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View article: Risk factors associated with hepatitis B virus infection among patients attending gastroenterology outpatient department at public hospitals in Northeast Ethiopia: a hospital-based unmatched case-control study
Risk factors associated with hepatitis B virus infection among patients attending gastroenterology outpatient department at public hospitals in Northeast Ethiopia: a hospital-based unmatched case-control study Open
View article: Treatment of chronic hepatitis B in Ethiopia: 1-year results from a real-life, multicentre, prospective cohort study
Treatment of chronic hepatitis B in Ethiopia: 1-year results from a real-life, multicentre, prospective cohort study Open
The South-Eastern Norway Regional Health Authority and the John C Martin Foundation.
View article: Decentralization of hepatitis B care in sub-Saharan Africa: study protocol for a prospective cohort assessing three models of care in rural Ethiopia
Decentralization of hepatitis B care in sub-Saharan Africa: study protocol for a prospective cohort assessing three models of care in rural Ethiopia Open
View article: Correction: Antimicrobial resistance profile of Staphylococcus aureus isolated from patients, healthcare workers, and the environment in a tertiary hospital in Addis Ababa, Ethiopia
Correction: Antimicrobial resistance profile of Staphylococcus aureus isolated from patients, healthcare workers, and the environment in a tertiary hospital in Addis Ababa, Ethiopia Open
[This corrects the article DOI: 10.1371/journal.pone.0308615.].
View article: Performance of a Novel <i>P. falciparum</i> Rapid Diagnostic Test in Areas of Widespread <i>hrp2/3</i> Gene Deletion
Performance of a Novel <i>P. falciparum</i> Rapid Diagnostic Test in Areas of Widespread <i>hrp2/3</i> Gene Deletion Open
Background Rapid diagnostic tests (RDTs) have improved malaria diagnosis; however, the emergence of hrp2/3 gene deletions threatens the reliability of HRP2-based RDTs. This study evaluated the diagnostic performance of a novel RDT detectin…
View article: Schistosoma mansoni infection and hepatitis B surface antigen carriage rate among school children in Jille Timuga District, Amhara Region, Northeast Ethiopia
Schistosoma mansoni infection and hepatitis B surface antigen carriage rate among school children in Jille Timuga District, Amhara Region, Northeast Ethiopia Open
Background Hepatitis B virus (HBV) is highly prevalent and a major health problem in developing countries. Controversial findings are reported on the effect of schistosomiasis and HBV infection. This study aimed to describe the association…
View article: Prevalence and associated factors of tuberculosis among diabetic patients attending public health facilities in Ethiopia: a multicenter study
Prevalence and associated factors of tuberculosis among diabetic patients attending public health facilities in Ethiopia: a multicenter study Open
Diabetic patients attending public health facilities in Ethiopia had high TB prevalence. The prevalence of TB was higher among certain DM groups which implies the need for regular TB screening among those groups. The authors recommend the …
View article: Active tuberculosis among patients with presumptive tuberculosis with chronic kidney disease in a high tuberculosis burden country, Ethiopia: a multi-center study
Active tuberculosis among patients with presumptive tuberculosis with chronic kidney disease in a high tuberculosis burden country, Ethiopia: a multi-center study Open
TB is a substantial cause of morbidity among patients with CKD in Ethiopia, necessitating programmatic intervention. Thus, active TB screening and surveillance among patients with CKD in Ethiopia is important.
View article: Prevalence and intensity of Schistosoma mansoni infection, and contributing factors in Alamata district of Tigray Region, Northern Ethiopia
Prevalence and intensity of Schistosoma mansoni infection, and contributing factors in Alamata district of Tigray Region, Northern Ethiopia Open
Background Intestinal schistosomiasis caused by Schistosoma mansoni continues to be a significant public health problem in Ethiopia. This study investigated the prevalence and intensity of S . mansoni infection, and contributing factors in…
View article: Machine-learning methodologies to predict disease progression in chronic hepatitis B in Africa
Machine-learning methodologies to predict disease progression in chronic hepatitis B in Africa Open
Background: Little is known about the determinants of disease progression among African patients with chronic HBV infection. Methods: We used machine-learning models with longitudinal data to establish predictive algorithms in a well-chara…
View article: A prospective, multicenter study of hepatitis B birth-dose vaccine with or without hepatitis B immunoglobulin in preventing mother-to-child transmission of hepatitis B virus in Ethiopia
A prospective, multicenter study of hepatitis B birth-dose vaccine with or without hepatitis B immunoglobulin in preventing mother-to-child transmission of hepatitis B virus in Ethiopia Open
Birth-dose HBV vaccine with or without HBIg significantly reduced the risk of MTCT of HBV in Ethiopia. Improved coverage of birth-dose HBV vaccine should be an urgent priority.
