Nayaab S Khan
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View article: Publisher Correction: Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis
Publisher Correction: Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis Open
[This corrects the article DOI: 10.1038/s44161-023-00278-y.].
View article: Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis
Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis Open
The development of new immunotherapies to treat the inflammatory mechanisms that sustain atherosclerotic cardiovascular disease (ASCVD) is urgently needed. Herein, we present a path to drug repurposing to identify immunotherapies for ASCVD…
View article: Some Revenge Now or More Revenge Later? Applying an Intertemporal Framework to Retaliatory Aggression
Some Revenge Now or More Revenge Later? Applying an Intertemporal Framework to Retaliatory Aggression Open
Retaliatory aggression is a rewarding behavior. Decisions about rewarding behaviors often involve an intertemporal bias, such that people prefer immediate rewards and discount delayed rewards. We integrated these literatures to test whethe…
View article: Repurposing the atypical antidepressant trazodone for atherosclerotic cardiovascular disease
Repurposing the atypical antidepressant trazodone for atherosclerotic cardiovascular disease Open
Background. Current lipid-lowering drugs often leave significant residual risk for adverse outcomes. Identification of previously approved drugs for new indications, drug repurposing, may provide a cost effective alternative to de novo dru…
View article: Peripherally Selective CB1 Receptor Antagonist Improves Symptoms of Metabolic Syndrome in Mice
Peripherally Selective CB1 Receptor Antagonist Improves Symptoms of Metabolic Syndrome in Mice Open
Metabolic syndrome (MetS) is a complex disorder that stems from the additive effects of multiple underlying causes such as obesity, insulin resistance, and chronic low-grade inflammation. The endocannabinoid system plays a central role in …
View article: Immune Profiling of Atherosclerotic Plaques Identifies Innate and Adaptive Dysregulations Associated with Ischemic Cerebrovascular Events
Immune Profiling of Atherosclerotic Plaques Identifies Innate and Adaptive Dysregulations Associated with Ischemic Cerebrovascular Events Open
SUMMARY Atherosclerosis is driven by multifaceted contributions of the immune system within the circulation and at vascular focal sites. Yet the specific immune dysregulations within the atherosclerotic lesions that lead to clinical cerebr…
View article: Brain Cytosolic Phospholipase A2α Mediates Angiotensin II-Induced Hypertension and Reactive Oxygen Species Production in Male Mice
Brain Cytosolic Phospholipase A2α Mediates Angiotensin II-Induced Hypertension and Reactive Oxygen Species Production in Male Mice Open
BACKGROUND Recently, we reported that angiotensin II (Ang II)-induced hypertension is mediated by group IV cytosolic phospholipase A2α (cPLA2α) via production of prohypertensive eicosanoids. Since Ang II increases blood pressure (BP) via i…
View article: 2-Methoxyestradiol Reduces Angiotensin II–Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice
2-Methoxyestradiol Reduces Angiotensin II–Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice Open
Cytochrome P450 1B1 protects against angiotensin II (Ang II)–induced hypertension and associated cardiovascular changes in female mice, most likely via production of 2-methoxyestradiol. This study was conducted to determine whether 2-metho…
View article: Nicotinic Acetylcholine Receptor-Mediated Protection of the Rat Heart Exposed to Ischemia Reperfusion
Nicotinic Acetylcholine Receptor-Mediated Protection of the Rat Heart Exposed to Ischemia Reperfusion Open
Reperfusion injury following acute myocardial infarction is associated with significant morbidity. Activation of neuronal or non-neuronal cholinergic pathways in the heart has been shown to reduce ischemic injury and this effect has been a…