Neel S. Bhatt
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View article: Oral Blarcamesine Phase IIb/III Trial Confirms Identified Precision Medicine Patient Population – Significant Broad Clinical and Quality of Life Improvements for Early Alzheimer’s Disease Patients
Oral Blarcamesine Phase IIb/III Trial Confirms Identified Precision Medicine Patient Population – Significant Broad Clinical and Quality of Life Improvements for Early Alzheimer’s Disease Patients Open
IMPORTANCE There are no approved oral disease-modifying treatments for Alzheimer’s disease (AD) with the ability to prolong time in a stable disease state and with clinically meaningful outcomes clear to patients and caregivers. DESIGN The…
View article: Work Status, Absenteeism, Presenteeism, and Quality of Life in Young Adult Cancer Survivors
Work Status, Absenteeism, Presenteeism, and Quality of Life in Young Adult Cancer Survivors Open
Importance Current literature lacks information on the association between the work status and performance of young adult cancer survivors and their quality of life (QOL). Objective To assess self-reported work status, missed time at work …
View article: Up-front alternative donor HCT in severe aplastic anemia: gaps and opportunities to translate evidence into practice
Up-front alternative donor HCT in severe aplastic anemia: gaps and opportunities to translate evidence into practice Open
Severe aplastic anemia (SAA) is a rare and life-threatening bone marrow failure disorder. Immunosuppressive therapy (IST) with antithymocyte globulin and cyclosporine has long been a frontline treatment option in SAA; however, its limited …
View article: Disease Burden at the Time of Transplantation Is a Primary Predictor of Outcomes in Pediatric MDS: A Single-Center Experience
Disease Burden at the Time of Transplantation Is a Primary Predictor of Outcomes in Pediatric MDS: A Single-Center Experience Open
Background: Hematopoietic cell transplantation (HCT) remains the only curative therapy for pediatric myelodysplastic syndrome (MDS) in all but rare cases. While HCT outcomes for pediatric MDS are similar across the largest registry and sin…
View article: Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: an observational cohort study
Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: an observational cohort study Open
View article: Transplant outcomes using older matched sibling donors compared with young alternative donors: a CIBMTR analysis
Transplant outcomes using older matched sibling donors compared with young alternative donors: a CIBMTR analysis Open
Whether older HLA-matched sibling donors (MSD) are preferred over younger alternative donors for allogeneic hematopoietic cell transplantation (allo-HCT) with posttransplant cyclophosphamide (PTCy)-based graft-versus-host disease (GVHD) pr…
View article: Derivation of a simple risk calculator for predicting clinical worsening in patients with pulmonary hypertension due to interstitial lung disease
Derivation of a simple risk calculator for predicting clinical worsening in patients with pulmonary hypertension due to interstitial lung disease Open
These two risk calculators provide a simple way to risk stratify ILD-PH patients with clinically useful discrimination. The calculators are easy to employ in clinical practice, since they utilize assessments commonly collected in the care …
View article: Blarcamesine for the treatment of Early Alzheimer's Disease: Results from the ANAVEX2-73-AD-004 Phase IIB/III trial
Blarcamesine for the treatment of Early Alzheimer's Disease: Results from the ANAVEX2-73-AD-004 Phase IIB/III trial Open
View article: Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities
Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities Open
There has been an increase in volume as well as an improvement in overall survival (OS) after hematopoietic cell transplantation (HCT) for hematologic disorders. It is unknown if these changes have affected racial/ethnic minorities equally…
View article: Decreasing chronic graft-versus-host disease rates in all populations
Decreasing chronic graft-versus-host disease rates in all populations Open
Since 2005, there has been a steady decline in chronic graft-versus-host disease (cGVHD) at the Fred Hutchinson Cancer Center. To better understand this phenomenon, we studied the risk of cGVHD requiring systemic immunosuppression (cGVHD-I…
View article: Chronic Health Conditions and Longitudinal Employment in Survivors of Childhood Cancer
Chronic Health Conditions and Longitudinal Employment in Survivors of Childhood Cancer Open
Importance Employment is an important factor in quality of life and provides social and economic support. Longitudinal data on employment and associations with chronic health conditions for adult survivors of childhood cancer are lacking. …
View article: Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities
Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities Open
There has been an increase in volume as well as an improvement in overall survival (OS) after hematopoietic cell transplantation (HCT) for hematologic disorders. It is unknown if these changes have affected racial/ethnic minorities equally…
View article: International recommendations for screening and preventative practices for long-term survivors of transplantation and cellular therapy: a 2023 update
International recommendations for screening and preventative practices for long-term survivors of transplantation and cellular therapy: a 2023 update Open
View article: International Recommendations for Screening and Preventative Practices for Long-Term Survivors of Transplantation and Cellular Therapy: A 2023 Update
International Recommendations for Screening and Preventative Practices for Long-Term Survivors of Transplantation and Cellular Therapy: A 2023 Update Open
As hematopoietic cell transplantation (HCT) and cellular therapy expand to new indications and international access improves, the number of HCTs performed annually continues to rise. Parallel improvements in HCT techniques and supportive c…
View article: Recommendations for surveillance of pulmonary dysfunction among childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group
Recommendations for surveillance of pulmonary dysfunction among childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group Open
View article: Return to school practices after hematopoietic cell transplantation: a survey of transplant centers in the United States
