Nathieli B. Bottari
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View article: Diagnostic Performance of Chimeric Recombinant Antigens of <i>Trypanosoma cruzi</i> for Identifying Chagas Disease in Samples From Rio Grande do Sul
Diagnostic Performance of Chimeric Recombinant Antigens of <i>Trypanosoma cruzi</i> for Identifying Chagas Disease in Samples From Rio Grande do Sul Open
Background Chagas disease, caused by Trypanosoma cruzi , remains a significant public health challenge in Latin America, with diagnostic limitations hindering control efforts. Aim Our study aimed to assess the diagnostic performance of fou…
View article: Resveratrol Alleviates Inflammatory Response Through P2X7/NLRP3 Signaling Pathway: In Silico and In Vitro Evidence from Activated Microglia
Resveratrol Alleviates Inflammatory Response Through P2X7/NLRP3 Signaling Pathway: In Silico and In Vitro Evidence from Activated Microglia Open
Background/Objectives: Chronic inflammation and inappropriate NLRP3 inflammasome regulation are related to many brain diseases. Purinergic mediators may play an important role in inflammation regulation and could be targeted for effective …
View article: Microalgae-Derived Carotenoid Extract and Biomass Reduce Viability, Induce Oxidative Stress, and Modulate the Purinergic System in Two Melanoma Cell Lines
Microalgae-Derived Carotenoid Extract and Biomass Reduce Viability, Induce Oxidative Stress, and Modulate the Purinergic System in Two Melanoma Cell Lines Open
Cutaneous melanoma (CM) is an aggressive and metastatic tumor, resulting in high mortality rates. Despite significant advances in therapeutics, the available treatments still require improvements. Thus, purinergic signaling emerged as a po…
View article: Effects of Free and Nanoencapsulated Benznidazole in Acute Trypanosoma cruzi Infection: Role of Cholinergic Pathway and Redox Status
Effects of Free and Nanoencapsulated Benznidazole in Acute Trypanosoma cruzi Infection: Role of Cholinergic Pathway and Redox Status Open
Background/Objectives: The Trypanosoma cruzi infection promotes an intense inflammatory process that affects several tissues. The cholinergic system may exert a regulatory immune response and control the inflammatory process. This study ai…
View article: A Pilot Evaluation of Oxidative Stress Markers and Peripheral Blood Mononuclear Cell Cytokine mRNA of Atopic Dermatitis Dogs Treated with Full Spectrum Cannabis Oil
A Pilot Evaluation of Oxidative Stress Markers and Peripheral Blood Mononuclear Cell Cytokine mRNA of Atopic Dermatitis Dogs Treated with Full Spectrum Cannabis Oil Open
Dermatological consultations are a significant aspect of daily operations at small animal clinics, with atopic dermatitis (CAD) affecting almost 15% of the canine population. The ECS role in the skin reveals its direct action on homeostasi…
View article: Associação de ciclosporina e óleo de cannabis em um cão com dermatite atópica
Associação de ciclosporina e óleo de cannabis em um cão com dermatite atópica Open
Background: O sistema endocanabinoidoma (eCBoma) é um complexo de interações entre substâncias endocanabinoides, enzimas e diversos receptores presentes em todo o organismo. Dessa forma, a terapia canábica, com seus fitocanabinoides, entra…
View article: Can the Inclusion of a Vegetable Biocholine Additive in Pig Feed Contaminated with Aflatoxin Reduce Toxicological Impacts on Animal Health and Performance?
