Explanipedia

International Expert Consensus on Defining Skin of Color and Delivering Equitable Dermatologic Care Open

Henry W. Lim, Chengfeng Zhang, Marisa Taylor, Ncoza C. Dlova, Katleen Conceição , et al. · 2025

Dermatological practice faces significant challenges in meeting the needs of populations with skin of color (SOC). Patients with SOC face disparities, including misdiagnoses and inequitable treatment outcomes. This expert consensus sought …

The Development of a Global Health Dermatologic Surgery Training Program in Durban, South Africa: A Cohort Study Open

Vishal Patel, Myra A. Zaheer, Matthew Liu, Muhammed Peer, Anisa Mosam , et al. · 2025

The neglected majority: Inverse relationship between prevalence and global research activity of 15 dermatological diseases Open

Oliver Brandt, Erere Otrofanowei, Ncoza C. Dlova, Simon M. Mueller · 2025

Authorship dynamics: a bibliometric analysis of low- and middle-income country author representation in high-impact dermatology journals Open

Jadesola Akinwuntan, Christine Li, S. K. Jain, Sonya Prasad, Doriane Sabushimike , et al. · 2025

This study analysed authorship trends in high-impact dermatology journals and dermatological content in journals based in low- and middle-income countries (LMIC) from 2018 to 2023. It found that only 12.2% of publications in high-impact de…

Skin disease in the Eastern Cape (SKINSCAPE): a Global Psoriasis Atlas point prevalence study in rural South Africa Open

Alison K. Wright, Rebekah Swan, Jingyuan Xu, Su M. Lwin, Shir Azrielant , et al. · 2025

Background The Eastern Cape is an under-resourced province and the poorest in South Africa, where little is known about the epidemiology of skin diseases. Objectives To examine the nature and prevalence of skin diseases in two neighbouring…

Beyond the Skin Surface: Melanocyte Biology and the Spectrum of Health Inequities Open

Attiya A. Abbas, Ncoza C. Dlova, Claire A. Higgins · 2025

A striking physiological variance between human beings is the color of their skin, which is evident across human populations. Skin color is determined by the amount of eumelanin, a subtype of the pigment melanin in the skin, with higher le…

Consensus statements for the transdisciplinary care of patients with epidermolysis bullosa in South Africa: Part 1 Open

Antoinette Chateau, Carol Hlela, Ncoza C. Dlova, Thuraya Isaacs, Thirona Naicker , et al. · 2025

Background: Epidermolysis bullosa (EB) is a rare, painful and blistering genodermatosis with no cure. Treatment aims to prevent new lesions and manage complications. Previously, there were no management guidelines or consensus recommendati…

Statement from the frontal fibrosing alopecia international expert alliance: <span>SOFFIA</span> 2024 Open

Nekma Meah, Jane Li, Dmitri Wall, Katherine York, Bevin Bhoyrul , et al. · 2025

Background As the incidence of frontal fibrosing alopecia (FFA) continues to rise, there is a need for an optimal treatment algorithm for FFA. Objective To produce an international consensus statement on the treatment modalities and progno…

Chemical Peels for Skin Rejuvenation and Anti-Aging in Darker Skin Tones Open

Nomakhosi Mpofana, Banathi Sihonqo, Mokgadi Ursula Makgobole, Celenkosini Thembelenkosini Nxumalo, Ncoza C. Dlova · 2025

Chemical peels are a popular skin care treatment that improves skin texture and a variety of skin concerns, including hyperpigmentation, acne scars, and signs of aging. While they can be effective for people with darker skin, their use req…

The effects and safety of sequential high concentration glycolic acid and trichloroacetic acid chemical peels in skin photo-type IV–VI, a retrospective cross-sectional monocentric review Open

Frans Maruma, Ncoza C. Dlova, Thabiso Rafaki Petrus Mofokeng, Edward Ngwenya · 2025

Background: Melasma is a common chronic form of cutaneous hyperpigmentation, particularly prevalent in individuals with Fitzpatrick skin phototypes IV–VI, and it predominantly affects the facial areas of women. The patients with melasma of…

The Importance of Shared Patient Voices in Advancing Science for Genodermatoses on a Global Scale Open

Fauve C A P van Veen, Eli Sprecher, Janice Schwartz, Tom Baker, Edel A. O’Toole , et al. · 2025