Return to school practices after hematopoietic cell transplantation: a survey of transplant centers in the United States Open
View article: Intensive care risk and long-term outcomes in pediatric allogeneic hematopoietic cell transplant recipients
Intensive care risk and long-term outcomes in pediatric allogeneic hematopoietic cell transplant recipients Open
Allogeneic hematopoietic cell transplantation (HCT) can be complicated by life-threatening organ toxicity and infection necessitating intensive care. Epidemiologic data have been limited by single-center studies, poor database granularity,…
View article: Return to School Practices After Hematopoietic Cell Transplantation: A Survey of Transplant Centers in the United States
Return to School Practices After Hematopoietic Cell Transplantation: A Survey of Transplant Centers in the United States Open
Current literature lacks transplant center recommendations on return-to-school timing and related support for hematopoietic cell transplant (HCT) survivors. We describe findings from a two-phase, cross-sectional, web-based survey: In Phase…
View article: Severity of Chronic Graft-versus-Host Disease and Late Effects Following Allogeneic Hematopoietic Cell Transplantation for Adults with Hematologic Malignancy
Severity of Chronic Graft-versus-Host Disease and Late Effects Following Allogeneic Hematopoietic Cell Transplantation for Adults with Hematologic Malignancy Open
View article: Unfavorable transcriptome profiles and social disadvantage in hematopoietic cell transplantation: a CIBMTR analysis
Unfavorable transcriptome profiles and social disadvantage in hematopoietic cell transplantation: a CIBMTR analysis Open
Patient-reported outcomes (PROs) capture subjective social determinants of health (SDOHs), which can affect health outcomes through the stress response pathway. The conserved transcriptional response to adversity (CTRA) is a stress-mediate…
View article: Incidence and Impact of Fungal Infections in Post-Transplantation Cyclophosphamide-Based Graft-versus-Host Disease Prophylaxis and Haploidentical Hematopoietic Cell Transplantation: A Center for International Blood and Marrow Transplant Research Analysis
Incidence and Impact of Fungal Infections in Post-Transplantation Cyclophosphamide-Based Graft-versus-Host Disease Prophylaxis and Haploidentical Hematopoietic Cell Transplantation: A Center for International Blood and Marrow Transplant Research Analysis Open
View article: No impact of CD34+ cell dose on outcome among children undergoing autologous hematopoietic stem cell transplant for high-risk neuroblastoma
No impact of CD34+ cell dose on outcome among children undergoing autologous hematopoietic stem cell transplant for high-risk neuroblastoma Open
View article: Recommendations for surveillance of pulmonary dysfunction among childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group
Recommendations for surveillance of pulmonary dysfunction among childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group Open
Childhood, adolescent, and young adult (CAYA) cancer survivors are at risk of pulmonary dysfunction. Current follow-up care guidelines are discordant. Therefore, the International Late Effects of Childhood Cancer Guideline Harmonization Gr…
View article: Critical Illness Risk and Long-Term Outcomes Following Intensive Care in Pediatric Hematopoietic Cell Transplant Recipients
Critical Illness Risk and Long-Term Outcomes Following Intensive Care in Pediatric Hematopoietic Cell Transplant Recipients Open
Background Allogeneic hematopoietic cell transplantation (HCT) can be complicated by the development of organ toxicity and infection necessitating intensive care. Risk factors for intensive care admission are unclear due to heterogeneity a…
View article: Financial Hardship in Childhood Cancer Survivors Treated with Hematopoietic Cell Transplantation: A Report from the Childhood Cancer Survivor Study
Financial Hardship in Childhood Cancer Survivors Treated with Hematopoietic Cell Transplantation: A Report from the Childhood Cancer Survivor Study Open
View article: Racial and Socioeconomic Disparities in Long-Term Outcomes in ≥1 Year Allogeneic Hematopoietic Cell Transplantation Survivors: A CIBMTR Analysis
Racial and Socioeconomic Disparities in Long-Term Outcomes in ≥1 Year Allogeneic Hematopoietic Cell Transplantation Survivors: A CIBMTR Analysis Open
Racial/ethnic minorities have demonstrated worse survival after allogeneic hematopoietic cell transplantation (HCT) compared to whites. Whether the racial disparity in HCT outcomes persists in long-term survivors and possibly may be even e…
View article: Disease burden at time of transplant is a primary predictor of outcomes in pediatric MDS: A single center experience
Disease burden at time of transplant is a primary predictor of outcomes in pediatric MDS: A single center experience Open
Hematopoietic cell transplantation (HCT) remains the only curative therapy for pediatric myelodysplastic syndrome (MDS) in all but rare cases . While HCT outcomes for pediatric MDS are similar across the largest registry and single center …
View article: Barriers and facilitators of the return‐to‐school process affecting adolescent recipients of allogeneic hematopoietic cell transplantation: A qualitative interview study of caregivers
Barriers and facilitators of the return‐to‐school process affecting adolescent recipients of allogeneic hematopoietic cell transplantation: A qualitative interview study of caregivers Open
Background Adolescent hematopoietic cell transplant (HCT) recipients remain out of school for a prolonged period of time; navigating their return to school after completion of therapy can be challenging for caregivers. Methods Between Augu…
View article: Evaluation of Children with Malignancies for Blood and Marrow Transplantation: A Report from the ASTCT Committee on Practice Guidelines
Evaluation of Children with Malignancies for Blood and Marrow Transplantation: A Report from the ASTCT Committee on Practice Guidelines Open
Evaluation of a candidate for hematopoietic cell transplantation (HCT) is a complex process with substantial intercenter variability. Although literature providing guidance for evaluating the eligibility of adults is well established, simi…
View article: Relationship between work performance and quality of life in long-term survivors of pediatric and adolescent hematopoietic cell transplant
Relationship between work performance and quality of life in long-term survivors of pediatric and adolescent hematopoietic cell transplant Open