Nathaniel Bloodworth
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View article: Machine learning application to predict binding affinity between peptide containing non-canonical amino acids and HLA-A0201
Machine learning application to predict binding affinity between peptide containing non-canonical amino acids and HLA-A0201 Open
Class Ι major histocompatibility complexes (MHC-Ι), encoded by the highly polymorphic HLA-A, HLA-B, and HLA-C genes in humans, are expressed on all nucleated cells. Both self and foreign proteins are processed to peptides of 8–10 amino aci…
View article: Machine learning application to predict binding affinity between peptide containing non-canonical amino acids and HLA0201
Machine learning application to predict binding affinity between peptide containing non-canonical amino acids and HLA0201 Open
Class 1 major histocompatibility complexes (MHC-I), encoded by the highly polymorphic HLA-A, HLA-B, and HLA-C genes in humans, are expressed on all nucleated cells. Both self and foreign proteins are processed to peptides of 8 to 10 amino …
View article: A Chemical Approach to Assess the Impact of Post-translational Modification on MHC Peptide Binding and Effector Cell Engagement
A Chemical Approach to Assess the Impact of Post-translational Modification on MHC Peptide Binding and Effector Cell Engagement Open
The human major histocompatibility complex (MHC) plays a pivotal role in the presentation of peptidic fragments from proteins, which can originate from self-proteins or from nonhuman antigens, such as those produced by viruses or bacteria.…
View article: Posttranslationally modified self-peptides promote hypertension in mouse models
Posttranslationally modified self-peptides promote hypertension in mouse models Open
Posttranslational modifications can enhance immunogenicity of self-proteins. In several conditions, including hypertension, systemic lupus erythematosus, and heart failure, isolevuglandins (IsoLGs) are formed by lipid peroxidation and cova…
View article: The Antioxidative Effects of Flavones in Hypertensive Disease
The Antioxidative Effects of Flavones in Hypertensive Disease Open
Hypertension is the leading remediable risk factor for cardiovascular morbidity and mortality in the United States. Excess dietary salt consumption, which is a catalyst of hypertension, initiates an inflammatory cascade via activation of a…
View article: Discovery of post-translationally modified self-peptides that promote hypertension
Discovery of post-translationally modified self-peptides that promote hypertension Open
Post translational modifications can enhance immunogenicity of self-proteins. In several conditions including hypertension, systemic lupus, and heart failure, isolevuglandins (IsoLGs) are formed by lipid peroxidation and covalently bond wi…
View article: Impact of Post-Translational Modification on MHC Peptide Binding and TCR Engagement
Impact of Post-Translational Modification on MHC Peptide Binding and TCR Engagement Open
The human major histocompatibility complex (MHC) plays a crucial role in the presentation of peptidic fragments from proteins; these peptides can be derived from self-proteins or from non-human antigens, such as those produced by viruses o…
View article: Rosetta FlexPepDock to predict peptide-MHC binding: An approach for non-canonical amino acids
Rosetta FlexPepDock to predict peptide-MHC binding: An approach for non-canonical amino acids Open
Computation methods that predict the binding of peptides to MHC-I are important tools for screening and identifying immunogenic antigens and have the potential to accelerate vaccine and drug development. However, most available tools are s…
View article: Bone Marrow–Derived Proangiogenic Cells Mediate Pulmonary Arteriole Stiffening via Serotonin 2B Receptor Dependent Mechanism
Bone Marrow–Derived Proangiogenic Cells Mediate Pulmonary Arteriole Stiffening via Serotonin 2B Receptor Dependent Mechanism Open
Rationale: Pulmonary arterial hypertension is a deadly disease of the pulmonary vasculature for which no disease-modifying therapies exist. Small-vessel stiffening and remodeling are fundamental pathological features of pulmonary arterial …
View article: Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction
Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction Open
Pulmonary vascular disease is characterized by remodeling and loss of microvessels and is typically attributed to pathological responses in vascular endothelium or abnormal smooth muscle cell phenotypes. We have challenged this understandi…
View article: Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension
Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension Open
Serotonergic anorexigens are the primary pharmacologic risk factor associated with pulmonary arterial hypertension (PAH), and the resulting PAH is clinically indistinguishable from the heritable form of disease, associated with BMPR2 mutat…