Explanipedia

Risk-free radiation exposure during pregnancy - Review Open

Muskan Khan, Nazema Y. Siddiqui, Mohnish Muchhal, Kanneboyina Nagaraju · 2025

For a mother, the maternal phase is a wonderful time period. Any carelessness can have negative effects on hormonal balance, and dental neglect can cause alterations during pregnancy and have an impact on the developing fetus throughout or…

A negative binomial latent factor model for paired microbiome sequencing data Open

Hyotae Kim, Nazema Y. Siddiqui, Lisa Karstens, Li Ma · 2024

Motivation Microbiome compositional data are often collected from several body sites and exhibit dependency among them. Analyzing microbial compositions from different sites jointly allows for effective borrowing of information by exploiti…

Apical Suspension Repair for Vaginal Vault Prolapse Open

Shawn A. Menefee, Holly E. Richter, Deborah L. Myers, Pamela Moalli, Alison C. Weidner , et al. · 2024

Importance The optimal surgical repair of vaginal vault prolapse after hysterectomy remains undetermined. Objective To compare the efficacy and safety of 3 surgical approaches for vaginal vault prolapse after hysterectomy. Design, Setting,…

Commensal bacteria inhibit viral infections via a tryptophan metabolite Open

Danting Jiang, Nicole Soo, Chin Yee Tan, Sedem Dankwa, Hsuan-Yuan Wang , et al. · 2024

SUMMARY Clinical outcomes following viral exposures exhibit substantial interindividual variability. Although developing evidence suggests commensal bacteria modulate viral infections, the specific bacteria and mechanisms remain underexplo…

Proposing the “Continuum of UTI” for a Nuanced Approach to Diagnosis and Management of Urinary Tract Infections Open

Sonali D. Advani, Nicholas Turner, Rebecca North, Rebekah W. Moehring, Valerie M. Vaughn , et al. · 2024

Our data suggest the need to reframe our conceptual model of UTI vs ASB to reflect the full spectrum of clinical presentations, acknowledge the diagnostic uncertainty faced by frontline clinicians, and promote a nuanced approach to diagnos…

Urinary microbiome community types associated with urinary incontinence severity in women Open

Megan U. Carnes, Nazema Y. Siddiqui, Lisa Karstens, Marie G. Gantz, Darrell L. Dinwiddie , et al. · 2023

Draft genomes of <i>Lactobacillus delbrueckii</i> and <i>Klebsiella pneumoniae</i> coexisting within a female urinary bladder Open

Laricca Y. London, Chae Hee Lim, Jennifer L. Modliszewski, Nazema Y. Siddiqui, Tatyana A. Sysoeva · 2023

Here, we present the draft genome sequences of Lactobacillus delbrueckii and Klebsiella pneumoniae , both isolated from the urinary bladder of an asymptomatic post-menopausal female patient with a diagnosis of recurrent urinary tract infec…

Focal Segmental Glomerulosclerosis: Assessing the Risk of Relapse Open

Stéphan Troyanov, Arenn Jauhal, Heather N. Reich, Michelle Hladunewich, Daniel C. Cattran , et al. · 2023

In FSGS, relapses are frequent but predictable using independent clinical characteristics. We also provide evidence that atypical presentations remit and relapse following the same pattern as classic FSGS presentations. Treatment strategie…

Proposing the “continuum of UTI” for a nuanced approach to antimicrobial stewardship Open

Sonali D. Advani, Nicholas Turner, Rebecca North, Rebekah W. Moehring, Alicia Nelson , et al. · 2023

Background: Historically, diagnosis of urinary tract infections (UTIs) has been divided into 3 categories based on symptoms and urine culture results: not UTI, asymptomatic bacteriuria (ASB), or UTI. However, some populations (eg, older ad…

Standard Restrictions vs Expedited Activity After Pelvic Organ Prolapse Surgery Open

Michele O’Shea, Nazema Y. Siddiqui, Tracy Truong, Alaattin Erkanli, Matthew D. Barber · 2023

Importance Restrictions on postoperative activity following pelvic organ prolapse (POP) surgery are not evidence based. Nonetheless, many pelvic surgeons place lifting and activity restrictions on patients following surgery. Objective To e…

Quantifying the benefits of remission duration in focal and segmental glomerulosclerosis Open

Arenn Jauhal, Heather N. Reich, Michelle Hladunewich, Moumita Barua, Bettina E. Hansen , et al. · 2022

Background Although the clinical benefit of obtaining a remission in proteinuria in nephrotic patients with focal segmental glomerulosclerosis (FSGS) is recognized, the long-term value of maintaining it and the impact of relapses on outcom…

Updating Urinary Microbiome Analyses to Enhance Biologic Interpretation Open

Nazema Y. Siddiqui, Li Ma, Linda Brubaker, Jialiang Mao, Carter Hoffman , et al. · 2022

Objective An approach for assessing the urinary microbiome is 16S rRNA gene sequencing, where analysis methods are rapidly evolving. This re-analysis of an existing dataset aimed to determine whether updated bioinformatic and statistical t…

Concordance of urinary microbiota detected by 16S ribosomal RNA amplicon sequencing vs expanded quantitative urine culture Open

Monique H. Vaughan, Gregory Zemtsov, Erin M. Dahl, Lisa Karstens, Li Ma , et al. · 2022

Commensal Urinary Lactobacilli Inhibit Major Uropathogens In Vitro With Heterogeneity at Species and Strain Level Open

James A. Johnson, Lydia F. Delaney, Vaishali Ojha, Medha Rudraraju, Kaylie R. Hintze , et al. · 2022

The human urinary microbiome is thought to affect the development and progression of urinary tract infections (UTI), particularly recurrent UTIs in aging populations of women. To understand the possible interactions of urinary pathogens wi…