Can the Inclusion of a Vegetable Biocholine Additive in Pig Feed Contaminated with Aflatoxin Reduce Toxicological Impacts on Animal Health and Performance? Open
(1) Background: This study’s objective was to determine whether adding vegetable biocholine (VB) to pigs’ diets would minimize the negative effects caused by daily aflatoxin (B1 + B2) intake. (2) Methods: We used seventy-two whole male pig…
View article: Curcumin modulates neurogliogenesis and purinergic receptor expression in neural precursor cells infected with Toxoplasma gondii
Curcumin modulates neurogliogenesis and purinergic receptor expression in neural precursor cells infected with Toxoplasma gondii Open
View article: USE OF A HOMEOPATHIC PRODUCT IN DOGS REDUCES THE NEGATIVE EFFECTS OF CANINE ATOPIC DERMATITIS
USE OF A HOMEOPATHIC PRODUCT IN DOGS REDUCES THE NEGATIVE EFFECTS OF CANINE ATOPIC DERMATITIS Open
This study aimed to determine whether a homeopathic product formulated based on Hepar sulfur, Rhus toxicodendron, Graphites, and Urtica urens would prevent atopic dermatitis in dogs. Ten male beagle dogs were used, divided into two groups …
View article: OS EFEITOS DA CAPSAICINA E SEU USO COMO UM POTENCIAL AGENTE TERAPÊUTICO NO TRATAMENTO DO CÂNCER: UM REVISÃO SISTEMÁTICA DA LITERATURA
OS EFEITOS DA CAPSAICINA E SEU USO COMO UM POTENCIAL AGENTE TERAPÊUTICO NO TRATAMENTO DO CÂNCER: UM REVISÃO SISTEMÁTICA DA LITERATURA Open
Introdução: O câncer é o principal problema de saúde pública no mundo, por esse motivo é imprescindível uma busca por novos compostos que apresentem atividade antitumoral. Cerca de 50% dos medicamentos quimioterápicos disponíveis no mercad…
View article: Addition of a blend of essential oils (cloves, rosemary and oregano) and vitamin E to replace conventional chemical antioxidants in dog feed: effects on food quality and health of beagles
Addition of a blend of essential oils (cloves, rosemary and oregano) and vitamin E to replace conventional chemical antioxidants in dog feed: effects on food quality and health of beagles Open
This study aimed to produce dog food containing natural antioxidants (blend of essential oils and vitamin E) to replace synthetic antioxidants and determine the effects on food conservation and animal health sequentially. The foods were pr…
View article: Piglet Feed Contaminated with Aflatoxin B1 and Supplemented with an Anti-Mycotoxin Blend: Impact on Health and Zootechnical Performance
Piglet Feed Contaminated with Aflatoxin B1 and Supplemented with an Anti-Mycotoxin Blend: Impact on Health and Zootechnical Performance Open
The present study aimed to determine whether the inclusion of a mixture based on Saccharomyces cerevisiae lysate, zeolite, silicon dioxide, propylene glycol, Carduus marianus extract, soy lecithin, and carbonate in the piglet diet would be…
View article: Involvement of ectonucleotidases and purinergic receptor expression during acute Chagas disease in the cortex of mice treated with resveratrol and benznidazole
Involvement of ectonucleotidases and purinergic receptor expression during acute Chagas disease in the cortex of mice treated with resveratrol and benznidazole Open
View article: Impact of Free Curcumin and Curcumin Nanocapsules on Viability and Oxidative Status of Neural Cell Lines
Impact of Free Curcumin and Curcumin Nanocapsules on Viability and Oxidative Status of Neural Cell Lines Open
View article: Diabetes and hypertension: Pivotal involvement of purinergic signaling
Diabetes and hypertension: Pivotal involvement of purinergic signaling Open
Diabetes mellitus (DM) and hypertension are highly prevalent worldwide health problems and frequently associated with severe clinical complications, such as diabetic cardiomyopathy, nephropathy, retinopathy, neuropathy, stroke, and cardiac…
View article: A sinalização purinérgica no contexto da fisiopatologia da toxoplasmose
A sinalização purinérgica no contexto da fisiopatologia da toxoplasmose Open
parasito a fim de perpetuar-se nas células.Estudos têm demonstrado a compreensão do papel desempenhado pela sinalização purinérgica contra inúmeros invasores intracelulares, incluindo o T. gondii, e como esta via de
View article: Neuroprotective role of resveratrol mediated by purinergic signalling in cerebral cortex of mice infected by Toxoplasma gondii
Neuroprotective role of resveratrol mediated by purinergic signalling in cerebral cortex of mice infected by Toxoplasma gondii Open
View article: Crosstalk between the Purinergic and Immune Systems: Implications for the Glutathione Antioxidant System in Health and Disease
Crosstalk between the Purinergic and Immune Systems: Implications for the Glutathione Antioxidant System in Health and Disease Open
