Explanipedia

mRNA-1273.251 and mRNA-1283.251 vaccines expressing SARS-CoV-2 variant LP.8.1 antigens broadly neutralize contemporary JN.1-lineage viruses Open

Arshan Nasir, Diana Lee, Ziqiu Wang, Clinton O. Ogega, Nathen E. Bopp , et al. · 2025

The continued evolution of the SARS-CoV-2 Omicron JN.1 lineage has led to the emergence of antigenically distinct subvariants including KP.2, KP.3, XEC, and LP.8.1, which became the dominant strains in the Americas and Europe by mid-2025. …

West Nile Virus and Epizootic Hemorrhagic Disease Virus Co-Infection in a Novel Host at the Nashville Zoo Open

Abelardo C. Moncayo, T. E. Moore, Nathen E. Bopp, Heather E. Robertson, Margarita Woc Colburn , et al. · 2023

On August 30, 2017, one of five bontebok in a mixed-species exhibit at the Nashville Zoo at Grassmere exhibited acute hind-limb ataxia and altered demeanor. Pathological examination demonstrated meningoencephalitis and spinal myelitis. Coi…

Arbovirus Antibody Seroprevalence in the Human Population from Cauca, Colombia Open

Juliana Gil-Mora, Leidy Y. Acevedo-Gutiérrez, Paola Betancourt-Ruiz, H Diaz, Diana Fernández , et al. · 2022

Several arboviruses have emerged or reemerged into the New World during the past several decades, causing outbreaks of significant proportion. In particular, the outbreaks of Dengue virus (DENV), Zika virus, and Chikungunya virus (CHIKV) h…

Publisher Correction: A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions Open

Yang Liu, Xianwen Zhang, Jianying Liu, Hongjie Xia, Jing Zou , et al. · 2022

A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions Open

Yang Liu, Xianwen Zhang, Jianying Liu, Hongjie Xia, Jing Zou , et al. · 2022

We report a live-attenuated SARS-CoV-2 vaccine candidate with (i) re-engineered viral transcription regulator sequences and (ii) deleted open-reading-frames (ORF) 3, 6, 7, and 8 (∆3678). The ∆3678 virus replicates about 7,500-fold lower th…

Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis Open

Bryan A. Johnson, Yiyang Zhou, Kumari G. Lokugamage, Michelle N. Vu, Nathen E. Bopp , et al. · 2022

While SARS-CoV-2 continues to adapt for human infection and transmission, genetic variation outside of the spike gene remains largely unexplored. This study investigates a highly variable region at residues 203–205 in the SARS-CoV-2 nucleo…

A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions Open

Yang Liu, Xianwen Zhang, Jianying Liu, Hongjie Xia, Jing Zou , et al. · 2022

We report a live-attenuated SARS-CoV-2 vaccine candidate with (i) re-engineered viral transcriptional regulator sequences and (ii) deleted open-reading-frames (ORF) 3, 6, 7, and 8 (Δ3678). The Δ3678 virus replicates about 7,500-fold lower …

Analytical characterization of the SARS-CoV-2 EURM-017 reference material Open

James A. Freeman, Katherine Oakley Olson, Justin Conklin, Victoria Shalhoub, Bryan A. Johnson , et al. · 2021

Serological Responses in Patients Infected with Mayaro Virus and Evaluation of Cross-Protective Responses against Chikungunya Virus Open

Nathen E. Bopp, Kara J. Jencks, Crystyan Siles, Carolina Guevara, Stalin Vilcarromero , et al. · 2021

Mayaro virus (MAYV) is an alphavirus endemic to both Latin America and the Caribbean. Recent reports have questioned the ability of MAYV and its close relative, Chikungunya virus (CHIKV), to generate cross-reactive, neutralizing antibodies…

Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis Open

Bryan A. Johnson, Yiyang Zhou, Kumari G. Lokugamage, Michelle N. Vu, Nathen E. Bopp , et al. · 2021

While SARS-CoV-2 continues to adapt for human infection and transmission, genetic variation outside of the spike gene remains largely unexplored. This study investigates a highly variable region at residues 203-205 in the SARS-CoV-2 nucleo…

THE EVOLUTION OF THERMOTOLERANCE A CHARACTERIZATION OF A DIRECTIONALLY EVOLVED CYANOBACTERIUM Open

Nathen E. Bopp · 2021

Chaperone proteins are essential components in the maintenance and turnover of the proteome. Many chaperones play integral functions in the folding and unfolding of cellular substrates under many conditions, including heat stress. Most cha…

Potent Antiviral Activity against HSV-1 and SARS-CoV-2 by Antimicrobial Peptoids Open

