Nathaniel Hubert
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View article: The Microbiome of an Outpatient Sports Medicine Clinic During a Global Pandemic: Effects of Implementation of a Microbiome-Specific Cleaning Program
The Microbiome of an Outpatient Sports Medicine Clinic During a Global Pandemic: Effects of Implementation of a Microbiome-Specific Cleaning Program Open
Outpatient healthcare facilities represent potential sources of healthcare-associated infections (HAIs). The purpose of this study was to survey high-contact surfaces in an outpatient physical therapy clinic, characterize the microbiome of…
View article: Emodin Inhibited Pathological Cardiac Hypertrophy in Response to Angiotensin-Induced Hypertension and Altered the Gut Microbiome
Emodin Inhibited Pathological Cardiac Hypertrophy in Response to Angiotensin-Induced Hypertension and Altered the Gut Microbiome Open
Objective: Evidence suggests that food bioactives affect the epigenome to prevent pathological cardiac hypertrophy. Recently, we showed that emodin, an anthraquinone, attenuated pathological cardiac hypertrophy and histone deacetylase (HDA…
View article: The microbiome of an outpatient rehabilitation clinic and predictors of contamination: A pilot study
The microbiome of an outpatient rehabilitation clinic and predictors of contamination: A pilot study Open
Background Understanding sources of microbial contamination in outpatient rehabilitation (REHAB) clinics is important to patients and healthcare providers. Purpose The purpose of this study was to characterize the microbiome of an outpatie…
View article: Selective Regional Alteration of the Gut Microbiota by Diet and Antibiotics
Selective Regional Alteration of the Gut Microbiota by Diet and Antibiotics Open
The small intestinal microbiota has recently been implicated in contributing to metabolic disease. We previously demonstrated that diets rich in saturated milk fat have a particularly strong impact on the small bowel microbiota as opposed …
View article: High fat diet disrupts diurnal interactions between REG3γ and small intestinal gut microbes resulting in metabolic dysfunction
High fat diet disrupts diurnal interactions between REG3γ and small intestinal gut microbes resulting in metabolic dysfunction Open
Summary Gut microbial diurnal oscillations are important diet-dependent drivers of host circadian rhythms and metabolism that ensure optimal energy balance. Yet, the interplay between diet, microbes, and host factors that sustain intestina…
View article: Phenylpropionc acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity
Phenylpropionc acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity Open
Acetaminophen (APAP) overdose causes hepatic injury and is major contributor to acute liver injury cases. To investigate potential roles of gut microbiota in APAP-induced liver injury, C57BL/6 mice from Jackson (JAX) or Taconic (TAC) were …
View article: Data on changes to mucosal inflammation and the intestinal microbiota following dietary micronutrients in genetically susceptible hosts
Data on changes to mucosal inflammation and the intestinal microbiota following dietary micronutrients in genetically susceptible hosts Open
These data support the findings that dietary micronutrients influence the inflammatory responses and intestinal microbial community structure and function in a model of pouchitis-like small bowel inflammation reported in "Dietary Antioxida…
View article: Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone Offspring
Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone Offspring Open
Factors affecting the developing neonatal gut microbiome and immune networks may increase the risk of developing complex immune disorders such as inflammatory bowel diseases (IBD). In particular, peripartum antibiotics have been suggested …
View article: Mutual reinforcement of pathophysiological host‐microbe interactions in intestinal stasis models
Mutual reinforcement of pathophysiological host‐microbe interactions in intestinal stasis models Open
Chronic diseases arise when there is mutual reinforcement of pathophysiological processes that cause an aberrant steady state. Such a sequence of events may underlie chronic constipation, which has been associated with dysbiosis of the gut…
View article: Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis
Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis Open
The UC pouch, well before histologic inflammation, already displays a systems-level gain of colon-associated genes and loss of ileum-associated genes. Patients with UC exhibit a unique transcriptomic response to ileal pouch creation that c…
View article: Additional file 2: Table S1. of Tracking microbial colonization in fecal microbiota transplantation experiments via genome-resolved metagenomics
Additional file 2: Table S1. of Tracking microbial colonization in fecal microbiota transplantation experiments via genome-resolved metagenomics Open
Additional information for samples, metagenomic bins, and metagenome-assembled genomes in our study. (XLSX 180Â kb)
View article: Additional file 1: Table S3. of Tracking microbial colonization in fecal microbiota transplantation experiments via genome-resolved metagenomics
Additional file 1: Table S3. of Tracking microbial colonization in fecal microbiota transplantation experiments via genome-resolved metagenomics Open
Phylogenomic relationships between our MAGs and a collection of 1758 reference genomes. (XLSX 775Â kb)
View article: Additional file 6: Table S2. of Tracking microbial colonization in fecal microbiota transplantation experiments via genome-resolved metagenomics
Additional file 6: Table S2. of Tracking microbial colonization in fecal microbiota transplantation experiments via genome-resolved metagenomics Open
The canonical correspondence analysis (CCA) of 500 functions and 107 sub-systems. (XLSX 240 kb)
View article: High-resolution tracking of microbial colonization in Fecal Microbiota Transplantation experiments via metagenome-assembled genomes
High-resolution tracking of microbial colonization in Fecal Microbiota Transplantation experiments via metagenome-assembled genomes Open
Fecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridium difficile infection and shows promise for treating other medical conditions associated with intestinal dysbioses. However, we lack a sufficient unde…
View article: Vancomycin treatment and butyrate supplementation modulate gut microbe composition and severity of neointimal hyperplasia after arterial injury
Vancomycin treatment and butyrate supplementation modulate gut microbe composition and severity of neointimal hyperplasia after arterial injury Open
Gut microbial metabolites are increasingly recognized as determinants of health and disease. However, whether host -: microbe crosstalk influences peripheral arteries is not understood. Neointimal hyperplasia, a proliferative and inflammat…
View article: Commensal <i>Bifidobacterium</i> promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Commensal <i>Bifidobacterium</i> promotes antitumor immunity and facilitates anti–PD-L1 efficacy Open
Gut microbes affect immunotherapy The unleashing of antitumor T cell responses has ushered in a new era of cancer treatment. Although these therapies can cause dramatic tumor regressions in some patients, many patients inexplicably see no …