The essential role of dermatology publications in enhancing professional diversity, equity and inclusion Open

Susan Burgin, Ncoza C. Dlova, John R Ingram, Lawrence Charles Parish, Lowell A. Goldsmith · 2025

Dermatology publications have substantial untapped potential to improve patient care for all patients and communities. The leadership role of both the editors and editorial boards of these journals, books and digital media provides an impo…

COLLAB: A Global Survey of Clinical and Laboratory Assessment in Alopecia Areata by Hair Specialists Open

Cathal O’Connor, Aoife Boyle, Leila Asfour, Bevin Bhoyrul, Laita Bokhari , et al. · 2025

Background Alopecia areata (AA) is a common non‐scarring alopecia. Data continue to emerge on associations with autoimmune and other conditions. Janus kinase inhibitors (JAKi) are increasingly used to treat AA. Objectives The aim was to as…

The Spectrum of Epidermolysis Bullosa in KwaZulu‐Natal, South Africa Open

Antoinette Chateau, Thirona Naicker, Cassandra Bruce‐Brand, J Schneider, Colleen Aldous , et al. · 2025

Background Epidermolysis bullosa (EB) is a rare, heterogeneous genodermatosis characterized by skin fragility due to inherited defects in genes encoding proteins that maintain epidermal–dermal integrity. The severity and complications of E…

Anti-Tyrosinase and Radical Scavenging Activities of Selected Cassipourea Plants and Isolated 7-Methoxygeranin A: Traditional Use as Skin Lighteners Open

Nomakhosi Mpofana, Michael Paulse, Masande Yalo, Ncoza C. Dlova, Ahmed A. Hussein , et al. · 2025

While C. flanaganii demonstrated the strongest anti-tyrosinase activity, C. gummiflua showed the highest antioxidant potential. Emodin 6,8-dimethyl ether emerged as a promising candidate for skin-lightening applications, warranting …

Effective Reduction of Acne-induced Post-inflammatory Hyperpigmentation with the Human Tyrosinase Inhibitor Thiamidol (isobutylamido thiazolyl resorcinol) Open

Dennis Roggenkamp, Ncoza C. Dlova, Tobias Mann, Jan Batzer, Julia Riedel , et al. · 2025

Objective: Post-inflammatory hyperpigmentation (PIH) is a major cosmetic concern especially in individuals with darker skin complexion. Unfortunately, treatment with anti-inflammatory ingredients alone does not prevent the development of h…

Association of Genetic Polymorphisms in SLC45A2, TYR, HERC2, and SLC24A in African Women with Melasma: A Pilot Study Open

Nomakhosi Mpofana, Zinhle Pretty Mlambo, Mokgadi Ursula Makgobole, Ncoza C. Dlova, Thajasvarie Naicker · 2025

Melasma is a chronic skin disorder characterized by hyperpigmentation, predominantly affecting women with darker skin types, including those of African descent. This study investigates the association between genetic variants in SLC45A2, T…

Nevus of Hori in African patients: an entity that is most likely underdiagnosed in clinical practice Open

Frans Maruma, Ncoza C. Dlova, Thabiso Rafaki Petrus Mofokeng, Boitshoko Claudia Moloabi · 2025

Background: Nevus of Hori (HN) has been primarily reported in patients of Eastern Asian descent, with a paucity of data regarding HN occurring in African patients. In this study, we report on South African patients with HN initially though…

Consensus statements for the biopsychosocial care of patients with epidermolysis bullosa South Africa: Part 2. Open

Antoinette Chateau, David Blackbeard, Carol Hlela, Martie Wege, Andrew Wreford Armour , et al. · 2025

This is the first set of consensus statements for the care of EB in South Africa and the broader African continent, offering a culturally sensitive, patient-centred framework for multidisciplinary care.

