Neil D. Woodward
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View article: Nonlinear associations between reported childhood trauma and cognitive impairment in schizophrenia spectrum disorders
Nonlinear associations between reported childhood trauma and cognitive impairment in schizophrenia spectrum disorders Open
We provide novel evidence for nonlinear associations between trauma and cognition, which may account for discrepancy among existing studies and suggest sensitivity of neural substrates of memory to particular levels of trauma. Our results …
View article: Subtyping psychotic disorders using a data-driven approach reveals divergent cortical and cellular signatures
Subtyping psychotic disorders using a data-driven approach reveals divergent cortical and cellular signatures Open
Structural brain abnormalities in psychosis are well-replicated but heterogenous posing a barrier to uncovering the pathophysiology, etiology, and treatment of psychosis. To parse neurostructural heterogeneity and assess for the presence o…
View article: A two-year longitudinal investigation of insula subregional cortical thickness and surface area in early psychosis
A two-year longitudinal investigation of insula subregional cortical thickness and surface area in early psychosis Open
In early psychosis, insula cortical thickness, but not surface area, is disrupted, and demonstrates normative changes over two years. This pattern is observed for all insula subregions. These data suggest that cortical thickness of the ins…
View article: Cerebellar-Prefrontal Connectivity Predicts Negative Symptom Severity Across the Psychosis Spectrum
Cerebellar-Prefrontal Connectivity Predicts Negative Symptom Severity Across the Psychosis Spectrum Open
Our results extend relationships between cerebellar-DLPFC connectivity, negative symptom severity, and cognitive performance across the psychosis spectrum. Larger neuromodulation studies should test whether increasing cerebellar-DLPFC conn…
View article: Hippocampal volume in affective and non-affective psychosis
Hippocampal volume in affective and non-affective psychosis Open
Hippocampal volume change in non-affective psychotic disorders begins in the anterior region and spreads to the posterior region as the illness progresses. It is unclear whether similar hippocampal volume changes are present in affective p…
View article: Prior Expectations of Volatility Following Psychotherapy for Delusions
Prior Expectations of Volatility Following Psychotherapy for Delusions Open
Importance Persecutory delusions are common, distressing, and difficult to treat. Testing computational neuroscience models of delusions can identify new therapeutic targets. Objective To determine whether change in delusion severity is as…
View article: Insular functional connectivity in autistic and non-autistic development
Insular functional connectivity in autistic and non-autistic development Open
These findings shed light on potential developmental shifts in how interoceptive processing is balanced between lower-order and higher-order areas. Further, they provide background for how autistic patterns of interoceptive processing may …
View article: Characterizing massa intermedia morphology in schizophrenia: associations with aging, neuropsychological functioning, and atypical hippocampal development
Characterizing massa intermedia morphology in schizophrenia: associations with aging, neuropsychological functioning, and atypical hippocampal development Open
The massa intermedia (MI) is a midline structure connecting the left and right thalamus that typically develops during the 2 nd trimester of pregnancy. Missing and smaller MI has been linked to neurodevelopmental disorders, including schiz…
View article: Semiparametric Confidence Sets for Arbitrary Effect Sizes in Longitudinal Neuroimaging
Semiparametric Confidence Sets for Arbitrary Effect Sizes in Longitudinal Neuroimaging Open
The majority of neuroimaging inference focuses on hypothesis testing rather than effect estimation. With concerns about replicability, there is growing interest in reporting standardized effect sizes from neuroimaging group-level analyses.…
View article: Semiparametric confidence sets for cross-sectional and longitudinal neuroimaging
Semiparametric confidence sets for cross-sectional and longitudinal neuroimaging Open
The majority of neuroimaging inference focuses on hypothesis testing rather than effect estimation. With concerns about replicability, there is growing interest in reporting standardized effect sizes from neuroimaging group-level analyses.…
View article: Distress and Negative Subtypes of Schizophrenia: Identification, Characterization, and Neurostructural Profiles
Distress and Negative Subtypes of Schizophrenia: Identification, Characterization, and Neurostructural Profiles Open
Background Heterogeneity in schizophrenia spectrum disorders is a major challenge to implementing personalized medicine and uncovering etiological pathways. Recent work identified subtypes of schizophrenia that exhibit unique patterns of c…
View article: Nonlinear Associations between Reported Childhood Trauma and Cognitive Impairment in Schizophrenia Spectrum Disorders