Gill Diamond, Natalia Molchanova, Claudine Herlan, John A. Fortkort, Jennifer S Lin , et al. · 2021

Viral infections, such as those caused by Herpes Simplex Virus-1 (HSV-1) and SARS-CoV-2, affect millions of people each year. However, there are few antiviral drugs that can effectively treat these infections. The standard approach in the …

Mechanisms of Sporicidal Activity Induced by Ionized Hydrogen Peroxide in the Spores of <i>Bacillus atrophaeus</i> Open

Miguel A. Grimaldo, Nicole L. Mendell, Nathen E. Bopp, Donald H. Bouyer, Cláudio Mafra · 2021

Introduction: Ionized hydrogen peroxide (iHP) is a new technology used for the decontamination of surfaces or laboratory areas. It utilizes a low concentration of hydrogen peroxide (H₂O₂) mixed with air and ion…

Antiviral activity of oleandrin and a defined extract of Nerium oleander against SARS-CoV-2 Open

Kenneth S. Plante, Varun Dwivedi, Jessica A. Plante, Diana Fernández, Divya Mirchandani , et al. · 2021

With continued expansion of the coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), both antiviral drugs as well as effective vaccines are desperately needed to treat patients at high risk o…

A trans-complementation system for SARS-CoV-2 recapitulates authentic viral replication without virulence Open

Xianwen Zhang, Yang Liu, Jianying Liu, Adam L. Bailey, Kenneth S. Plante , et al. · 2021

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis Open

Bryan A. Johnson, Xuping Xie, Adam L. Bailey, Birte Kalveram, Kumari G. Lokugamage , et al. · 2021

A<i>trans</i>-complementation system for SARS-CoV-2 Open

Xianwen Zhang, Yang Liu, Jianying Liu, Adam L. Bailey, Kenneth S. Plante , et al. · 2021

The biosafety level-3 (BSL-3) requirement to culture severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a bottleneck for research and countermeasure development. Here we report a trans -complementation system that produces sin…

Baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development Open

Nathen E. Bopp, Jaclyn A. Kaiser, Ashley E. Strother, Alan D.T. Barrett, David W. C. Beasley , et al. · 2020

Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis Open

Bryan A. Johnson, Xuping Xie, Birte Kalveram, Kumari G. Lokugamage, Antonio E. Muruato , et al. · 2020

SARS-CoV-2 has resulted in a global pandemic and shutdown economies around the world. Sequence analysis indicates that the novel coronavirus (CoV) has an insertion of a furin cleavage site (PRRAR) in its spike protein. Absent in other grou…

Prophylactic and Therapeutic Inhibition of In Vitro SARS-CoV-2 Replication by Oleandrin Open

Kenneth S. Plante, Jessica A. Plante, Diana Fernández, Divya Mirchandani, Nathen E. Bopp , et al. · 2020

With continued expansion of the COVID-19 pandemic, antiviral drugs are desperately needed to treat patients at high risk of life-threatening disease and even to limit spread if administered early during infection. Typically, the fastest ro…

Multicycle Autoclave Decontamination of N95 Filtering Facepiece Respirators Open

Nathen E. Bopp, Donald H. Bouyer, Christopher M. Gibbs, Joan E. Nichols, Corrie A. Ntiforo , et al. · 2020

The study finds that specific surgical masks and N95 FFR models can withstand autoclave decontamination for up to three cycles. Additionally, the autoclave cycles tested were those that could be readily achieved by both clinical and resear…

An Infectious cDNA Clone of SARS-CoV-2 Open

Xuping Xie, Antonio E. Muruato, Kumari G. Lokugamage, Krishna Narayanan, Xianwen Zhang , et al. · 2020

Real-time RT-PCR for the detection and quantitation of Oropouche virus Open

Alejandra Rojas, Victoria Stittleburg, Fátima Cardozo, Nathen E. Bopp, César Cantero , et al. · 2019

Protective immunity by an engineered DNA vaccine for Mayaro virus Open

Hyeree Choi, Sagar B. Kudchodkar, Emma L. Reuschel, Kanika Asija, Piyush Borole , et al. · 2019

Mayaro virus (MAYV) of the genus alphavirus is a mosquito-transmitted emerging infectious disease that causes an acute febrile illness, rash, headaches, and nausea that may turn into incapacitating, persistent arthralgias in some victims. …

Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection Open

Huanle Luo, E. Winkelmann, Shuang Zhu, Wenjuan Ru, Elizabeth Mays , et al. · 2018

The E3 ubiquitin ligase Pellino 1 (Peli1) is a microglia-specific mediator of autoimmune encephalomyelitis. Its role in neurotropic flavivirus infection is largely unknown. Here, we report that mice deficient in Peli1 (Peli1-/-) were more …

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