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View article: Unveiling gas in the bowel wall: the role of point-of-care ultrasound in diagnosing pneumatosis intestinalis
Unveiling gas in the bowel wall: the role of point-of-care ultrasound in diagnosing pneumatosis intestinalis Open
View article: The Prognostic Implications of Change in LVEDP during TAVI
The Prognostic Implications of Change in LVEDP during TAVI Open
Background Elevated left ventricular end diastolic pressure (LVEDP) following transcatheter aortic valve implantation (TAVI) has been identified as a predictor of heart failure and mortality. Aims To determine whether change in LVEDP is a …
View article: Transcatheter aortic valve implantation complexity score
Transcatheter aortic valve implantation complexity score Open
Background Increasing demand for transcatheter aortic valve implantation (TAVI) places greater emphasis on the efficiency of pathways and services. A significant limitation to increasing TAVI capacity is the availability of cardiac cathete…
View article: A Review of Photoplethysmography-Based Blood Pressure Monitoring: From Cloud-Based Machine Learning to TinyML Edge Deployment
A Review of Photoplethysmography-Based Blood Pressure Monitoring: From Cloud-Based Machine Learning to TinyML Edge Deployment Open
View article: Geographical Inequality in Access to Aortic Valve Intervention in England: A Report from the UK Transcatheter Aortic Valve Implantation Registry and National Adult Cardiac Surgery Audit
Geographical Inequality in Access to Aortic Valve Intervention in England: A Report from the UK Transcatheter Aortic Valve Implantation Registry and National Adult Cardiac Surgery Audit Open
Background: For patients with severe aortic stenosis, transcatheter aortic valve implantation (TAVI) is a less invasive but equally effective treatment option compared with surgical aortic valve replacement (SAVR). In 2019, we reported low…
View article: Bicuspid valve CT registry of balloon‐expandable TAVR: BETTER TAVR registry
Bicuspid valve CT registry of balloon‐expandable TAVR: BETTER TAVR registry Open
Background The anatomic substrate of bicuspid valves may lead to suboptimal TAVR stent expansion and geometry. Aim We evaluated determinants of stent geometry in bicuspid valves treated with Sapien transcatheter aortic valve replacement (T…
View article: Percutaneous balloon mitral valvuloplasty with shockwave lithotripsy for the treatment of calcific mitral valve stenosis
Percutaneous balloon mitral valvuloplasty with shockwave lithotripsy for the treatment of calcific mitral valve stenosis Open
Background Calcific mitral stenosis (calcific MS) presents a challenge for surgical treatment and is a contraindication for most contemporary transcatheter mitral valve replacement devices (TMVR), rendering patients with very limited thera…
View article: European Society of Cardiology quality indicators for the care and outcomes of adults undergoing transcatheter aortic valve implantation
European Society of Cardiology quality indicators for the care and outcomes of adults undergoing transcatheter aortic valve implantation Open
Aims To develop a suite of quality indicators (QIs) for the evaluation of the care and outcomes for adults undergoing transcatheter aortic valve implantation (TAVI). Methods and results We followed the European Society of Cardiology (ESC) …
View article: Artificial intelligence in heart valve disease: diagnosis, innovation and treatment. A state-of-the-art review
Artificial intelligence in heart valve disease: diagnosis, innovation and treatment. A state-of-the-art review Open
In recent years, artificial intelligence (AI) has been used to improve the precision of valvular heart disease diagnosis and treatment. It has the ability to identify and risk stratify patients with valvular heart disease and holds promise…
View article: Cusp overlap method for self‐expanding transcatheter aortic valve replacement
Cusp overlap method for self‐expanding transcatheter aortic valve replacement Open
Background Conduction disturbances and the need for permanent pacemaker (PPM) implantation remains a common complication for transcatheter aortic valve replacement (TAVR), particularly when self‐expanding (SE) valves are used. Aims We comp…
View article: Utilization of Shock Team and Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) in the Management of Cardiogenic Shock in Northern Ontario
Utilization of Shock Team and Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) in the Management of Cardiogenic Shock in Northern Ontario Open
This analysis demonstrated the feasibility of implementing a shock team in remote Northern Ontario, enabling the use of VA-ECMO with success in a centre with a sizeable rural catchment area. This initiative helps address the gap in cardiac…
View article: Bicuspid valve CT Registry of balloon expandable TAVR: BETTER TAVR Registry
Bicuspid valve CT Registry of balloon expandable TAVR: BETTER TAVR Registry Open
Objectives We evaluated determinants of stent geometry in bicuspid valves treated with balloon expandable TAVR. Background The anatomic substrate of bicuspid valves may lead to suboptimal TAVR stent expansion and geometry. Methods A multic…
View article: The Safety of Early Discharge Following Transcatheter Aortic Valve Implantation Among Patients in Northern Ontario and Rural Areas Utilizing the Vancouver 3M TAVI Study Clinical Pathway
The Safety of Early Discharge Following Transcatheter Aortic Valve Implantation Among Patients in Northern Ontario and Rural Areas Utilizing the Vancouver 3M TAVI Study Clinical Pathway Open
View article: Double chimney stenting and triple kissing balloon inflation to prevent coronary obstruction during valve-in-valve TAVI with balloon valve fracture
Double chimney stenting and triple kissing balloon inflation to prevent coronary obstruction during valve-in-valve TAVI with balloon valve fracture Open
View article: A Comparison of Efficacy, Safety and Cost Between MANTATM and Proglide Vascular Closure Devices Following Transfemoral Transcatheter Aortic Valve Implantation
A Comparison of Efficacy, Safety and Cost Between MANTATM and Proglide Vascular Closure Devices Following Transfemoral Transcatheter Aortic Valve Implantation Open
Aims Access site vascular complications remain a recognised complication following transcatheter aortic valve implantation (TAVI). Suture-based vascular closure devices (VCDs) such as ProGlide® (Abbott Vascular Inc., Santa Clara, CA, USA) …
View article: ‘Valve for Life’: tackling the deficit in transcatheter treatment of heart valve disease in the UK
‘Valve for Life’: tackling the deficit in transcatheter treatment of heart valve disease in the UK Open
Transcatheter aortic valve implantation (TAVI) is a proven treatment for life-threatening aortic valve disease, predominantly severe aortic stenosis. However, even among developed nations, access to TAVI is not uniform. The Valve for Life …
View article: Transcatheter Aortic Valve Replacement With the LOTUS Edge System
Transcatheter Aortic Valve Replacement With the LOTUS Edge System Open
View article: Untreatable Severe Structural Degeneration of a Transcatheter Aortic Heart Valve
Untreatable Severe Structural Degeneration of a Transcatheter Aortic Heart Valve Open
View article: Leadless pacemakers – The path to safer pacing?
