Neil Bahroos
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View article: 27 Automated IRB compliance and secure data delivery in i2b2
27 Automated IRB compliance and secure data delivery in i2b2 Open
Objectives/Goals: To address the manual, time-consuming processes of validating IRB compliance and ensuring the secure delivery of i2b2 data, this project automates compliance checks, streamlines Protected Health Information (PHI) access, …
View article: 567 Optimizing clinical trial recruitment: A dashboard for accrual and oversight
567 Optimizing clinical trial recruitment: A dashboard for accrual and oversight Open
Objectives/Goals: To identify clinical trial teams that are at risk of not meeting their recruitment goals as early in the recruitment period as possible, this project aims to provide timely accrual information and projected forecasts for …
View article: Environment scan of generative AI infrastructure for clinical and translational science
Environment scan of generative AI infrastructure for clinical and translational science Open
View article: Estimation of prevalence of autoimmune diseases in the United States using electronic health record data
Estimation of prevalence of autoimmune diseases in the United States using electronic health record data Open
BACKGROUNDPrevious epidemiologic studies of autoimmune diseases in the US have included a limited number of diseases or used metaanalyses that rely on different data collection methods and analyses for each disease.METHODSTo estimate the p…
View article: Implementing a Common Data Model in Ophthalmology: Mapping Structured Electronic Health Record Ophthalmic Examination Data to Standard Vocabularies
Implementing a Common Data Model in Ophthalmology: Mapping Structured Electronic Health Record Ophthalmic Examination Data to Standard Vocabularies Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Environment Scan of Generative AI Infrastructure for Clinical and Translational Science
Environment Scan of Generative AI Infrastructure for Clinical and Translational Science Open
This study reports a comprehensive environmental scan of the generative AI (GenAI) infrastructure in the national network for clinical and translational science across 36 institutions supported by the Clinical and Translational Science Awa…
View article: Feasibility of Privacy-Preserving Entity Resolution on Confidential Healthcare Datasets Using Homomorphic Encryption
Feasibility of Privacy-Preserving Entity Resolution on Confidential Healthcare Datasets Using Homomorphic Encryption Open
Patient datasets contain confidential information which is protected by laws and regulations such as HIPAA and GDPR. Ensuring comprehensive patient information necessitates privacy-preserving entity resolution (PPER), which identifies iden…
View article: 324 An umbrella protocol that establishes an enterprise-wide framework for the operation of a Clinical Data Warehouse
324 An umbrella protocol that establishes an enterprise-wide framework for the operation of a Clinical Data Warehouse Open
OBJECTIVES/GOALS: To streamline the standards and procedures for operating a research-specific, clinical data warehouse, acheived by defining roles, introducing a common language, and categorizing dataset types to provide transparency rega…
View article: Compliance considerations in the geo-enrichment of an EHR data warehouse with social and environmental determinants of health
Compliance considerations in the geo-enrichment of an EHR data warehouse with social and environmental determinants of health Open
Social and environmental determinants of health (SEDoH) are crucial for achieving a holistic understanding of patient health. In fact, geographic factors may have more influence on health outcomes than patients’ genetics. Integrating SEDoH…
View article: Integrating REDCap patient-reported outcomes with the HealtheIntent population health platform: proof of concept
Integrating REDCap patient-reported outcomes with the HealtheIntent population health platform: proof of concept Open
Objective Patient-reported outcome measures (PROMs) are critical to drive patient-centered care and to understanding patients’ perspectives on their health status, quality of life, and the overall effectiveness of the care they receive. PR…
View article: Dataset S2 from Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications
Dataset S2 from Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications Open
GO terms associated with upregulated genes bearing new ∙NO-induced H3K9ac peaks around promoter regions
View article: Dataset S1 from Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications
Dataset S1 from Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications Open
GO terms associated with ∙NO-regulated genes
View article: Supplementary Materials and Methods, Supplementary Figures 1 through 4 and Supplementary Tables 1 through 4 from Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications
Supplementary Materials and Methods, Supplementary Figures 1 through 4 and Supplementary Tables 1 through 4 from Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications Open
Supplementary Materials and Methods. Figure S1. Nitric oxide induces significant changes in histone posttranslational modifications. Figure S2. NO-mediated gene expression changes are consistent with the induction of an oncogenic phenotype…
View article: Data from Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications
Data from Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications Open