Glutathione (GSH) represents the major nonprotein thiol in cells and, alongside with glutathione-dependent enzymes such as glutathione reductase (GR), glutathione peroxidase (GPx), and glutathione S-transferase (GST), exerts several biolog…
View article: Effect of differing amounts of microalgae (Schizochytrium limacinum) added via milk on performance and antioxidant capacity of dairy calves
Effect of differing amounts of microalgae (Schizochytrium limacinum) added via milk on performance and antioxidant capacity of dairy calves Open
This study evaluated the effect of different amounts of marine microalgae (Schizochytrium limacinum) via milk on performance, serum constituents and antioxidant indicators of dairy calves. Twenty-four Holstein calves were distributed to on…
View article: Aluminum-induced alterations of purinergic signalling in embryonic neural progenitor cells
Aluminum-induced alterations of purinergic signalling in embryonic neural progenitor cells Open
View article: Dietary addition of curcumin favors weight gain and has antioxidant, antiinflammatory and anticoccidial action in dairy calves
Dietary addition of curcumin favors weight gain and has antioxidant, antiinflammatory and anticoccidial action in dairy calves Open
Background: Curcumin has been used as an additive in the diet of animals in recent years due to the potent medicinal properties of this molecule. Objective: To evaluate whether the addition of curcumin to the diet of calves at different ph…
View article: Trypanosoma evansi impacts on embryonic neural progenitor cell functions
Trypanosoma evansi impacts on embryonic neural progenitor cell functions Open
View article: Aluminum affects neural phenotype determination of embryonic neural progenitor cells
Aluminum affects neural phenotype determination of embryonic neural progenitor cells Open
View article: Effects of resveratrol on the differentiation fate of neural progenitor cells of mouse embryos infected with Trypanosoma cruzi
Effects of resveratrol on the differentiation fate of neural progenitor cells of mouse embryos infected with Trypanosoma cruzi Open
View article: Experimental Infection by Brucella ovis: Changes in NTPDase, 5'-Nucleotidase and Acetylcholinesterase Associated Cerebral Oxidative Stres
Experimental Infection by Brucella ovis: Changes in NTPDase, 5'-Nucleotidase and Acetylcholinesterase Associated Cerebral Oxidative Stres Open
Background: Changes in purinergic and cholinergic signaling have been demonstrated in various pathologies associated with inflammation; however, the changes in brucellosis caused by the Gram-negative coccobacillus Brucella ovis are not kno…
View article: Effects of fed mycotoxin contaminated diets supplemented with spray-dried porcine plasma on cholinergic response and behavior in piglets
Effects of fed mycotoxin contaminated diets supplemented with spray-dried porcine plasma on cholinergic response and behavior in piglets Open
The aim of this study was to evaluate the effect of spray-dried porcine plasma (SDPP) supplementation on cholinesterase enzymes and its relationship with animal behavior of weaning piglets exposed to mycotoxin contaminated diets. To achiev…
View article: Health benefits of subcutaneous zinc edetate and diphenyl diselenide in calves during the weaning period
Health benefits of subcutaneous zinc edetate and diphenyl diselenide in calves during the weaning period Open
The aims of this study were to investigate whether treatments with zinc edetate (Zn) and diphenyl diselenide ((PhSe)2) enhance performance, immune responses, protein metabolism, and oxidant/antioxidant status in calf serum and muscle. Anim…
View article: Health benefits of subcutaneous zinc edetate and diphenyl diselenide in calves during the weaning period
Health benefits of subcutaneous zinc edetate and diphenyl diselenide in calves during the weaning period Open
The aims of this study were to investigate whether treatments with zinc edetate (Zn) and diphenyl diselenide ((PhSe)2) enhance performance, immune responses, protein metabolism, and oxidant/antioxidant status in calf serum and muscle. Anim…
View article: Resveratrol-mediated reversal of changes in purinergic signaling and immune response induced by Toxoplasma gondii infection of neural progenitor cells
Resveratrol-mediated reversal of changes in purinergic signaling and immune response induced by Toxoplasma gondii infection of neural progenitor cells Open
View article: La adición de diseleniuro de difenilo en las dietas de codorniz mejora la calidad de la carne
La adición de diseleniuro de difenilo en las dietas de codorniz mejora la calidad de la carne Open
Objetivo. El diseleniuro de difenilo (Ph2Se2) es un compuesto de selenio orgánico que es conocido por sus características antioxidantes. Por lo tanto, el objetivo de este estudio fue evaluar si Ph2Se2 en las dietas de codorniz (Coturnix ja…