View article: Antimicrobial resistance profile of Staphylococcus aureus isolated from patients, healthcare workers, and the environment in a tertiary hospital in Addis Ababa, Ethiopia
Antimicrobial resistance profile of Staphylococcus aureus isolated from patients, healthcare workers, and the environment in a tertiary hospital in Addis Ababa, Ethiopia Open
Staphylococcus aureus infection and colonization in patients may be transmitted to healthcare providers and the environment and subsequently cause healthcare-associated infections in other patients. Pathogenic S . aureus strains produce vi…
View article: Clinical trial: An open‐label, randomised trial of different re‐start strategies after treatment withdrawal in HBeAg negative chronic hepatitis B
Clinical trial: An open‐label, randomised trial of different re‐start strategies after treatment withdrawal in HBeAg negative chronic hepatitis B Open
Summary Background Stopping nucleos(t)ide analogue (NA) therapy in patients with chronic hepatitis B (CHB) may trigger a beneficial immune response leading to HBsAg loss, but clinical trials on re‐start strategies are lacking. Aim To asses…
View article: Medicinal Plants in Treating Hepatitis B Among Communities of Central Region of Ethiopia
Medicinal Plants in Treating Hepatitis B Among Communities of Central Region of Ethiopia Open
In this study, traditional healers used various plants to treat hepatitis. HBV-DNA suppressive activity was detected in three NAT-positive individuals who were treated by using a mixture of these frequently cited and highest preference-ran…
View article: Genotype characterization of Epstein–Barr virus among adults living with human immunodeficiency virus in Ethiopia
Genotype characterization of Epstein–Barr virus among adults living with human immunodeficiency virus in Ethiopia Open
Background Epstein–Barr virus (EBV) is a human lymphotropic herpesvirus with a causative agent in cancer. There are two genotypes of EBV (EBV genotype 1 and EBV genotype 2) that have been shown to infect humans. This study aimed to charact…
View article: Five-year results of a treatment program for chronic hepatitis B in Ethiopia
Five-year results of a treatment program for chronic hepatitis B in Ethiopia Open
View article: The Burden of Epstein–Barr Virus (EBV) and Its Determinants among Adult HIV-Positive Individuals in Ethiopia
The Burden of Epstein–Barr Virus (EBV) and Its Determinants among Adult HIV-Positive Individuals in Ethiopia Open
Epstein–Barr virus (EBV) is a well-known risk factor for the development of nasopharyngeal carcinoma, Hodgkin’s lymphoma (HL), and Non-Hodgkin’s lymphoma (NHL). People with HIV infection (PWH) are at increased risk for EBV-associated malig…
View article: Renal Safety of Long-term Tenofovir Disoproxil Fumarate Treatment in Patients With Chronic Hepatitis B
Renal Safety of Long-term Tenofovir Disoproxil Fumarate Treatment in Patients With Chronic Hepatitis B Open
Background Data on renal safety of tenofovir disoproxil fumarate (TDF) treatment among individuals with chronic hepatitis B (CHB) are inconsistent. The current study aimed to assess the effect of long-term TDF treatment on renal outcomes i…
View article: Antimicrobial Resistance and Virulence Gene Profile of Clinical Staphylococcus aureus: A Multi-Center Study from Ethiopia
Antimicrobial Resistance and Virulence Gene Profile of Clinical Staphylococcus aureus: A Multi-Center Study from Ethiopia Open
In this study, isolates were highly resistant to oral antibiotics and the pvl, seb, sea and TSST-1 genes were prevalent.
