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View article: Safety and effectiveness of lecanemab in Chinese patients with early Alzheimer’s disease: Evidence from a multidimensional real-world study
Safety and effectiveness of lecanemab in Chinese patients with early Alzheimer’s disease: Evidence from a multidimensional real-world study Open
Introduction: Lecanemab has shown promise in treating early Alzheimer’s disease (AD), but its safety and efficacy in Chinese populations remain unexplored. This study aimed to evaluate the safety and 6-month clinical outcomes of lecanemab …
View article: Optimizing the visualization of the locus coeruleus using magnetization transfer contrast 3D imaging
Optimizing the visualization of the locus coeruleus using magnetization transfer contrast 3D imaging Open
The optimized protocol enabled reliable, high-resolution LC imaging in under five minutes, providing a valuable tool for clinical and research applications.
View article: White matter hyperintensity tissue property spatial variations as a function of cognitive status in Parkinson’s disease
White matter hyperintensity tissue property spatial variations as a function of cognitive status in Parkinson’s disease Open
Over and above volume differences, the spatial distribution and tissue property variations of WMH were closely linked to cognitive impairment in PD patients, with distinct patterns across different cognitive stages.
View article: Push-pull effects of basal ganglia network in Parkinson’s disease inferred by functional MRI
Push-pull effects of basal ganglia network in Parkinson’s disease inferred by functional MRI Open
Deep brain stimulation (DBS) can ameliorate motor symptoms in Parkinson's disease (PD), but its mechanism remains unclear. This work constructs a multi-scale brain model using the fMRI data from 27 PD patients with subthalamic DBS and 30 h…
View article: In Vivo visualization of white matter fiber tracts in the brainstem using low flip angle double echo 3D gradient echo imaging at 3T
In Vivo visualization of white matter fiber tracts in the brainstem using low flip angle double echo 3D gradient echo imaging at 3T Open
All the major fiber tracts in the brainstem could be visualized. Given the reasonably short scan time of 10 min at 3T, double echo PDW GRE sequence is a very practical approach for clinical adoption.
View article: Distinct patterns of electrophysiologic-neuroimaging correlations between Parkinson's disease and multiple system atrophy
Distinct patterns of electrophysiologic-neuroimaging correlations between Parkinson's disease and multiple system atrophy Open
Due to a high degree of symptom overlap in the early stages, with movement disorders predominating, Parkinson's disease (PD) and multiple system atrophy (MSA) may exhibit a similar decline in motor areas, yet they differ in their spread th…
View article: Push-pull effects of basal ganglia network in Parkinson’s disease inferred by functional MRI
Push-pull effects of basal ganglia network in Parkinson’s disease inferred by functional MRI Open
Deep brain stimulation (DBS) has the potential to ameliorate the motor symptoms associated with Parkinson’s disease, such as bradykinesia, rigidity, and tremor. However, the precise therapeutic mechanism underlying DBS in Parkinson’s disea…
View article: PENCIL imaging: A novel approach for neuromelanin sensitive MRI in Parkinson's disease
PENCIL imaging: A novel approach for neuromelanin sensitive MRI in Parkinson's disease Open
PENCIL imaging provided improved CNR compared to MTC and showed similar diagnostic performance for differentiating PD subjects from HCs. The major advantage is PENCIL has rapid whole-brain coverage and, when using STAGE imaging, offers a o…
View article: An automatic interpretable deep learning pipeline for accurate Parkinson's disease diagnosis using quantitative susceptibility mapping and <scp>T1‐weighted images</scp>
An automatic interpretable deep learning pipeline for accurate Parkinson's disease diagnosis using quantitative susceptibility mapping and <span>T1‐weighted images</span> Open
Parkinson's disease (PD) diagnosis based on magnetic resonance imaging (MRI) is still challenging clinically. Quantitative susceptibility maps (QSM) can potentially provide underlying pathophysiological information by detecting the iron di…
View article: Subthalamic stimulation modulates motor network in Parkinson’s disease: recover, relieve and remodel
Subthalamic stimulation modulates motor network in Parkinson’s disease: recover, relieve and remodel Open
Aberrant dynamic switches between internal brain states are believed to underlie motor dysfunction in Parkinson’s disease. Deep brain stimulation of the subthalamic nucleus is a well-established treatment for the motor symptoms of Parkinso…
View article: Locus coeruleus and substantia nigra neuromelanin magnetic resonance imaging differentiates Parkinson’s disease and essential tremor
Locus coeruleus and substantia nigra neuromelanin magnetic resonance imaging differentiates Parkinson’s disease and essential tremor Open
The NM volume and contrast measures of the SN and contrast for the LC provided a new perspective on the differential diagnosis of PDTD and ET, and the investigation of the underlying pathophysiology.
