Neel Heerasing
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View article: Primary care faecal calprotectin testing in children with suspected inflammatory bowel disease: a diagnostic accuracy study
Primary care faecal calprotectin testing in children with suspected inflammatory bowel disease: a diagnostic accuracy study Open
ObjectiveTo determine the diagnostic accuracy of calprotectin to diagnose inflammatory bowel disease (IBD) in children in whom general practitioners (GPs) suspected IBD.DesignProspective observational cohort study of a new calprotectin-bas…
View article: O11 Outcomes of GP outreach programme offering colonoscopic surveillance for IBD patients managed in primary care
O11 Outcomes of GP outreach programme offering colonoscopic surveillance for IBD patients managed in primary care Open
Introduction Colonoscopic surveillance in IBD patients can reduce the development of colorectal cancer (CRC) and the rate of CRC-associated death. We recently reported that 27% of IBD patients living in East Devon are managed exclusively i…
View article: Root‐cause analyses of missed opportunities for the diagnosis of colorectal cancer in patients with inflammatory bowel disease
Root‐cause analyses of missed opportunities for the diagnosis of colorectal cancer in patients with inflammatory bowel disease Open
Summary Background Colonoscopic surveillance in patients with inflammatory bowel disease (IBD) leads to earlier detection of colorectal cancer (CRC) and reduces CRC‐associated mortality. However, it is limited by poor adherence in practice…
View article: Issue Information
Issue Information Open
No benefi t of continuing vs stopping 5-aminosalicylates in patients
View article: Incidence and prevalence of inflammatory bowel disease in Devon, UK
Incidence and prevalence of inflammatory bowel disease in Devon, UK Open
Background and aims We sought to define temporal changes in prevalence of inflammatory bowel disease (IBD) in East Devon, UK, in order to facilitate service planning over the next 5 years. Methods Multiple primary and secondary care databa…
View article: Clinical Features and Genetic Risk of Demyelination Following Anti-TNF Treatment
Clinical Features and Genetic Risk of Demyelination Following Anti-TNF Treatment Open
Background Anti-TNF exposure has been linked to demyelination events. We sought to describe the clinical features of demyelination events following anti-TNF treatment and to test whether affected patients were genetically predisposed to mu…
View article: Review article: prevention, diagnosis and management of COVID‐19 in the IBD patient
Review article: prevention, diagnosis and management of COVID‐19 in the IBD patient Open
Summary Background The current COVID‐19 pandemic, caused by SARS‐CoV‐2, has emerged as a public health emergency. All nations are seriously challenged as the virus spreads rapidly across the globe with no regard for borders. The primary ma…
View article: P250 Root cause analysis to identify missed opportunities for the diagnosis of colorectal cancer in inflammatory bowel disease
P250 Root cause analysis to identify missed opportunities for the diagnosis of colorectal cancer in inflammatory bowel disease Open
Background Colonoscopic surveillance in inflammatory bowel disease (IBD) patients leads to earlier detection of colorectal cancer (CRC) and reduces CRC-associated deaths. However, adherence to international surveillance guidelines in pract…
View article: N25 Outcomes of a GP outreach programme to offer colonoscopic surveillance for IBD patients being managed in primary care
N25 Outcomes of a GP outreach programme to offer colonoscopic surveillance for IBD patients being managed in primary care Open
Background Colonoscopic surveillance in IBD patients can reduce the development of colorectal cancer (CRC) and the rate of CRC-associated death. We recently reported that 27% of IBD patients living in East Devon are managed exclusively in …
View article: Factors associated with depression in people with inflammatory bowel disease: The relationship between active disease and biases in neurocognitive processing
Factors associated with depression in people with inflammatory bowel disease: The relationship between active disease and biases in neurocognitive processing Open
Background Depression is common among people with inflammatory bowel disease (IBD), though the causes remain unclear. We conducted a cross‐sectional study to investigate the role of emotional processing biases in contributing to depression…
View article: PTU-108 Prospective cohort to identify factors associated with diagnostic delay in patients with inflammatory bowel disease