View article: RETRACTED: Climate Change and Emerging and Re-Emerging Tropical Infections
RETRACTED: Climate Change and Emerging and Re-Emerging Tropical Infections Open
Continual changes in climate have become a globally alarming phenomenon. Evidence showed that temperature is increasing from time to time globally, linked to the growing concentration of atmospheric energy-trapping gases, potentially creat…
View article: Cancer signs and risk factors awareness in Addis Ababa, Ethiopia: a population-based survey
Cancer signs and risk factors awareness in Addis Ababa, Ethiopia: a population-based survey Open
Background There is a paucity of data on public awareness of cancer in Ethiopia. This study assessed cancer signs, symptoms, and risk factors awareness among individuals aged 18 and older in Addis Ababa, Ethiopia. Method A population-based…
View article: Tuberculosis in individuals who recovered from COVID-19: A systematic review of case reports
Tuberculosis in individuals who recovered from COVID-19: A systematic review of case reports Open
Background The emergence of COVID-19 overwhelmed tuberculosis (TB) prevention and control, resulting in a decrease in TB detection rate and an increase in TB deaths. Furthermore, the temporary immunosuppressive effects, lung inflammation, …
View article: Occult Hepatitis B Virus Infection and Its Risks of Cryptic Transmission in Southern Ethiopia
Occult Hepatitis B Virus Infection and Its Risks of Cryptic Transmission in Southern Ethiopia Open
Gizachew Beykaso,1,2 Andargachew Mulu,3 Mirutse Giday,1 Nega Berhe,1 Markos Selamu,2 Dawit Hailu,3 Tilahun Teklehaymanot1 1Aklilu Lemma Institute of Pathobiology, Department of Molecular Biology and Immunology, Addis Ababa University, Addi…
View article: Co-infections and Comorbidities of Multiple Parasites and Hepatitis B Virus Infections in the Lowland Area of Western Ethiopia: Implications for Integrated Approaches
Co-infections and Comorbidities of Multiple Parasites and Hepatitis B Virus Infections in the Lowland Area of Western Ethiopia: Implications for Integrated Approaches Open
There was a high prevalence of infections in the study area. Morbidities such as undernutrition and anemia were still prominent public health problems. There was a significant association between infection status and undernutrition and ane…
View article: Burden and Transmission Risks of Viral Hepatitis in Southern Ethiopia: Evidence Needed for Prevention and Control Measures
Burden and Transmission Risks of Viral Hepatitis in Southern Ethiopia: Evidence Needed for Prevention and Control Measures Open
This study showed high prevalence of HBV infection, but low prevalence of HCV. This indicates that HBV is a major health problem in this community. Population-based surveillance, care, and treatment, as well as behavioral change and educat…
View article: Broad-Spectrum and Gram-Negative-Targeting Antibiotics Differentially Regulate Antibody Isotype Responses to Injected Vaccines
Broad-Spectrum and Gram-Negative-Targeting Antibiotics Differentially Regulate Antibody Isotype Responses to Injected Vaccines Open
Antibiotics are extensively used worldwide for the treatment of common infections by agents such as E. coli and Salmonella. They also represent the most common cause of alteration of the microbiota in people. We addressed whether broad-spe…
View article: Assessment of the COVID-19 related knowledge and its association with perceived worries of COVID-19 infection and severe illness among higher education students in 26 countries: A cross-sectional study
Assessment of the COVID-19 related knowledge and its association with perceived worries of COVID-19 infection and severe illness among higher education students in 26 countries: A cross-sectional study Open
Background During COVID-19, various public health measures such as physical distancing and distance learning are being implemented. As a consequence, higher education (HE) students face social as well as mental trauma at a crucial developm…
View article: CYTOKINE RESPONSE IN MONO AND MALARIA-S.MANSONI CO-INFECTED INDIVIDUALS IN FINCHA SUGAR ESTATE, WESTERN ETHIOPIA
CYTOKINE RESPONSE IN MONO AND MALARIA-S.MANSONI CO-INFECTED INDIVIDUALS IN FINCHA SUGAR ESTATE, WESTERN ETHIOPIA Open
Background: In Ethiopia, where malaria parasite and Schistosoma mansoni infections are coendemic, the general public is quite vulnerable to both malaria and S. mansoni infections singly and concomitantly. However, data about immunological …
View article: Estimating the Transmission Risks of Viral Hepatitis and HIV Among Blood Donors in Hossana, Southern Ethiopia
Estimating the Transmission Risks of Viral Hepatitis and HIV Among Blood Donors in Hossana, Southern Ethiopia Open
In this study, the magnitude of viral TTIs among blood donors is high. This indicates that there are high risks of transmission for these infectious pathogens. Therefore, effective stringent donor selection and screening protocols should b…
View article: Low awareness and common misconceptions about schistosomiasis in endemic lowland areas in Western Ethiopia: a mixed-methods study
Low awareness and common misconceptions about schistosomiasis in endemic lowland areas in Western Ethiopia: a mixed-methods study Open