Neelima Dhingra
YOU?
Author Swipe
View article: Three-dimensional Quantitative Structure–activity Relationship, Molecular Docking and Absorption, Distribution, Metabolism, and Excretion Studies of Lidocaine Analogs Pertaining to Voltage-gated Sodium Channel Nav1.7 Inhibition for the Management of Neuropathic Pain
Three-dimensional Quantitative Structure–activity Relationship, Molecular Docking and Absorption, Distribution, Metabolism, and Excretion Studies of Lidocaine Analogs Pertaining to Voltage-gated Sodium Channel Nav1.7 Inhibition for the Management of Neuropathic Pain Open
Aim: This study aims to design and develop novel lidocaine analogs specific for the Na v 1.7 channel using in silico approaches. Background: Neuropathic pain (NP) is defined as chronic pain originating from abnormalities found within the n…
View article: EXPLORING THE ACTIVITY OF SINIGRIN, A GLUCOSINOLATE AS AN ANTIMALARIAL
EXPLORING THE ACTIVITY OF SINIGRIN, A GLUCOSINOLATE AS AN ANTIMALARIAL Open
Background and Purpose: Plant derived antimalarials are indispensable for malaria treatment and a reliable source of new drugs. The present study first time explores antimalarial efficacy of sinigrin present in ethanolic whole plant extrac…
View article: 3D-QSAR, Molecular Docking and ADME Studies on Indole Analogues Reveal Antidepressant Activity Through Monoamine Oxidase-A Inhibition
3D-QSAR, Molecular Docking and ADME Studies on Indole Analogues Reveal Antidepressant Activity Through Monoamine Oxidase-A Inhibition Open
Monoamine oxidase (MAO) enzymes oversee the concentration of neurotransmitters and intracellular amines in the brain and peripheral tissues by catalysing their oxidative deamination and represents a crucial target in drug designing for the…
View article: Taurine as a potential therapeutic agent interacting with multiple signaling pathways implicated in autism spectrum disorder (ASD): An in-silico analysis
Taurine as a potential therapeutic agent interacting with multiple signaling pathways implicated in autism spectrum disorder (ASD): An in-silico analysis Open
Autism spectrum disorders (ASD) are a complex sequelae of neurodevelopmental disorders which manifest in the form of communication and social deficits. Currently, only two agents, namely risperidone and aripiprazole have been approved for …
View article: Structural and Biopharmaceutical Evaluation of Newly Synthesized Norfloxacin Co-Crystals Using Crystal Engineering Approach
Structural and Biopharmaceutical Evaluation of Newly Synthesized Norfloxacin Co-Crystals Using Crystal Engineering Approach Open
View article: Computer-Aided Drug Design and Development: An Integrated Approach
Computer-Aided Drug Design and Development: An Integrated Approach Open
Drug discovery and development is a very time- and resource-consuming process. Comprehensive knowledge of chemistry has been integrated with information technology to streamline drug discovery, design, development, and optimization. Comput…
View article: Design, Synthesis, and Quorum Quenching Potential of Novel Catechol–Zingerone Conjugate to Find an Elixir to Tackle Pseudomonas aeruginosa Through the Trojan Horse Strategy
Design, Synthesis, and Quorum Quenching Potential of Novel Catechol–Zingerone Conjugate to Find an Elixir to Tackle Pseudomonas aeruginosa Through the Trojan Horse Strategy Open
To address the issue of multidrug resistance in Pseudomonas aeruginosa , a novel catechol–zingerone conjugate ( 1 ) linked via a non-hydrolyzable 1,2,3-triazole linker was synthesized and subjected to biological evaluation based on the Tro…
View article: Target Specific Uptake of a Newly Synthesized Radiolabeled 5α-Reductase Inhibitor “Tc-99m-17-Oxo-17a-Aza-D-Homo-5-Androsten-3β-yl Phenoxyacetate (Tc-99m-17a-Aza Steroid)” in Rat Prostatic Neoplastic Lesions
Target Specific Uptake of a Newly Synthesized Radiolabeled 5α-Reductase Inhibitor “Tc-99m-17-Oxo-17a-Aza-D-Homo-5-Androsten-3β-yl Phenoxyacetate (Tc-99m-17a-Aza Steroid)” in Rat Prostatic Neoplastic Lesions Open
Objective: Considering the 5α-reductase (5AR) inhibitory activity of the oximes and the importance of the ester group in increasing the anti-androgenic property, we reasoned to synthesize a compound having a lactam group in ring D and an e…
View article: Antimalarial potential of ethanolic extract of winter bignonia rhizomes: In vitro and in vivo studies
Antimalarial potential of ethanolic extract of winter bignonia rhizomes: In vitro and in vivo studies Open
Background and Purpose: Day to day updates for increasing resistant cases even against artemisinin-based combination therapies has necessitated the need to develop new antiplasmodials. We evaluated the impact of crude ethanol extract of Be…
View article: Improved biopharmaceutical attributes of lumefantrine using choline mimicking drug delivery system: preclinical investigation on NK-65 <i>P.berghei</i> murine model
Improved biopharmaceutical attributes of lumefantrine using choline mimicking drug delivery system: preclinical investigation on NK-65 <i>P.berghei</i> murine model Open
Superior antimalarial efficacy and survival time with full recovery of infected mice revealed through histopathological studies.
