Neel K. Prabhu
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View article: Clamshell thoracosternotomy for single-stage repair of select aortic arch pathologies
Clamshell thoracosternotomy for single-stage repair of select aortic arch pathologies Open
View article: Aberrant right subclavian artery intervention can provide relief of dysphagia
Aberrant right subclavian artery intervention can provide relief of dysphagia Open
Background: An aberrant right subclavian artery represents the most common aortic arch vascular anomaly. Conventional wisdom states that these anomalies do not result in dysphagia, but rather serve as “red herrings”. Clearly, in the vast m…
View article: Bioengineered Model of Human LGMD2B Skeletal Muscle Reveals Roles of Intracellular Calcium Overload in Contractile and Metabolic Dysfunction in Dysferlinopathy
Bioengineered Model of Human LGMD2B Skeletal Muscle Reveals Roles of Intracellular Calcium Overload in Contractile and Metabolic Dysfunction in Dysferlinopathy Open
Dysferlin is a multi‐functional protein that regulates membrane resealing, calcium homeostasis, and lipid metabolism in skeletal muscle. Genetic loss of dysferlin results in limb girdle muscular dystrophy 2B/2R (LGMD2B/2R) and other dysfer…
View article: Days alive and out of hospital for children born with single-ventricle heart disease
Days alive and out of hospital for children born with single-ventricle heart disease Open
Background: This study describes the illness burden in the first year of life for children with single-ventricle heart disease, using the metric of days alive and out of hospital to characterize morbidity and mortality. Methods: This is a …
View article: Cardiac Autonomic and Endothelial Function in Acute Lymphoblastic Leukaemia Patients Immediately After Chemotherapy and at the Three-Month Follow-up
Cardiac Autonomic and Endothelial Function in Acute Lymphoblastic Leukaemia Patients Immediately After Chemotherapy and at the Three-Month Follow-up Open
View article: Staged repair of borderline hypoplastic heart disease with early biventricular conversion
Staged repair of borderline hypoplastic heart disease with early biventricular conversion Open
View article: Textbook outcome for the Norwood operation—an informative quality metric in congenital heart surgery
Textbook outcome for the Norwood operation—an informative quality metric in congenital heart surgery Open
View article: Predictors of increased postoperative length of stay after complete atrioventricular canal repair
Predictors of increased postoperative length of stay after complete atrioventricular canal repair Open
Background: The optimal timing of surgical repair for infants with complete atrioventricular canal defect remains controversial, as there are risks to both early and late repair. We address this debate by investigating the association of v…
View article: Neonatal ventricular assist device implantation for high-risk hypoplastic left heart syndrome: How we do it
Neonatal ventricular assist device implantation for high-risk hypoplastic left heart syndrome: How we do it Open
View article: Staged left ventricular recruitment facilitated by Sano conduit upsizing
Staged left ventricular recruitment facilitated by Sano conduit upsizing Open
Sano conduit upsizing and fenestrated atrial septation is a simplified approach for staged left ventricular recruitment after the Norwood operation for select children with borderline left ventricles.
View article: Commentary: When short-circuiting is a good thing—miniaturized cardiopulmonary bypass decreases morbidity after heart surgery
Commentary: When short-circuiting is a good thing—miniaturized cardiopulmonary bypass decreases morbidity after heart surgery Open
Central MessageMiniaturized extracorporeal circulation may reduce adverse effects associated with traditional bypass. Should adoption of the strategy increase, it may be especially beneficial for pediatric patients.See Article page 418. Mi…
View article: Cardiovascular Autonomic Functions and Its Association with Oxidative Stress Marker in Heavy Smoking and Smokeless Tobacco Users of Low Socioeconomic Status
Cardiovascular Autonomic Functions and Its Association with Oxidative Stress Marker in Heavy Smoking and Smokeless Tobacco Users of Low Socioeconomic Status Open
Background: Tobacco usage is a major preventable cause for cardiovascular morbidity and mortality.Tobacco is used in both smoking and smokeless forms. Alteration in cardiac autonomic function is amajor predisposing factor for cardiovascula…
View article: Commentary: Don't leave patients to their own devices: Consider long-term complications after percutaneous atrial septal defect closure
Commentary: Don't leave patients to their own devices: Consider long-term complications after percutaneous atrial septal defect closure Open
Percutaneous device closure of atrial septal defects (ASDs) was introduced in the late 1990s as a feasible alternative to surgical repair.1 Since then, several studies have shown that short-term outcomes and complication rates after percut…
View article: Commentary: One size fits some—additional pulmonary blood flow at the Glenn operation and patient-specific factors
Commentary: One size fits some—additional pulmonary blood flow at the Glenn operation and patient-specific factors Open
View article: In Vitro Evaluation of Flow Distribution in All-Region Perfusion during the Norwood Operation
In Vitro Evaluation of Flow Distribution in All-Region Perfusion during the Norwood Operation Open
Continuous all-region perfusion has the potential to reduce total body ischemia during the Norwood procedure. This technique involves placing cannulas in the innominate artery, descending aorta, and native aortic root, thus providing conti…
View article: In Vitro Evaluation of Flow Distribution in All-Region Perfusion during the Norwood Operation.