Nonlinear Associations between Reported Childhood Trauma and Cognitive Impairment in Schizophrenia Spectrum Disorders Open
View article: A 2-year longitudinal investigation of insula subregional volumes in early psychosis
A 2-year longitudinal investigation of insula subregional volumes in early psychosis Open
Background The insula is a heterogeneous cortical region with three cytoarchitectural subregions— agranular, dysgranular, and granular—that have distinct functional roles. Previous cross- sectional studies have shown smaller volume of all …
View article: Cerebellar-Prefrontal Connectivity Predicts Negative Symptom Severity Across the Psychosis Spectrum
Cerebellar-Prefrontal Connectivity Predicts Negative Symptom Severity Across the Psychosis Spectrum Open
Background Negative symptom severity predicts functional outcome and quality life in people with psychosis. However, negative symptoms are poorly responsive to antipsychotic medication and existing literature has not converged on their neu…
View article: A prefrontal thalamocortical readout for conflict-related executive dysfunction in schizophrenia
A prefrontal thalamocortical readout for conflict-related executive dysfunction in schizophrenia Open
View article: The insula: Leveraging cellular and systems-level research to better understand its roles in health and schizophrenia
The insula: Leveraging cellular and systems-level research to better understand its roles in health and schizophrenia Open
Schizophrenia is a highly heterogeneous disorder characterized by a multitude of complex and seemingly non-overlapping symptoms. The insular cortex has gained increasing attention in neuroscience and psychiatry due to its involvement in a …
View article: Threat Responses in Schizophrenia: A Negative Valence Systems Framework
Threat Responses in Schizophrenia: A Negative Valence Systems Framework Open
View article: Evaluation of resampling-based inference for topological features of neuroimages
Evaluation of resampling-based inference for topological features of neuroimages Open
Many recent studies have demonstrated the inflated type 1 error rate of the original Gaussian random field (GRF) methods for inference of neuroimages and identified resampling (permutation and bootstrapping) methods that have better perfor…
View article: Cerebellar Effects on Abnormal Psychomotor Function Are Mediated by Processing Speed in Psychosis Spectrum
Cerebellar Effects on Abnormal Psychomotor Function Are Mediated by Processing Speed in Psychosis Spectrum Open
View article: Hippocampal Network Dysfunction in Early Psychosis: A 2-Year Longitudinal Study
Hippocampal Network Dysfunction in Early Psychosis: A 2-Year Longitudinal Study Open
These results show abnormally elevated functional connectivity in a core hippocampal-MTLC network in early psychosis, suggesting that selectively increased hippocampal signaling within a localized cortical circuit may be a marker of the ea…
View article: Cerebellar Structure and Cognitive Ability in Psychosis
Cerebellar Structure and Cognitive Ability in Psychosis Open
View article: Incomplete Hippocampal Inversion: A Neurodevelopmental Mechanism for Hippocampal Shape Deformation in Schizophrenia
Incomplete Hippocampal Inversion: A Neurodevelopmental Mechanism for Hippocampal Shape Deformation in Schizophrenia Open
View article: Increased amplitude of hippocampal low frequency fluctuations in early psychosis: A two-year follow-up study
Increased amplitude of hippocampal low frequency fluctuations in early psychosis: A two-year follow-up study Open
View article: Development of Thalamocortical Structural Connectivity in Typically Developing and Psychosis Spectrum Youths
Development of Thalamocortical Structural Connectivity in Typically Developing and Psychosis Spectrum Youths Open
View article: Attention-deficit/hyperactivity disorder in youth with psychosis spectrum symptoms
Attention-deficit/hyperactivity disorder in youth with psychosis spectrum symptoms Open
View article: Characterizing effects of age, sex and psychosis symptoms on thalamocortical functional connectivity in youth
Characterizing effects of age, sex and psychosis symptoms on thalamocortical functional connectivity in youth Open
View article: Lower functional connectivity of white matter during rest and working memory tasks is associated with cognitive impairments in schizophrenia
Lower functional connectivity of white matter during rest and working memory tasks is associated with cognitive impairments in schizophrenia Open
View article: BNST and amygdala connectivity are altered during threat anticipation in schizophrenia
BNST and amygdala connectivity are altered during threat anticipation in schizophrenia Open
View article: Insula sub-regions across the psychosis spectrum: morphology and clinical correlates
Insula sub-regions across the psychosis spectrum: morphology and clinical correlates Open
View article: Anterior hippocampal dysfunction in early psychosis: a 2-year follow-up study
Anterior hippocampal dysfunction in early psychosis: a 2-year follow-up study Open
Background Cross-sectional studies indicate that hippocampal function is abnormal across stages of psychosis. Neural theories of psychosis pathophysiology suggest that dysfunction worsens with illness stage. Here, we test the hypothesis th…