Nehemiah T. Zewde
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View article: Systems Biology Modeling of the Complement System Under Immune Susceptible Pathogens
Systems Biology Modeling of the Complement System Under Immune Susceptible Pathogens Open
The complement system is assembled from a network of proteins that function to bring about the first line of defense of the body against invading pathogens. However, complement deficiencies or invasive pathogens can hijack complement to su…
View article: Role of Electrostatic Hotspots in the Selectivity of Complement Control Proteins Toward Human and Bovine Complement Inhibition
Role of Electrostatic Hotspots in the Selectivity of Complement Control Proteins Toward Human and Bovine Complement Inhibition Open
Poxviruses are dangerous pathogens, which can cause fatal infection in unvaccinated individuals. The causative agent of smallpox in humans, variola virus , is closely related to the bovine vaccinia virus , yet the molecular basis of their …
View article: Spontaneous Embedding of DNA Mismatches Within the RNA:DNA Hybrid of CRISPR-Cas9
Spontaneous Embedding of DNA Mismatches Within the RNA:DNA Hybrid of CRISPR-Cas9 Open
CRISPR-Cas9 is the forefront technology for editing the genome. In this system, the Cas9 protein is programmed with guide RNAs to process DNA sequences that match the guide RNA forming an RNA:DNA hybrid structure. However, the binding of D…
View article: Factor H-Inspired Design of Peptide Biomarkers of the Complement C3d Protein
Factor H-Inspired Design of Peptide Biomarkers of the Complement C3d Protein Open
C3d is a hallmark protein of the complement system, whose presence is critical to measure the progression of several immune diseases. Here, we propose to directly target C3d through small peptides mimicking the binding of its natural ligan…
View article: Multiscale Solutions to Quantitative Systems Biology Models
Multiscale Solutions to Quantitative Systems Biology Models Open
OPINION article Front. Mol. Biosci., 30 October 2019 | https://doi.org/10.3389/fmolb.2019.00119
View article: Computational Modeling and Mechanistic Elucidation of the Complement System Under Homeostasis, Disease, and Therapeutic Interventions
Computational Modeling and Mechanistic Elucidation of the Complement System Under Homeostasis, Disease, and Therapeutic Interventions Open
The complement system is a major part of the innate immune system that targets invading pathogens and assists in maintaining host homeostasis. Complement is composed of three pathways known as alternative (AP), classical (CP), and lectin (…
View article: Immunophysical Evaluation of the Initiating Step in the Formation of the Membrane Attack Complex
Immunophysical Evaluation of the Initiating Step in the Formation of the Membrane Attack Complex Open
The complex between complement system proteins C5b and C6 is the cornerstone for the assembly of the membrane attack complex (MAC, also known as C5b6789n). MAC is the terminal product of three converging pathways of the complement system a…
View article: A computational model for the evaluation of complement system regulation under homeostasis, disease, and drug intervention
A computational model for the evaluation of complement system regulation under homeostasis, disease, and drug intervention Open
The complement system is an intricate defense network that rapidly removes invading pathogens. Although many complement regulators are present to protect host cells under homeostasis, the impairment of Factor H (FH) regulatory mechanism ha…
View article: A Computational Model for the Evaluation of Complement System Regulation under Homeostasis, Disease, and Drug Intervention
A Computational Model for the Evaluation of Complement System Regulation under Homeostasis, Disease, and Drug Intervention Open
Highlights Computational model describing dynamics of complement system activation pathways Complement dysregulation leads to deviation from homeostasis and to inflammatory diseases Model identifies biomarkers to quantify the effects of co…
View article: Quantitative Modeling of the Alternative Pathway of the Complement System
Quantitative Modeling of the Alternative Pathway of the Complement System Open
The complement system is an integral part of innate immunity that detects and eliminates invading pathogens through a cascade of reactions. The destructive effects of the complement activation on host cells are inhibited through versatile …