Norbert Frey
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View article: The European BestAgeing Study on microRNA candidates reveals distinct signatures with diagnostic and prognostic potential in cardiovascular disease
The European BestAgeing Study on microRNA candidates reveals distinct signatures with diagnostic and prognostic potential in cardiovascular disease Open
Background Circulating miRNAs have emerged as promising biomarker candidates due to their stability and their role in regulating key pathological pathways in cardiovascular disease (CVD). Yet, large-scale, multicentre studies examining the…
View article: Feasibility of computer-aided aortic occlusion catheter in non-traumatic cardiac arrest
Feasibility of computer-aided aortic occlusion catheter in non-traumatic cardiac arrest Open
A computer-aided automated aortic occlusion catheter can be safely implanted with a high success rate with regards to procedure time during ongoing cardiopulmonary resuscitation in patients suffering from cardiac arrest of non-traumatic or…
View article: Invasive Hemodynamics and Risk Stratification in T-TEER: Moving Beyond ESC Thresholds: EuroTR Registry Insights
Invasive Hemodynamics and Risk Stratification in T-TEER: Moving Beyond ESC Thresholds: EuroTR Registry Insights Open
BACKGROUND: Right heart catheterization plays a pivotal role in the preprocedural evaluation of patients considered for transcatheter tricuspid valve edge-to-edge repair. This study aimed to explore the potential impact of hemodynamic para…
View article: Deficiency for MicroRNA-582 does not impact dilated cardiomyopathy or heart failure induced by pressure overload in vivo
Deficiency for MicroRNA-582 does not impact dilated cardiomyopathy or heart failure induced by pressure overload in vivo Open
MicroRNAs (miRNAs) are critical post-transcriptional regulators of gene expression and have been extensively implicated in cardiovascular development, homeostasis, and disease. Among them, microRNA-582 (miR-582) has been associated with se…
View article: Profibrotic Biomarkers Correlate with Clinical Presentation and Outcome in Cardiac Transthyretin Amyloidosis
Profibrotic Biomarkers Correlate with Clinical Presentation and Outcome in Cardiac Transthyretin Amyloidosis Open
In transthyretin cardiac amyloidosis (ATTR-CA), misfolded transthyretin accumulates in the myocardium, leading to wall thickening and interstitial fibrosis. Recently published in vitro studies revealed direct effects of transthyretin on th…
View article: Fried's frailty phenotype predicts survival in pts with relapsed/refractory lymphoma or myeloma undergoing chimeric antigen receptor T-cell therapy – a prospective, observational Study
Fried's frailty phenotype predicts survival in pts with relapsed/refractory lymphoma or myeloma undergoing chimeric antigen receptor T-cell therapy – a prospective, observational Study Open
Chimeric antigen T-cell receptor (CART) therapy is highly effective for pts (pts) with relapsed/refractory (R/R) lymphoma/multiple myeloma (MM). However, due to concerns regarding tolerability, older pts are underrepresented in CART trials…
View article: Rheumatoid arthritis and cardiovascular disease associations in the UK Biobank
Rheumatoid arthritis and cardiovascular disease associations in the UK Biobank Open
Background This study evaluated observational and causal relationships between rheumatoid arthritis (RA) and cardiovascular disease and imaging phenotypes in the UK Biobank. Methods RA was defined using linked hospital records, self-report…
View article: Pre- or post-CAR-T allogeneic hematopoietic cell transplant provides relapse-free survival benefit for R/R Philadelphia negative B-cell acute lymphoblastic leukemia (B-ALL) successfully treated with brexucabtagene autoleucel in the real world
Pre- or post-CAR-T allogeneic hematopoietic cell transplant provides relapse-free survival benefit for R/R Philadelphia negative B-cell acute lymphoblastic leukemia (B-ALL) successfully treated with brexucabtagene autoleucel in the real world Open
Introduction: Brexucabtagene autoleucel (Brexu-cel) is a CD19-targeted chimeric antigen receptor (CAR-)T cell therapy approved for treatment of relapsed/refractory (r/r) B-ALL. Brexu-cel's approval was founded on data from the ZUMA-3 trial…
View article: Echocardiographic risk stratification in light chain and transthyretin amyloidosis: a meta-analysis
Echocardiographic risk stratification in light chain and transthyretin amyloidosis: a meta-analysis Open
Background Novel therapies decelerate the progression of cardiac amyloidosis, making precise prognostication essential for guiding therapeutic decision making. However, the role of echocardiography in risk stratification of light chain (AL…
