Neal I. Callaghan
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View article: Letter of Intent: The Forward Physics Facility
Letter of Intent: The Forward Physics Facility Open
The Forward Physics Facility (FPF) is a proposed extension of the HL-LHC program designed to exploit the unique scientific opportunities offered by the intense flux of high energy neutrinos, and possibly new particles, in the far-forward d…
View article: Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes Open
Phagocytes are essential for orchestrating both short‐ and long‐term immune responses by internalizing extracellular material to clear pathogens, resolve tissue damage, present antigens, and secrete regulatory cytokines. In chronic inflamm…
View article: Cellular crosstalk in fibrosis: Insights into macrophage and fibroblast dynamics
Cellular crosstalk in fibrosis: Insights into macrophage and fibroblast dynamics Open
View article: A Prototype Atom Interferometer to Detect Dark Matter and Gravitational Waves
A Prototype Atom Interferometer to Detect Dark Matter and Gravitational Waves Open
The AION project has built a tabletop prototype of a single-photon long-baseline atom interferometer using the 87Sr clock transition - a type of quantum sensor designed to search for dark matter and gravitational waves. Our prototype detec…
View article: Development of Itaconate Polymers Microparticles for Intracellular Regulation of Pro‐Inflammatory Macrophage Activation
Development of Itaconate Polymers Microparticles for Intracellular Regulation of Pro‐Inflammatory Macrophage Activation Open
Itaconate (IA) is an endogenous metabolite and a potent regulator of the innate immune system. It's use in immunomodulatory therapies has faced limitations due to challenges in controlled delivery and requirements of high extracellular con…
View article: Persistent glycolysis defines the foreign body response to polymeric implants
Persistent glycolysis defines the foreign body response to polymeric implants Open
Non-degradable polymeric implantable medical devices are a mainstay of modern healthcare but can frequently lead to severe complications. These complications are largely attributable to the foreign body response ( FBR ), which is character…
View article: Development of itaconate polymer microparticles for intracellular regulation of pro-inflammatory macrophage activation
Development of itaconate polymer microparticles for intracellular regulation of pro-inflammatory macrophage activation Open
Itaconate (IA) is an endogenous metabolite and a potent regulator of the innate immune system. Its use in immunomodulatory therapies has faced limitations due to inherent challenges in achieving controlled delivery and requirements for hig…
View article: Excitation–contraction coupling reflects the metabolic profile of mantle muscle in young cuttlefish (<scp><i>Sepia officinalis</i></scp>)
Excitation–contraction coupling reflects the metabolic profile of mantle muscle in young cuttlefish (<span><i>Sepia officinalis</i></span>) Open
The mantle muscle of common cuttlefish, Sepia officinalis , is responsible both for high‐magnitude and rapid movements for locomotion, as well as sustained ventilation, which require specific metabolic, electrophysiological, and structural…
View article: Process Mining Uncovers Actionable Patterns of Red Blood Cell Unit Wastage in a Health Care Network
Process Mining Uncovers Actionable Patterns of Red Blood Cell Unit Wastage in a Health Care Network Open
Packed red blood cell transfusions are integral to the care of the critically and chronically ill patient, but require careful storage and a large, coordinated network to ensure their integrity during distribution and administration. Audit…
View article: Discovery: Transition of an Inquiry-focused Learning Program to a Virtual Platform During the COVID-19 Pandemic (Evaluation)
Discovery: Transition of an Inquiry-focused Learning Program to a Virtual Platform During the COVID-19 Pandemic (Evaluation) Open
The shift to distance learning in response to the COVID-19 pandemic has presented teachers and students with several challenges. Teachers have found themselves quickly creating distance learning materials to provide equal or greater educat…
View article: Cell dynamics and metabolism of the foreign body response: characterizing host-biomaterial interactions for next-generation medical implant biocompatibility
Cell dynamics and metabolism of the foreign body response: characterizing host-biomaterial interactions for next-generation medical implant biocompatibility Open
Profiling cellular metabolism in the FBR could identify novel therapeutic targets and promote biocompatibility.