Leadless pacemakers – The path to safer pacing? Open
Endocardial transvenous permanent pacemakers (TVPs) are a mainstay within cardiology and used to treat a range of bradyarrhythmias. However, their use is associated with potential complications both at the time of implantation and longer t…
View article: BS36 Reduced insulin-like growth factor-1 receptor expression enhances vascular repair and regeneration in whole body insulin resistance
BS36 Reduced insulin-like growth factor-1 receptor expression enhances vascular repair and regeneration in whole body insulin resistance Open
Introduction Insulin resistance is an independent risk factor for cardiovascular disease. We have previously shown that the insulin-like growth factor-1 receptor (IGF-1R) is a negative regulator of insulin receptor (IR) signalling, by sequ…
View article: 129 Prosthetic valve endocarditis following transcatheter aortic valve implantation – experience from a UK centre
129 Prosthetic valve endocarditis following transcatheter aortic valve implantation – experience from a UK centre Open
Introduction Prosthetic valve endocarditis (PVE) is a recognised and serious complication following surgical aortic valve replacement, with an incidence of 0.3–1.2% per year and an in-hospital mortality of >20%. The incidence and outcomes …
View article: Non-Pharmacological Interventions in Refractory Angina
Non-Pharmacological Interventions in Refractory Angina Open
Refractory angina (RA) is defined by intractable cardiac chest pain despite standard medical therapy and revascularisation.Symptoms are associated with significant morbidity and compromised quality of life (QoL).Various methods of interven…
View article: Use of the MANTA device to rescue failed pre-closure following transfemoral transcatheter aortic valve implantation
Use of the MANTA device to rescue failed pre-closure following transfemoral transcatheter aortic valve implantation Open
View article: Effects of Ivabradine on Hemodynamic and Functional Parameters in Left Ventricular Systolic Dysfunction: a Systematic Review and Meta-analysis
Effects of Ivabradine on Hemodynamic and Functional Parameters in Left Ventricular Systolic Dysfunction: a Systematic Review and Meta-analysis Open
View article: Trans-catheter aortic valve implantation without contrast using the Lotus mechanically-expanded heart valve
Trans-catheter aortic valve implantation without contrast using the Lotus mechanically-expanded heart valve Open
View article: Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice
Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice Open
Reduced systemic insulin signaling promotes endothelial dysfunction and diminished endogenous vascular repair. We investigated whether restoration of endothelial insulin receptor expression could rescue this phenotype. Insulin receptor kno…
View article: Heart failure with preserved ejection fraction (HF-PEF): A mini-review
Heart failure with preserved ejection fraction (HF-PEF): A mini-review Open
Heart Failure with Preserved Ejection Fraction (HF-PEF) describes patients with classic symptoms but without left ventricular systolic impairment (ejection fraction ≥ 50%).These cohorts have features of diastolic dysfunction which is consi…
View article: Recent developments and controversies in transcatheter aortic valve implantation
Recent developments and controversies in transcatheter aortic valve implantation Open
Interventional cardiology has been revolutionised by transcatheter aortic valve implantation (TAVI), which has become established as the benchmark treatment for severe aortic stenosis in patients at high risk for surgical aortic valve repl…
View article: Mechanisms involved in regulation of Systemic Blood Pressure
Mechanisms involved in regulation of Systemic Blood Pressure Open
Regulation of the circulatory system to maintain a constant arterial pressure is critical in ensuring adequate perfusion to meet metabolic requirements of tissues. Blood pressure (BP) can be considered in the context of Ohm’s law, whereby …
View article: 232 Endothelial ship2 knockout causes nox2 nadph oxidase-dependent oxidative stress and endothelial dysfunction
232 Endothelial ship2 knockout causes nox2 nadph oxidase-dependent oxidative stress and endothelial dysfunction Open
Introduction Insulin-resistant type 2 diabetes mellitus (DM) leads to premature death and disability, primarily as a consequence of accelerated vascular disease. Shc homology 2-containing inositol 5 phosphatase-2 (SHIP2) is a lipid phospha…