View article: Mechanical Thrombectomy Reduces Increased High Sensitivity Troponin Levels in Intermediate-High Risk Pulmonary Embolism
Mechanical Thrombectomy Reduces Increased High Sensitivity Troponin Levels in Intermediate-High Risk Pulmonary Embolism Open
Mechanical thrombectomy in patients with pulmonary artery embolism at intermediate-high risk was associated with an immediate and significant decrease in both specific myocardial and systemic biomarkers, for which prognostic relevance has …
View article: A cross-study transcriptional patient map of heart failure defines conserved multicellular coordination in cardiac remodeling
A cross-study transcriptional patient map of heart failure defines conserved multicellular coordination in cardiac remodeling Open
View article: Direct Oral Anticoagulants or Warfarin for Left Ventricular Thrombus
Direct Oral Anticoagulants or Warfarin for Left Ventricular Thrombus Open
View article: Progression of QRS duration – a potential surrogate marker of survival in ATTRwt amyloidosis patients
Progression of QRS duration – a potential surrogate marker of survival in ATTRwt amyloidosis patients Open
View article: Cardiac Troponin I Antibodies Induce Cardiomyocyte Damage and Alter Cell Morphology
Cardiac Troponin I Antibodies Induce Cardiomyocyte Damage and Alter Cell Morphology Open
Circulating heart-reactive autoantibodies (aAbs) detected in a variety of heart diseases (e.g., myocarditis, dilated cardiomyopathy, and myocardial infarction) have been associated with the progression of heart failure and a poor prognosis…
View article: Clinical characteristics and etiology-specific outcome in pediatric hypertrophic cardiomyopathy
Clinical characteristics and etiology-specific outcome in pediatric hypertrophic cardiomyopathy Open
Introduction Childhood-onset cardiomyopathies are rare disease (incidence 1/100,000) presenting with diverse, potentially severe phenotypes. The etiologies range from idiopathic/sarcomeric forms to syndromic diseases, neuromuscular disorde…
View article: ZEB1 Is a Key Regulator of Cardiomyocyte Structure and Function
ZEB1 Is a Key Regulator of Cardiomyocyte Structure and Function Open
Background Our previous work identified the transcription factor “Zinc Finger E-Box Binding Homeobox 1” (ZEB1) as a downstream effector of Cytoplasmic Polyadenylation Element Binding Protein 4 (CPEB4), an RNA-binding protein responsive to …
View article: Deformable Image Registration for Self-supervised Cardiac Phase Detection in Multi-View Multi-Disease Cardiac Magnetic Resonance Images
Deformable Image Registration for Self-supervised Cardiac Phase Detection in Multi-View Multi-Disease Cardiac Magnetic Resonance Images Open
Cardiovascular magnetic resonance (CMR) is the gold standard for assessing cardiac function, but individual cardiac cycles complicate automatic temporal comparison or sub-phase analysis. Accurate cardiac keyframe detection can eliminate th…
View article: Spatial multiomics of acute myocardial infarction reveals immune cell infiltration through the endocardium
Spatial multiomics of acute myocardial infarction reveals immune cell infiltration through the endocardium Open
Myocardial infarction (MI) continues to be a leading cause of death worldwide. Even though it is well established that the complex interplay between different cell types determines the overall healing response after MI, the precise changes…
View article: Increased Pre-Transplant Carotid Intima-Media Thickness Is Associated with Early Post-Transplant Atrial Fibrillation, Stroke, and Reduced Survival After Heart Transplantation
Increased Pre-Transplant Carotid Intima-Media Thickness Is Associated with Early Post-Transplant Atrial Fibrillation, Stroke, and Reduced Survival After Heart Transplantation Open
Background: Carotid intima-media thickness (CIMT) is an established risk factor for adverse cardiovascular events in the general population, but its impact on patients after heart transplantation (HTX) remains unknown. We investigated the …
View article: Peak myocardial work index: a novel nonproprietary approach for the assessment of global constructive myocardial work by strain echocardiography
Peak myocardial work index: a novel nonproprietary approach for the assessment of global constructive myocardial work by strain echocardiography Open
Myocardial work indices (MW) have been validated with respect to their efficiency for predicting cardiac events in patients with heart failure. However, the measurement of MW requires specific vendor software that may not be ubiquitous acc…
View article: Impact of age on outcomes after transcatheter tricuspid valve edge-to-edge repair: insights from EuroTR