Altered nitric oxide (•NO) metabolism underlies cancer pathology, but mechanisms explaining many •NO-associated phenotypes remain unclear. We have found that cellular exposure to •NO changes histone posttranslational modifications (PTM) by…
View article: Supplementary Materials and Methods, Supplementary Figures 1 through 4 and Supplementary Tables 1 through 4 from Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications
Supplementary Materials and Methods, Supplementary Figures 1 through 4 and Supplementary Tables 1 through 4 from Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications Open
Supplementary Materials and Methods. Figure S1. Nitric oxide induces significant changes in histone posttranslational modifications. Figure S2. NO-mediated gene expression changes are consistent with the induction of an oncogenic phenotype…
View article: Dataset S2 from Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications
Dataset S2 from Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications Open
GO terms associated with upregulated genes bearing new ∙NO-induced H3K9ac peaks around promoter regions
View article: Data from Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications
Data from Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications Open
Altered nitric oxide (•NO) metabolism underlies cancer pathology, but mechanisms explaining many •NO-associated phenotypes remain unclear. We have found that cellular exposure to •NO changes histone posttranslational modifications (PTM) by…
View article: Dataset S1 from Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications
Dataset S1 from Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications Open
GO terms associated with ∙NO-regulated genes
View article: Development of a social and environmental determinants of health informatics maturity model
Development of a social and environmental determinants of health informatics maturity model Open
Introduction: Integrating social and environmental determinants of health (SEDoH) into enterprise-wide clinical workflows and decision-making is one of the most important and challenging aspects of improving health equity. We engaged domai…
View article: Sendae: A Resource for Expanding Research into Social and Environmental Determinants of Health
Sendae: A Resource for Expanding Research into Social and Environmental Determinants of Health Open
View article: Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative
Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative Open
This cohort study found that COVID-19 mortality decreased over time during 2020 and that patient demographic characteristics and comorbidities were associated with higher clinical severity. The machine learning models accurately predicted …
View article: Development of a Coronavirus Disease 2019 (COVID-19) Application Ontology for the Accrual to Clinical Trials (ACT) network
Development of a Coronavirus Disease 2019 (COVID-19) Application Ontology for the Accrual to Clinical Trials (ACT) network Open
Clinical data networks that leverage large volumes of data in electronic health records (EHRs) are significant resources for research on coronavirus disease 2019 (COVID-19). Data harmonization is a key challenge in seamless use of multisit…
View article: Development of a COVID-19 Application Ontology for the ACT Network
Development of a COVID-19 Application Ontology for the ACT Network Open
Clinical data networks that leverage large volumes of data in electronic health records (EHRs) are significant resources for research on coronavirus disease 2019 (COVID-19). Data harmonization is a key challenge in seamless use of multisit…
View article: 2545
2545 Open
OBJECTIVES/SPECIFIC AIMS: This research project envisions the integration of Homeless Management Information System (HMIS) and UI Health Cerner electronic medical record (EMR) system with the following goals: (1) enable sharing of data abo…
View article: The IRF4 Gene Regulatory Module Functions as a Read-Write Integrator to Dynamically Coordinate T Helper Cell Fate
The IRF4 Gene Regulatory Module Functions as a Read-Write Integrator to Dynamically Coordinate T Helper Cell Fate Open
View article: Association of circulating transcriptomic profiles with mortality in sickle cell disease
Association of circulating transcriptomic profiles with mortality in sickle cell disease Open
Key Points We validated the association of a circulating genome-wide gene expression profile with poor outcomes in 3 cohorts of SCD. A composite risk score using this genomic biomarker with clinical risk factors exhibited improved predicti…
View article: Human Lacrimal Gland Gene Expression
Human Lacrimal Gland Gene Expression Open
Differential gene expression in human lacrimal gland compared with other ectodermal tissue types revealed interesting patterns which may serve as the basis for future studies in directed differentiation among other areas.
View article: Comparison of metagenomics taxonomy assignment methods: popular softwares and NCBI mega-blast
Comparison of metagenomics taxonomy assignment methods: popular softwares and NCBI mega-blast Open
View article: Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications
Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications Open
Altered nitric oxide (•NO) metabolism underlies cancer pathology, but mechanisms explaining many •NO-associated phenotypes remain unclear. We have found that cellular exposure to •NO changes histone posttranslational modifications (PTM) by…
View article: Histone reader BRWD1 targets and restricts recombination to the Igk locus
Histone reader BRWD1 targets and restricts recombination to the Igk locus Open