Association of SLC45A2 (rs11568737, rs28777); TYR (rs1042602, rs1126809); HERC2 (rs1129038) and SLC24A (rs1426654) Single Nucleotide Polymorphisms with Melasma in African Women – A Pilot Study Open

Nomakhosi Mpofana, Zinhle Pretty Mlambo, Mokgadi Ursula Makgobole, Ncoza C. Dlova, Thajasvarie Naicker · 2024

Melasma is a chronic skin disorder characterized by hypermelanosis, predominantly affecting women of African descent. This study explores the association between genetic variants of the genes SLC45A2, TYR, HERC2, and SLC24A and the severit…

Lived experiences of patients with epidermolysis bullosa: A rare genetic skin disease Open

Antoinette Chateau, David Blackbeard, Colleen Aldous, Ncoza C. Dlova, Cassidy-Mae Shaw · 2024

Background: Epidermolysis bullosa (EB) is a rare genodermatosis that results in extreme skin fragility, for which there is no cure and may be fatal. The quality of life of patients affected may be greatly impacted.Aim: This study aims to u…

Treatment Outcomes for Dermatosis Papulosa Nigra Using Low‐Intensity Electrodesiccation Device in African Patients Open

Frans Maruma, Ncoza C. Dlova, Thabiso Rafaki Petrus Mofokeng, Firas Al‐Niaimi · 2024

Objective We aimed to document the treatment outcomes of African patients treated with low‐intensity electrodesiccation for DPN's. Other treatment options for DPN's include snip excision, light curettage, cryotherapy, and lasers devices su…

Mechanisms of Selected Cassipourea Metabolites for Melasma Treatment: Network Pharmacology and Molecular Dynamics Study Open

Nomakhosi Mpofana, Christina Peter, Halimat Yusuf Lukman, Mokgadi Ursula Makgobole, Ncoza C. Dlova , et al. · 2024

Background Melasma is a common dyschromia, mainly found in women with darker skin types. Although asymptomatic, melasma significantly impacts patients’ quality of life. Due to this complex pathogenesis, melasma is difficult to treat. Plan…

Corrigendum: The impact, perceptions and needs of parents of children with epidermolysis bullosa Open

Antoinette Chateau, David Blackbeard, Colleen Aldous, Ncoza C. Dlova, Cassidy-Mae Shaw · 2024

No abstract available.

The impact, perceptions and needs of parents of children with epidermolysis bullosa Open

Antoinette Chateau, David Blackbeard, Colleen Aldous, Ncoza C. Dlova, Cassidy-Mae Shaw · 2024

Parents caring for children with EB face emotional, physical, psychosocial and financial challenges. Addressing parents' needs and concerns will go a long way in decreasing this burden. A biopsychosocial approach with an awareness of cultu…

Characteristics, clinical manifestations and management of leprosy in KwaZulu-Natal, South Africa: A 20-year retrospective study Open

Jacob S. Sons, Zamambo Mkhize, Ncoza C. Dlova, Colleen Aldous, RameshM Bhat , et al. · 2024

Background. Although leprosy, a neglected tropical disease, has been eliminated (<1 case per 10 000 population) in South Africa (SA) since 1926, according to the World Health Organization, new cases continue to be reported. The management …

Inclusive and equitable language for skin colour in the <i>British Journal of Dermatology</i>: acknowledging our past and laying the foundations to move forward Open

Linda Oyesiku, Ncoza C. Dlova, Shehnaz Ahmed, David Owen, John R Ingram , et al. · 2024

The field of dermatology must recognize that the language we use to describe skin colour has been profoundly affected by misconstruction and misattribution of skin colour naming with human group names, phenotype, phototype and Western raci…

Predicting the evolution of clinical skin aging in a multi‐ethnic population: Developing causal Bayesian networks using dermatological expertise Open

Hussein Jouni, Lionel Jouffe, Emmanuelle Tancrède‐Bohin, P André, Soraya Benamor , et al. · 2024

Introduction Software to predict the impact of aging on physical appearance is increasingly popular. But it does not consider the complex interplay of factors that contribute to skin aging. Objectives To predict the +15‐year progression of…

Back Cover Open

Hussein Jouni, Lionel Jouffe, Emmanuelle Tancrède‐Bohin, P André, Soraya Benamor , et al. · 2024

The cover image is based on the Original Article Predicting the evolution of clinical skin aging in a multi‐ethnic population: Developing causal Bayesian networks using dermatological expertise by Hussein Jouni et al., https://doi.org/10.1…

Analysis of Three Species of Cassipourea Traditionally Used for Hypermelanosis in Selected Provinces in South Africa Open

Nomakhosi Mpofana, Masande Yalo, Nceba Gqaleni, Ncoza C. Dlova, Ahmed A. Hussein · 2023

There is a growing demand and use of herbal cosmetics for skin purposes due to their perceived safety when applied to the skin. Three Cassipourea species commonly known as “ummemezi” are used interchangeably by women in rural areas of East…

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