Impact of age on outcomes after transcatheter tricuspid valve edge-to-edge repair: insights from EuroTR Open
Objective Age stratified data regarding symptomatic and survival outcome of patients undergoing transcatheter tricuspid valve edge-to-edge repair (T-TEER) for severe tricuspid regurgitation (TR) are scarce. Aim of this study was to evaluat…
View article: Safety and prognostic value of left ventricular endomyocardial biopsy in dilated cardiomyopathy
Safety and prognostic value of left ventricular endomyocardial biopsy in dilated cardiomyopathy Open
Aims The need to perform endomyocardial biopsy (EMB) in patients with non‐ischaemic dilated cardiomyopathies (DCM) is debated. Here we sought to determine the extent of left ventricular collagen volume fraction (LV‐CVF) in DCM patients and…
View article: Longitudinal Effects of Lipid-Lowering Treatment on High-Risk Plaque Features and Pericoronary Adipose Tissue Attenuation Using Serial Coronary Computed Tomography
Longitudinal Effects of Lipid-Lowering Treatment on High-Risk Plaque Features and Pericoronary Adipose Tissue Attenuation Using Serial Coronary Computed Tomography Open
Aim: To evaluate the impact of different lipid-lowering treatment intensities on high-risk plaque features and pericoronary adipose tissue (PCAT) attenuation in patients undergoing serial coronary computed tomography angiography (CCTA). Me…
View article: Effects of mentoring on self-reflection and competence in Final year medical students’ internal medicine rotation
Effects of mentoring on self-reflection and competence in Final year medical students’ internal medicine rotation Open
Background Final year medical students (FYMS) in Germany transfer theoretical knowledge to clinical practice. However, there is a deficiency in structured guidance and feedback and self-reflective practices are often neglected. This study …
View article: Pre-Transplant Heavy Smoking Is Associated with Reduced Survival After Heart Transplantation Due to Infection and Malignancy
Pre-Transplant Heavy Smoking Is Associated with Reduced Survival After Heart Transplantation Due to Infection and Malignancy Open
Background: Tobacco smoking is a known risk factor for adverse cardiovascular events. Many patients after heart transplantation (HTX) have a history of smoking, but the prognostic role of pre-transplant smoking remains uncertain. We thus i…
View article: Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells
Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells Open
Chimeric antigen receptor (CAR) T cell therapy targeting CD19 elicits remarkable clinical efficacy in B cell malignancies, but many patients relapse owing to failed expansion and/or progressive loss of CAR-T cells. We recently reported a s…
View article: Heart failure therapy in patients with advanced cancer receiving specialized palliative care (EMPATICC trial)
Heart failure therapy in patients with advanced cancer receiving specialized palliative care (EMPATICC trial) Open
Background and Aims Advanced cancer may resemble a heart failure (HF)-like phenotype marked by cardiac wasting, dyspnoea, congestion, and/or physical dysfunction. The trial evaluated safety and efficacy of HF therapy among patients with ad…
View article: Elevated levels of Letm1 drives mitochondrial dysfunction and cardiomyocyte stress-mediated apoptosis in cultured cardiomyocytes
Elevated levels of Letm1 drives mitochondrial dysfunction and cardiomyocyte stress-mediated apoptosis in cultured cardiomyocytes Open
Background Cardiac ischemia, a predominant cause of heart failure, is marked by profound mitochondrial dysfunction, dysregulated ion homeostasis, and maladaptive cellular remodeling, all of which compromise cardiac performance. The mitocho…
View article: The impact of social determinants of health on outcomes of brexucabtagene autoleucel in adults with relapsed/refractory B-cell acute lymphoblastic leukemia
The impact of social determinants of health on outcomes of brexucabtagene autoleucel in adults with relapsed/refractory B-cell acute lymphoblastic leukemia Open
View article: Improvement in risk prediction for patients with atrial fibrillation and intermediate-risk CHA2DS2-VASc score utilizing highly sensitive cardiac troponin T
Improvement in risk prediction for patients with atrial fibrillation and intermediate-risk CHA2DS2-VASc score utilizing highly sensitive cardiac troponin T Open
Background Guidelines of the European Society of Cardiology recommend a clinical risk assessment for patients with atrial fibrillation (AF). However, scores such as the CHA 2 DS 2 -VASc score show only a modest performance for prediction o…