View article: Noninvasive Quantification of Contractile Dynamics in Cardiac Cells, Spheroids, and Organs-on-a-Chip Using High-Frequency Ultrasound
Noninvasive Quantification of Contractile Dynamics in Cardiac Cells, Spheroids, and Organs-on-a-Chip Using High-Frequency Ultrasound Open
Cell-based models that mimic in vivo heart physiology are poised to make significant advances in cardiac disease modeling and drug discovery. In these systems, cardiomyocyte (CM) contractility is an important functional metric, but current…
View article: Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts
Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts Open
View article: Advanced physiological maturation of iPSC-derived human cardiomyocytes using an algorithm-directed optimization of defined media components
Advanced physiological maturation of iPSC-derived human cardiomyocytes using an algorithm-directed optimization of defined media components Open
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) hold tremendous promise for in vitro modeling to assess native myocardial function and disease mechanisms as well as testing drug safety and efficacy. However, current iPSC- C…
View article: Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissues
Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissues Open
View article: Non-invasive quantification of contractile dynamics in cardiac cells, spheroids and organs-on-a-chip using high frequency ultrasound
Non-invasive quantification of contractile dynamics in cardiac cells, spheroids and organs-on-a-chip using high frequency ultrasound Open
Cell-based models that mimic in vivo heart physiology are poised to make significant advances in cardiac disease modeling and drug discovery. In these systems, cardiomyocyte (CM) contractility is an important functional metric, but current…
View article: Enhancing senior high school student engagement and academic performance using an inclusive and scalable inquiry-based program
Enhancing senior high school student engagement and academic performance using an inclusive and scalable inquiry-based program Open
View article: IBBME Discovery: Biomedical Engineering-based Iterative Learning in a High School STEM Curriculum (Evaluation)
IBBME Discovery: Biomedical Engineering-based Iterative Learning in a High School STEM Curriculum (Evaluation) Open
Senior high school students often struggle with recognizing the link between human health care and engineering, resulting in limited recruitment for post-secondary biomedical engineering (BME) study. To enhance student comprehension and re…
View article: Discovery: Differential Student Impact is Evident Within an Inquiry-focused Secondary/Post-secondary Collaborative STEM Program
Discovery: Differential Student Impact is Evident Within an Inquiry-focused Secondary/Post-secondary Collaborative STEM Program Open
Introduction: Curriculum for high school students who participate in a science, technology, engineering, and math (STEM) are generally focused on delivery of knowledge in effort to ensure achievement of learning outcomes related to importa…
View article: Graduate Student Pedagogical Impact Through Development and Delivery of a Collaborative Inquiry-focused High School STEM Program
Graduate Student Pedagogical Impact Through Development and Delivery of a Collaborative Inquiry-focused High School STEM Program Open
Considering a changing academic landscape that desires skill development beyond that of traditional research, post-secondary STEM students now require broad opportunities to improve their translatable skill set. Notably, we routinely obser…
View article: Discovery: Virtual Implementation of Inquiry-Based Remote Learning for Secondary STEM Students During the COVID-19 Pandemic
Discovery: Virtual Implementation of Inquiry-Based Remote Learning for Secondary STEM Students During the COVID-19 Pandemic Open
View article: EXPANDED CROSS-DISCIPLINE IMPLEMENTATION STRATEGY OF DISCOVERY: A BIOMEDICAL ENGINEERING-THEMED EDUCATION PROGRAM BRIDGING SECONDARY AND POST-SECONDARY LEARNING
EXPANDED CROSS-DISCIPLINE IMPLEMENTATION STRATEGY OF DISCOVERY: A BIOMEDICAL ENGINEERING-THEMED EDUCATION PROGRAM BRIDGING SECONDARY AND POST-SECONDARY LEARNING Open
High school science, technology, engineering, and math (STEM) curricula are generally knowledge-based in methodology and focus on content delivery in preparation for post-secondary study. However, the rapid technological change at the cutt…
View article: Functional culture and in vitro genetic and small-molecule manipulation of adult mouse cardiomyocytes
Functional culture and in vitro genetic and small-molecule manipulation of adult mouse cardiomyocytes Open
Primary adult cardiomyocyte (aCM) represent the mature form of myocytes found in the adult heart. However, culture of aCMs in particular is challenged by poor survival and loss of phenotype, rendering extended in vitro experiments unfeasib…
View article: Enhancing senior high school student engagement and academic performance using an inclusive and scalable inquiry-based program
Enhancing senior high school student engagement and academic performance using an inclusive and scalable inquiry-based program Open
The multi-disciplinary nature of science, technology, engineering and math (STEM) careers often renders difficulty for high school students navigating from classroom knowledge to post-secondary pursuits. Discrepancies between the knowledge…
View article: Interrelationship Between Contractility, Protein Synthesis and Metabolism in Mantle of Juvenile Cuttlefish (Sepia officinalis)
Interrelationship Between Contractility, Protein Synthesis and Metabolism in Mantle of Juvenile Cuttlefish (Sepia officinalis) Open
Young juvenile cuttlefish (Sepia officinalis) can grow at rates as high as 12% body weight per day. How the metabolic demands of such a massive growth rate impacts muscle performance that competes for ATP is unknown. Here, we integr…
View article: Long-term, functional culture and<i>in vitro</i>manipulation of adult mouse cardiomyocytes
Long-term, functional culture and<i>in vitro</i>manipulation of adult mouse cardiomyocytes Open
Primary adult cardiomyocyte (aCM) culture is challenged by poor survival and loss of phenotype, rendering extended in vitro experiments unfeasible. Here, we establish murine aCM culture methods that enhance survival and maintain sarcomeric…
View article: Nanoscale reorganization of sarcoplasmic reticulum in pressure-overload cardiac hypertrophy visualized by dSTORM
Nanoscale reorganization of sarcoplasmic reticulum in pressure-overload cardiac hypertrophy visualized by dSTORM Open
Pathological cardiac hypertrophy is a debilitating condition characterized by deleterious thickening of the myocardium, dysregulated Ca 2+ signaling within cardiomyocytes, and contractile dysfunction. Importantly, the nanoscale organizatio…
View article: Modeling cardiac complexity: Advancements in myocardial models and analytical techniques for physiological investigation and therapeutic development <i>in vitro</i>
Modeling cardiac complexity: Advancements in myocardial models and analytical techniques for physiological investigation and therapeutic development <i>in vitro</i> Open
Cardiomyopathies, heart failure, and arrhythmias or conduction blockages impact millions of patients worldwide and are associated with marked increases in sudden cardiac death, decline in the quality of life, and the induction of secondary…
View article: Age‐dependent effects on sympathetic responsiveness in cardiac action potential conduction and calcium handling
Age‐dependent effects on sympathetic responsiveness in cardiac action potential conduction and calcium handling Open
The ageing heart can be challenged by numerous electrophysiological complications, brought on by fibrotic conductive blockages, ageing cardiomyocytes (CMs) and increased nodal incompetency. The sympathetic nervous system (SNS) has a variet…
View article: Data for: Nanoparticulate-specific effects of silver on teleost cardiac contractility
Data for: Nanoparticulate-specific effects of silver on teleost cardiac contractility Open
Contains TEM images of the nAg used in the study as well as all quantitative data used to make the figures. Please direct all correspondence to: Neal Callaghan Translational Biology and Engineering Program, Ted Rogers Centre for Heart Rese…