft cell-derived acetylcholine is an effector of type 2 immunity and directly targets helminth parasites in the gut lumen Open
SUMMARY Upon parasitic helminth infection, activated intestinal tuft cells secrete IL-25, which initiates a type 2 immune response during which lamina propria ILC2s produce IL-13. This causes epithelial remodelling, including tuft cell hyp…
View article: Characterisation of protective vaccine antigens from the thiol-containing components of excretory/secretory material of<i>Ostertagia ostertagi</i>
Characterisation of protective vaccine antigens from the thiol-containing components of excretory/secretory material of<i>Ostertagia ostertagi</i> Open
Previous vaccination trials have demonstrated that thiol proteins affinity purified from Ostertagia ostertagi excretory-secretory products ( O. ostertagi ES-thiol) are protective against homologous challenge. Here we have shown that protec…
View article: Genome-wide epitope mapping across multiple host species reveals significant diversity in antibody responses to Coxiella burnetii vaccination and infection
Genome-wide epitope mapping across multiple host species reveals significant diversity in antibody responses to Coxiella burnetii vaccination and infection Open
Coxiella burnetii is an important zoonotic bacterial pathogen of global importance, causing the disease Q fever in a wide range of animal hosts. Ruminant livestock, in particular sheep and goats, are considered the main reservoir of human …
View article: Antagonism between co-infecting gastrointestinal nematodes: A meta-analysis of experimental infections in Sheep
Antagonism between co-infecting gastrointestinal nematodes: A meta-analysis of experimental infections in Sheep Open
Gastrointestinal nematodes (GIN) have enormous global impacts in humans, wildlife and grazing livestock. Within grazing livestock, sheep are of particular global importance and the economics and sustainability of sheep production are great…
View article: Tuft Cells: Detectors, Amplifiers, Effectors and Targets in Parasite Infection
Tuft Cells: Detectors, Amplifiers, Effectors and Targets in Parasite Infection Open
Tuft cells have recently emerged as the focus of intense interest following the discovery of their chemosensory role in the intestinal tract, and their ability to activate Type 2 immune responses to helminth parasites. Moreover, they popul…
View article: A curated multivariate approach to study efficacy and optimisation of a prototype vaccine against teladorsagiasis in sheep
A curated multivariate approach to study efficacy and optimisation of a prototype vaccine against teladorsagiasis in sheep Open
View article: Analysis of Escherichia coli O157 strains in cattle and humans between Scotland and England & Wales: implications for human health
Analysis of Escherichia coli O157 strains in cattle and humans between Scotland and England & Wales: implications for human health Open
For the last two decades, the human infection frequency of Escherichia coli O157 (O157) in Scotland has been 2.5-fold higher than in England and Wales. Results from national cattle surveys conducted in Scotland and England and Wales in 201…
View article: Prevalence of Shiga Toxin-Producing Escherichia coli O157 in Wild Scottish Deer with High Human Pathogenic Potential
Prevalence of Shiga Toxin-Producing Escherichia coli O157 in Wild Scottish Deer with High Human Pathogenic Potential Open
Shiga toxin-producing E. coli (STEC) infections associated with wildlife are increasing globally, highlighting many ‘spillover’ species as important reservoirs for these zoonotic pathogens. A human outbreak of STEC serogroup O157 in 2015 i…
View article: Immune markers in goats selected for reduced gastrointestinal nematode egg count under artificial infection conditions
Immune markers in goats selected for reduced gastrointestinal nematode egg count under artificial infection conditions Open
This study aimed to further investigate the mechanisms responsible for inhibition of gastrointestinal nematode egg production in a line of Scottish Cashmere Goat selected for low faecal egg count. Animals were chosen as the lowest egg prod…