View article: Lantadenes Targeting NF-ΚB in Cancer: Molecular Docking and ADMET Predictions
Lantadenes Targeting NF-ΚB in Cancer: Molecular Docking and ADMET Predictions Open
Natural products and their scaffolds encompasses an array of molecular entities as starting points for drug designing and discovery. In the past two decades, phytochemically driven Lantadenes and their modified analogues have attracted lot…
View article: 3-Thiocyanato- 1H- indoles as potential anticancer agents: Two dimensional quantitative structure activity relationship study
3-Thiocyanato- 1H- indoles as potential anticancer agents: Two dimensional quantitative structure activity relationship study Open
Introduction: In an attempt to find potent anti-cancer agents, we performed two-dimensional quantitative structure activity relationship (2D QSAR) studies, on a novel series of 3-thiocyanato-1H- indoles.
Method: 2D-QSAR was performed using…
View article: Steroidal 5α-Reductase: A Therapeutic Target for Prostate Disorders
Steroidal 5α-Reductase: A Therapeutic Target for Prostate Disorders Open
Steroidal 5α-reductase is a system of NADPH dependent enzyme that catalyzes the irreversible conversion of Δ4–3-ketosteroid precursor (testosterone) to its corresponding 5α-reduced metabolite (dihydrotestosterone). Initial role of DHT was …
View article: Genetic comparison among various coronavirus strains for the identification of potential vaccine targets of SARS-CoV2
Genetic comparison among various coronavirus strains for the identification of potential vaccine targets of SARS-CoV2 Open
View article: β-Carboline Derivatives Tackling Malaria: Biological Evaluation and Docking Analysis
β-Carboline Derivatives Tackling Malaria: Biological Evaluation and Docking Analysis Open
Increasing resistance to presently available antimalarial drugs urges the need to look for new promising compounds. The β-carboline moiety, present in several biologically active natural products and drugs, is an important scaffold for ant…
View article: An Overview of Novel Coronavirus Disease 2019: A Global Havoc
An Overview of Novel Coronavirus Disease 2019: A Global Havoc Open
: The world has been pushed to the edge of a precipice commonly been addressed to as Coronavirus S (SARS-CoV2), one of the world’s most widespread viral pandemic in recent times. Many studies are underway and investigating the new role of …
View article: Quinolinic acid, induces depression-like symptoms via Nrf2/ARE pathway in olfactory bulbectomized mice model of depression: In vivo and in silico studies
Quinolinic acid, induces depression-like symptoms via Nrf2/ARE pathway in olfactory bulbectomized mice model of depression: In vivo and in silico studies Open
View article: Design, Synthesis and Pharmacological Evaluation of Gastro- Protective Anti-inflammatory Analgesic Agents based on Dual Oxidative Stress / Cyclooxygenase Inhibition
Design, Synthesis and Pharmacological Evaluation of Gastro- Protective Anti-inflammatory Analgesic Agents based on Dual Oxidative Stress / Cyclooxygenase Inhibition Open
Background: Non-steroidal anti-inflammatory drugs (NSAIDs) derived local generation of reactive oxygen species (ROS) plays a crucial role in the formation of gastric ulceration. Objective: Therefore, anti-inflammatory analgesics with poten…
View article: DESIGN, SYNTHESIS, MOLECULAR DOCKING, AND EVALUATION OF CHROMONE BASED TETRAZOLE DERIVATIVES
DESIGN, SYNTHESIS, MOLECULAR DOCKING, AND EVALUATION OF CHROMONE BASED TETRAZOLE DERIVATIVES Open
Objectives: The objective of this research work was to design, synthesize, study the molecular docking, and evaluate the antimicrobial activity of some novel substituted 2-(Phenylamino)-3-(1H-tetrazol-5-yl)-4H-chromen-4-one derivatives (12…
View article: Finasteride in Prostate Cancer: A Hope or Hype
Finasteride in Prostate Cancer: A Hope or Hype Open
View article: Benzimidazole derivatives: search for GI-friendly anti-inflammatory analgesic agents
Benzimidazole derivatives: search for GI-friendly anti-inflammatory analgesic agents Open
Non-steroidal anti-inflammatory drugs (NSAIDs) have been successfully used for the alleviation of pain and inflammation in the past and continue to be used daily by millions of patients worldwide. However, gastrointestinal (GI) toxicity as…
View article: 17-Oxo-17a-Aza-D-Homo-5-Androsten-3β-Yl Esters: Cytotoxic To Liver and Neuroblastoma Cancer Cell Lines
17-Oxo-17a-Aza-D-Homo-5-Androsten-3β-Yl Esters: Cytotoxic To Liver and Neuroblastoma Cancer Cell Lines Open
Introduction and positioning of the heteroatom in the parental steroid skeleton has significant effect on the activity profile of these compounds. A substantial amount of biologically relevant azasteroids have been reported as antifungals,…