In Vitro Evaluation of Flow Distribution in All-Region Perfusion during the Norwood Operation. Open
Continuous all-region perfusion has the potential to reduce total body ischemia during the Norwood procedure. This technique involves placing cannulas in the innominate artery, descending aorta, and native aortic root, thus providing conti…
View article: Sustained Total All-Region (STAR) Perfusion: An Optimized Perfusion Strategy for Norwood Reconstruction
Sustained Total All-Region (STAR) Perfusion: An Optimized Perfusion Strategy for Norwood Reconstruction Open
Early iterations of the Norwood procedure used aortic cross-clamping, myocardial arrest, and, sometimes, deep hypothermic circulatory arrest. The resulting hypothermia and prolonged ischemia caused frequent cardiac, neurologic, renal, and …
View article: Sustained Total All-Region (STAR) Perfusion: An Optimized Perfusion Strategy for Norwood Reconstruction.
Sustained Total All-Region (STAR) Perfusion: An Optimized Perfusion Strategy for Norwood Reconstruction. Open
Early iterations of the Norwood procedure used aortic cross-clamping, myocardial arrest, and, sometimes, deep hypothermic circulatory arrest. The resulting hypothermia and prolonged ischemia caused frequent cardiac, neurologic, renal, and …
View article: Identifying Key Genetic Regions for Cell Sheet Morphogenesis on Chromosome 2L Using a<i>Drosophila</i>Deficiency Screen in Dorsal Closure
Identifying Key Genetic Regions for Cell Sheet Morphogenesis on Chromosome 2L Using a<i>Drosophila</i>Deficiency Screen in Dorsal Closure Open
Cell sheet morphogenesis is essential for metazoan development and homeostasis of animal form – it contributes to developmental milestones including gastrulation, neural tube closure, heart and palate formation and to tissue maintenance du…
View article: Commentary: Ductal stenting for ductal-dependent pulmonary blood flow: Time for an exclusive club to expand its membership?
Commentary: Ductal stenting for ductal-dependent pulmonary blood flow: Time for an exclusive club to expand its membership? Open
View article: Tissue-Engineered Human Myobundle System as a Platform for Evaluation of Skeletal Muscle Injury Biomarkers
Tissue-Engineered Human Myobundle System as a Platform for Evaluation of Skeletal Muscle Injury Biomarkers Open
Traditional serum biomarkers used to assess skeletal muscle damage, such as activity of creatine kinase (CK), lack tissue specificity and sensitivity, hindering early detection of drug-induced myopathies. Recently, a novel four-factor skel…
View article: Reply: Taking surgical advancements in the developing world to heart—a case for trickle-up innovation?
Reply: Taking surgical advancements in the developing world to heart—a case for trickle-up innovation? Open
View article: Identifying Genetic Players in Cell Sheet Morphogenesis Using a<i>Drosophila</i>Deficiency Screen for Genes on Chromosome 2R Involved in Dorsal Closure
Identifying Genetic Players in Cell Sheet Morphogenesis Using a<i>Drosophila</i>Deficiency Screen for Genes on Chromosome 2R Involved in Dorsal Closure Open
Cell sheet morphogenesis characterizes key developmental transitions and homeostasis, in vertebrates and throughout phylogeny, including gastrulation, neural tube formation and wound healing. Dorsal closure, a process during Drosophila emb…
View article: Supplemental Material for Mortensen et al., 2018
Supplemental Material for Mortensen et al., 2018 Open
Two appendicies (Tables), 47 avi files that correspond to the images in Figures associated with the main text
View article: Early Cardiac Rehabilitation in a 14 year Old Male with Familial Hypercholesterolemia Post Coronary Artery Bypass Graft Surgery-a Case Report
Early Cardiac Rehabilitation in a 14 year Old Male with Familial Hypercholesterolemia Post Coronary Artery Bypass Graft Surgery-a Case Report Open
Familial Hypercholesterolemia is a genetic disorder caused by mutations in the genes encoding the low density lipoprotein (LDL) receptor consequently which results in elevated plasma levels of LDL. We report a case of a fourteen year old m…