PTU-108 Prospective cohort to identify factors associated with diagnostic delay in patients with inflammatory bowel disease Open
Background International cohort studies have previously identified Crohn's disease (CD), ileal disease, smoking, and age (Methods In total, 163 patients between the age of 18 and 46 years who first presented to their general practitioner (…
View article: Association of Genetic Variants in <i>NUDT15</i> With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease
Association of Genetic Variants in <i>NUDT15</i> With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease Open
Among patients of European ancestry with IBD, variants in NUDT15 were associated with increased risk of TIM. These findings suggest that NUDT15 genotyping may be considered prior to initiation of thiopurine therapy; however, further study …
View article: PTU-010 Prevalence and phenotype of IBD across primary and secondary care: implications for colorectal cancer surveillance
PTU-010 Prevalence and phenotype of IBD across primary and secondary care: implications for colorectal cancer surveillance Open
Introduction Patients diagnosed with colonic IBD have increased risk of colorectal cancer (CRC). Colonoscopic surveillance reduces the risk of CRC-associated death through early detection; national/international guidelines recommend chromo…
View article: Editorial: de novo inflammatory bowel disease following bariatric surgery—potential implications for research and clinical practice
Editorial: de novo inflammatory bowel disease following bariatric surgery—potential implications for research and clinical practice Open
Linked Content This article is linked to Ungaro et al and Ungaro and Colombel papers. To view these articles visit https://doi.org/10.1111/apt.14569 and https://doi.org/10.1111/apt.14667 .
View article: Faecal calprotectin effectively excludes inflammatory bowel disease in 789 symptomatic young adults with/without alarm symptoms: a prospective UK primary care cohort study
Faecal calprotectin effectively excludes inflammatory bowel disease in 789 symptomatic young adults with/without alarm symptoms: a prospective UK primary care cohort study Open
Summary Background Primary care faecal calprotectin testing distinguishes inflammatory bowel disease ( IBD ) from functional gut disorder in young patients presenting with abdominal symptoms; however, previous evaluations have excluded pat…
View article: OP035 NUDT15 variants contribute to thiopurine-induced myelosuppression in European populations
OP035 NUDT15 variants contribute to thiopurine-induced myelosuppression in European populations Open
The thiopurines (mercaptopurine [MP] and its prodrug azathioprine [AZA]) are the most commonly prescribed immunosuppressants used in the treatment of inflammatory bowel disease (IBD). However, their use is often curtailed by bone marrow su…
View article: P413 Exclusive enteral nutrition provides an effective bridge to safer interval elective surgery for Crohn's disease
P413 Exclusive enteral nutrition provides an effective bridge to safer interval elective surgery for Crohn's disease Open
Background: Despite data reporting that exclusive enteral nutrition (EEN) improves nutritional status and inflammation in patients with Crohn's disease, few studies have reported its systematic use in the perioperative setting. EEN involve…
View article: P550 Clinical features of demyelination following anti-TNFα therapy
P550 Clinical features of demyelination following anti-TNFα therapy Open
Background: Anti-TNFα therapy has been associated with demyelination since early trials in Multiple Sclerosis (MS) demonstrated disease exacerbation. Subsequent small case series have reported plausible clinical associations, although epid…
View article: Exclusive enteral nutrition provides an effective bridge to safer interval elective surgery for adults with Crohn's disease
Exclusive enteral nutrition provides an effective bridge to safer interval elective surgery for adults with Crohn's disease Open
Summary Background Few studies have reported the systematic use of exclusive enteral nutrition in the perioperative setting. Aim To test the hypothesis that exclusive enteral nutrition provides a safe and effective bridge to surgery and re…
View article: Prevalence of eosinophilic oesophagitis in adults presenting with oesophageal food bolus obstruction
Prevalence of eosinophilic oesophagitis in adults presenting with oesophageal food bolus obstruction Open
EO is present in approximately one third of patients who are admitted with FBO. Biopsies should be performed routinely at index endoscopy in order to pursue this treatable cause of long term morbidity.