AUGS-PERFORM: A New Patient-Reported Outcome Measure to Assess Quality of Prolapse Care Open

Michele O’Shea, Sarah Hamilton Boyles, Catherine S. Bradley, Kristin M. Jacobs, Molly McFatrich , et al. · 2022

Objective Patient-reported outcomes (PRO) are important for measuring quality of care, particularly for interventions aimed at improving symptom bother such as procedures for pelvic organ prolapse. We aimed to create a concise yet comprehe…

Updating urinary microbiome analyses to enhance biologic interpretation Open

Nazema Y. Siddiqui, Li Ma, Linda Brubaker, Jialiang Mao, Carter Hoffman , et al. · 2021

Objective An approach for assessing the urinary microbiome is 16S rRNA gene sequencing, where a segment of the bacterial genome is amplified and sequenced. Methods used to analyze these data are rapidly evolving, although the research impl…

Association between the urogenital microbiome and surgical treatment response in women undergoing midurethral sling operation for mixed urinary incontinence Open

Holly E. Richter, Megan U. Carnes, Yuko M. Komesu, Emily S. Lukacz, Lily A. Arya , et al. · 2021

The Urinary Microbiome in Postmenopausal Women with Recurrent Urinary Tract Infections Open

Monique H. Vaughan, Jialiang Mao, Lisa A. Karstens, Li Ma, Cindy L. Amundsen , et al. · 2021

Associations between anaerobes within the urinary microbiome and postmenopausal recurrent UTI warrants further investigation.

Defining mechanisms of recurrence following apical prolapse repair based on imaging criteria Open

Shaniel T. Bowen, Pamela Moalli, Steven D. Abramowitch, Mark E. Lockhart, Alison C. Weidner , et al. · 2021

The Urinary Microbiome in Postmenopausal Women with Recurrent Urinary Tract Infections Open

Monique H. Vaughan, Jialiang Mao, Lisa A. Karstens, Li Ma, Cindy L. Amundsen , et al. · 2020

Recurrent urinary tract infections (UTI) are highly prevalent in postmenopausal women, where vaginal estrogen and prophylactic antibiotics are used for treatment. The etiology of recurrent UTIs is not completely known, but the urinary micr…

Benchmarking DNA isolation kits used in analyses of the urinary microbiome Open

Lisa Karstens, Nazema Y. Siddiqui, Tamara Zaza, Alecsander Barstad, Cindy L. Amundsen , et al. · 2020

The urinary microbiome has been increasingly characterized using next-generation sequencing. However, many of the technical methods have not yet been specifically optimized for urine. We sought to compare the performance of several DNA iso…

Species level resolution of female bladder microbiota from 16S rRNA amplicon sequencing Open

Carter Hoffman, Nazema Y. Siddiqui, Ian Fields, W. Thomas Gregory, Holly M. Simon , et al. · 2020

The human bladder contains bacteria in the absence of infection. Interest in studying these bacteria and their association with bladder conditions is increasing. However, the chosen experimental method can limit the resolution of the taxon…

Table of Contents Open

Roberto Romero, Riccardo Inchingolo, Andrea Smargiassi, F. Moro, Danilo Buonsenso , et al. · 2020

Deciding Our Future: Consensus Conference Summary Report Open

Nazema Y. Siddiqui, Gena C. Dunivan, Christopher Chermansky, Catherine S. Bradley · 2020

Objectives There are few quality measures that allow for optimization of care for pelvic organ prolapse (POP). In coordination with the American Urogynecologic Society (AUGS), a prior group agreed upon health care provider–reported data el…

Accidental Bowel Leakage Evaluation: A New Patient-Centered Validated Measure of Accidental Bowel Leakage Symptoms in Women Open

Rebecca G. Rogers, Vivian W. Sung, Emily S. Lukacz, Pamela S. Fairchild, Lily A. Arya , et al. · 2020

BACKGROUND: Questionnaires assessing accidental bowel leakage lack important patient-centered symptoms. OBJECTIVE: We aimed to create a valid measure of accidental bowel leakage symptoms. DESIGN: We previously created a conceptual framewor…

A comparison of antibiotic prophylaxis regimens to decrease the risk of post-procedure urinary tract infection after onabotulinum toxin A injection Open

Jennifer A. Bickhaus, Monique H. Vaughan, Tracy Truong, Yi‐Ju Li, Nazema Y. Siddiqui · 2020

Defining the relationship between vaginal and urinary microbiomes Open

Yuko M. Komesu, Darrell L. Dinwiddie, Holly E. Richter, Emily S. Lukacz, Vivian W. Sung , et al. · 2019

Does a Recent Urinary Tract Infection Increase the Risk of Postprocedure Urinary Tract Infection After Onabotulinum Toxin A? Open

Jennifer A. Bickhaus, Megan S. Bradley, Cindy L. Amundsen, Anthony G. Visco, Tracy Truong , et al. · 2019

Objectives The objective of this study was to evaluate the risk of postprocedure urinary tract infection (UTI) after injection of onabotulinum toxin A (BTX-A) in women who had a UTI within 30 days before procedure. Methods This was a retro…

Table of Contents Open

Naeem Bhojani, Mohamed Bidair, Kevin C. Zorn, Andrew Trainer, Andrew Arther , et al. · 2019

Biomarkers Implicated in Lower Urinary Tract Symptoms: Systematic Review and Pathway Analyses Open

Nazema Y. Siddiqui, Brian T. Helfand, Victor P. Andreev, Joseph T. Kowalski, Megan S. Bradley , et al. · 2019

Major deficiencies in the existing biomarker literature include poor reproducibility of laboratory data, unclear classification of patients with lower urinary tract symptoms and lack of adjustment for clinical covariates. Despite these lim…

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