View article: Diagnosing Parkinson's disease by combining neuromelanin and iron imaging features using an automated midbrain template approach
Diagnosing Parkinson's disease by combining neuromelanin and iron imaging features using an automated midbrain template approach Open
In summary, this fully automatic template based deep gray matter mapping approach performs well in the segmentation of the SN and its subregions for not only HCs but also PD patients with SN degeneration. The combination of the N1 sign wit…
View article: Visualizing the deep cerebellar nuclei using quantitative susceptibility mapping: An application in healthy controls, Parkinson's disease patients and essential tremor patients
Visualizing the deep cerebellar nuclei using quantitative susceptibility mapping: An application in healthy controls, Parkinson's disease patients and essential tremor patients Open
The visualization and identification of the deep cerebellar nuclei (DCN) (dentate [DN], interposed [IN] and fastigial nuclei [FN]) are particularly challenging. We aimed to visualize the DCN using quantitative susceptibility mapping (QSM),…
View article: Application of Neuromelanin <scp>MR</scp> Imaging in Parkinson Disease
Application of Neuromelanin <span>MR</span> Imaging in Parkinson Disease Open
MRI has been used to develop biomarkers for movement disorders such as Parkinson disease (PD) and other neurodegenerative disorders with parkinsonism such as progressive supranuclear palsy and multiple system atrophy. One of these imaging …
View article: Value of functional connectivity in outcome prediction for pallidal stimulation in Parkinson disease
Value of functional connectivity in outcome prediction for pallidal stimulation in Parkinson disease Open
OBJECTIVE Functional connectivity shows the ability to predict the outcome of subthalamic nucleus deep brain stimulation (DBS) in Parkinson disease (PD). However, evidence supporting its value in predicting the outcome of globus pallidus i…
View article: Alterations in brain iron deposition with progression of late-life depression measured by magnetic resonance imaging (MRI)-based quantitative susceptibility mapping
Alterations in brain iron deposition with progression of late-life depression measured by magnetic resonance imaging (MRI)-based quantitative susceptibility mapping Open
Our study identified brain areas where iron deposition changed with the progression of depression while on antidepressants. The linear relationship of changes in the magnetic susceptibility values in the mPFC, dACC, and some subcortical ar…
View article: Subthalamic and pallidal stimulation in Parkinson's disease induce distinct brain topological reconstruction
Subthalamic and pallidal stimulation in Parkinson's disease induce distinct brain topological reconstruction Open
The subthalamic nucleus (STN) and globus pallidus internus (GPi) are the two most common and effective target brain areas for deep brain stimulation (DBS) treatment of advanced Parkinson's disease. Although DBS has been shown to restore fu…
View article: Mapping Motor Pathways in Parkinson’s Disease Patients with Subthalamic Deep Brain Stimulator: A Diffusion MRI Tractography Study
Mapping Motor Pathways in Parkinson’s Disease Patients with Subthalamic Deep Brain Stimulator: A Diffusion MRI Tractography Study Open
DTI scanning is safe and delineation of white matter pathway is feasible for PD patients implanted with the DBS device. Postoperative DTI is a useful technique to strengthen our current understanding of the therapeutic effect of DBS for PD…
View article: Automatic detection of neuromelanin and iron in the midbrain nuclei using a <scp>magnetic resonance imaging</scp>‐based brain template
Automatic detection of neuromelanin and iron in the midbrain nuclei using a <span>magnetic resonance imaging</span>‐based brain template Open
Parkinson disease (PD) is a chronic progressive neurodegenerative disorder characterized pathologically by early loss of neuromelanin (NM) in the substantia nigra pars compacta (SNpc) and increased iron deposition in the substantia nigra (…
View article: Stability of AI-Enabled Diagnosis of Parkinson’s Disease: A Study Targeting Substantia Nigra in Quantitative Susceptibility Mapping Imaging
Stability of AI-Enabled Diagnosis of Parkinson’s Disease: A Study Targeting Substantia Nigra in Quantitative Susceptibility Mapping Imaging Open
Purpose: Parkinson’s disease (PD) diagnosis algorithms based on quantitative susceptibility mapping (QSM) and image algorithms rely on substantia nigra (SN) labeling. However, the difference between SN labels from different experts (or seg…
View article: Predicting Motor Outcome of Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s Disease Using Quantitative Susceptibility Mapping and Radiomics: A Pilot Study
Predicting Motor Outcome of Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s Disease Using Quantitative Susceptibility Mapping and Radiomics: A Pilot Study Open
Background Emerging evidence indicates that iron distribution is heterogeneous within the substantia nigra (SN) and it may reflect patient-specific trait of Parkinson’s Disease (PD). We assume it could account for variability in motor outc…
View article: Subthalamic and Pallidal Stimulations in Patients with Parkinson's Disease: Common and Dissociable Connections
Subthalamic and Pallidal Stimulations in Patients with Parkinson's Disease: Common and Dissociable Connections Open
Objective The subthalamic nucleus (STN) and internal globus pallidus (GPi) are the most effective targets in deep brain stimulation (DBS) for Parkinson's disease (PD). However, the common and specific effects on brain connectivity of stimu…
View article: Editorial: Quantitative Susceptibility Mapping in Neurodegeneration
Editorial: Quantitative Susceptibility Mapping in Neurodegeneration Open
EDITORIAL article Front. Neurosci., 22 July 2021Sec. Neurodegeneration https://doi.org/10.3389/fnins.2021.724550
View article: Reversal of Functional Brain Activity Related to Gut Microbiome and Hormones After VSG Surgery in Patients With Obesity
Reversal of Functional Brain Activity Related to Gut Microbiome and Hormones After VSG Surgery in Patients With Obesity Open
Context Vertical sleeve gastrectomy (VSG) is becoming a prioritized surgical intervention for obese individuals; however, the brain circuits that mediate its effective control of food intake and predict surgical outcome remain largely uncl…
View article: Iron Content in Deep Gray Matter as a Function of Age Using Quantitative Susceptibility Mapping: A Multicenter Study
Iron Content in Deep Gray Matter as a Function of Age Using Quantitative Susceptibility Mapping: A Multicenter Study Open
Purpose To evaluate the effect of resolution on iron content using quantitative susceptibility mapping (QSM); to verify the consistency of QSM across field strengths and manufacturers in evaluating the iron content of deep gray matter (DGM…
View article: Susceptibility and Volume Measures of the Mammillary Bodies Between Mild Cognitively Impaired Patients and Healthy Controls
Susceptibility and Volume Measures of the Mammillary Bodies Between Mild Cognitively Impaired Patients and Healthy Controls Open
This work provides a quantitative baseline for both the volume and susceptibility of the mammillary body which can be used for future studies of cognitive impairment patients underlying the pathology of the Papez circuit.